Search Results - clinical+and+disease+specializations+%3e+genetic+diseases+%3e+cystic+fibrosis

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Value Proposition· Autoantibody that promotes DNA degradation to diminish inflammation· Enhances endonuclease DNase1L3 activity· Avoids kidney-mediated inflammatory response Unmet Need· Extracellular DNA, also called cell-free DNA, released from dying cells or activated immune cells can be recognized by the immune system...

Published: 3/14/2025 | Inventor(s): Felipe Andrade, Jose de Jesus Eduardo Gomez-Bañuelos

Keywords(s):

Category(s): Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Gastroenterology > Inflammatory Bowel Disease, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Clinical and Disease Specializations > Inflammation > Arthritis

Redesigned Potentiometric Wearable Sweat Sensor

Unmet NeedMore than 70,000 people worldwide live with cystic fibrosis (CF) and approximately 1,000 new cases of CF arise every year. Though most people are diagnosed with CF by the age of 2, some people are diagnosed as adults. Adult diagnoses are usually difficult because they are confirmed by a sweat chloride test which is not a standard test that...

Published: 3/14/2025 | Inventor(s): Peter Searson, Dong-Hoon Choi, Garry Cutting

Keywords(s):

Category(s): Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Technology Classifications > Computers, Electronics & Software > Sensors

CF8Flp: A Cystic Fibrosis Bronchial Epithelial Cell Line with a Single Integration Site for the Stable Expression of any Gene of Interest

A Cystic Fibrosis Bronchial Epithelial Cell Line (CF8Flp)JHU REF: C12966Invention Novelty: The invention is in the form of a Cystic Fibrosis Bronchial Epithelial Cell Line with an integration site that allows for stable expression of the target protein.Value Proposition:Bronchial epithelial cells have been particularly instrumental in providing a means...

Published: 3/13/2025 | Inventor(s): Garry Cutting

Keywords(s): Basic Research Biomarker, Cell Model, Cloning Reagents, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis

Engineering Synthetic Sputum-penetrating Gene Carriers

C11417: Synthetic Sputum-penetrating Gene CarriersNovelty: The technology provides novel compositions and methods to deliver gene therapy to cystic fibrosis (CF) patients.Value Proposition: CF is one of the most common genetic disorders. Currently, there are no aerosol gene delivery methods to efficiently penetrate the hyperviscoelestic sputum in the...

Published: 3/13/2025 | Inventor(s): Jung Soo Suk, Justin Hanes

Keywords(s): Cystic Fibrosis (CF), Disease Indication, Drug Delivery Vehicle, Gene Therapy, Genetic Disorders, Nanoparticles, Polymers, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis

PS-341 Rescues Cystic Fibrosis Transmembrane Regulator (CFTR) from Endoplasmic Reticulum Mediated Degradation

UNMET NEEDThere is understanding that mutations in the cystic fibrosis transmembrane regulator (CFTR) protein can lead to life-threatening illness. When functioning normally, CFTR is thought to be a necessary cAMP-activated chloride channel. In CF, this channel is thought to be misprocessed and retained in the endoplasmic reticulum of epithelial cells,...

Published: 3/13/2025 | Inventor(s): Neeraj Vij, Pamela Zeitlin

Keywords(s): Biologics, Cystic Fibrosis, Cystic Fibrosis (CF), Disease Indication, Genetic Disorders, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities

C04772: S9, A Cystic Fibrosis bronchial epithelial cell line Technical Details: Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?508 /W1282X. IB3-1 Cells were immortalized with adeno12SV0 and later infected with a viral vector AAV carrying CFTR full length.Looking for Partners: This cell line may be useful in...

Published: 3/13/2025 | Inventor(s): William Guggino, Terence Flotte, Pamela Zeitlin

Keywords(s): Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

C38

C04744: C38 Technical Details: JHU scientists have created a Cystic Fibrosis bronchial epithelial cell line that was isolated from a patient with genotype ?508/W1282X. Cells were immortalized with adeno12SV0 and later transfected with a cDNA from AAV carrying CFTR truncated for the first 119 amino acids.Looking for Partners: This cell line may be...

Published: 3/13/2025 | Inventor(s): Pamela Zeitlin, William Guggino, Terence Flotte

Keywords(s): Adeno-Associated Virus, Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Research Reagent, Translational Research Biomarker, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Viruses, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

IB3-1

C04681: IB3-1 Technical Details: Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?F508 /W1282X. Cells were immortalized with adeno12SV0.Looking for Partners: This cell line will be useful for the identification of drugs that treat cystic fibrosis.Publications Am J Physiol Cell Physiol. 2000 Feb;278(2):C259-67Sin...

Published: 3/13/2025 | Inventor(s): William Guggino, Pamela Zeitlin

Keywords(s): Adeno Virus, Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Research Reagent, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Viruses, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools