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Short Viral RNAs (svRNAs) with Theragnostic Potential in Infection with SARS-CoV-2 and Related Viruses

Value PropositionNovel Biomarkers for Diagnosis & PrognosisInsights into viral immune evasion mechanism Identify key host pathways targeted by svRNAs Novel Therapeutic TargetsIdentified pathways enable the development of immune-modulating therapies. Unmet NeedStudies have show than SARS-CoV-2 employs various mechanisms to evade the host’s innate...

Published: 9/12/2025 | Inventor(s): Kenneth Witwer, Tom Driedonks, Andrey Turchinovich

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Infectious Diseases

Innovative Suit Designs and Doffing Methodologies for Personal Protective Equipment to prevent the spread of Ebola to Health Care Workers

Value Proposition· Increased safety: features back seam entry and exit with integrated doffing and disposal methods to reduce risk of contamination.· Easy to use: Simplified doffing decreases the complexity and time required to doff PPE.· Customizable and comfortable: Design includes sizing adjustments, sweat-wicking features, and...

Published: 9/11/2025 | Inventor(s): Youseph Yazdi, Melody Tan, Matthew Petney, William Patterson, Siavash Parkhideh, Jill Andrews, Patience Osei, Chandrakant Ruparelia, Harshadkumar Sanghvi, Timothy Harrigan, Nahyun Cho, Qian Liu, Sami Messai, Brian Ma, Meagan Hawes, Reeve Heinis, Jason Johnson, Erin Reisfeld, Arjun Vachhani, Timothy Campbell, Neil Rens, Madeleine Clegg, Elizabeth Stokley, Jessica Jeang, Christopher Chiang, Willibrord Shasha, Bailey Topper, Kimberly Ashman, Michael Parlato, Brandon Craft, Paul Fearis, Soumyadipta Acharya

Keywords(s): Disease Indication, Ebola, Industrial Manufacturing, Infectious Diseases, Manufactured Devices, Personal Protective Equipment (PPE), Safety Suits, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Ebola, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Engineering Tech > Industrial Manufacturing

A mRNA Lipid Nanoparticle Incorporated Nanofiber-hydrogel Composite to Generate a Local Immunostimulatory Niche for Immunotherapy

Value Proposition:· Creates a programmable immunostimulatory niche.· Allows for tailor-made immune responses to vaccines and antigens.· Flexible drug delivery platform enables mRNA therapeutics for infectious diseases and cancers.· Applicable to existing mRNA vaccines for improved efficacy. · Can be utilized for novel...

Published: 9/12/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Zhicheng Yao, Christine Wei

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Research Tools > Microfluidics

Self-Assembling Antiviral Prodrugs for Long-Acting Treatment of Chronic HIV Infections

Unmet Need / Invention Novelty: The need for long-acting HIV drugs arises from challenges such as pill burden, side effects, and stigma, which contribute to inconsistent use and reduced effectiveness. A long-acting antiretroviral formulation could enhance treatment adherence, reduce disease transmission, and better support populations facing barriers...

Published: 9/12/2025 | Inventor(s): Honggang Cui, Charles Flexner, Maya Monroe, Han Wang

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases > HIV, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Hepatitis B Virus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Novel Oxazolidinone Antibacterials and the Synthetic Routes to Them

Marketing Summary Draft Novel Oxazolidinone Antibacterials and the Synthetic Routes to ThemJHU Ref #: C18144Value Proposition· Higher efficacy and lower toxicity oxazolidinone compounds· Positive activity demonstrated against M. abscessus· MIC values are the same or better than the current antibiotics in the market Unmet Need The...

Published: 9/12/2025 | Inventor(s): Gyanu Lamichhane, J. Ippoliti, Cole Friederichs, Connor Winkelhake, Ben Thompson, Kelsey Latterell

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases

Novel Oxazolidinones for Treatment of Bacterial Infections

Marketing Summary DraftNovel Oxazolidinones for Treatment of Bacterial InfectionsJHU Ref #: C14633Value Proposition· Belong to the same chemical family as Zyvox, marketed by Pfizer, but shows better efficacy· Positive activity demonstrated against M. tuberculosis· MIC values the same or better than the current antibiotics in the...

Published: 9/12/2025 | Inventor(s): Gyanu Lamichhane, J. Ippoliti

Keywords(s): Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Polymers and Nanoparticles for Intramuscular Nucleic Acid Delivery

Value Proposition:· Platform technology for prophylactic and therapeutic vaccination with large RNA payloads.· Can deliver several types of nucleic acid payloads including self-amplifying mRNA, plasmid, linear DNA, siRNA, miRNA, mRNA.· Adaptable as a therapeutic delivery strategy for genetic, musculoskeletal, and neurological disorders.Unmet Need:Vaccinology...

Published: 9/12/2025 | Inventor(s): Jordan Green, David Wilson, Stephany Tzeng, Yuan Rui, Sarah Neshat, Kathryn Luly

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Infectious Diseases

Bio-engineered enzymes to replace thermal cycler machine in PCR

Unmet NeedThe COVID-19 pandemic underscored the importance of rapid and sensitive testing for infectious material to limit the spread of a virus. The gold standard of testing is detection of viral DNA by polymerase chain reaction (PCR). PCR has long been used in laboratory settings and can reliably detect viral infection at a highly sensitive level...

Published: 9/12/2025 | Inventor(s): Taekjip Ha, Momcilo Gavrilov

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Infectious Diseases

Engineered Extracellular Vehicles as a selective drug delivery platform

Value Proposition:· Engineered extracellular vesicles with enhanced uptake and reduced immunogenicity · Improved EV-based drug delivery platform Technology DescriptionResearchers at Johns Hopkins have identified endogenous proteins that can be engineered to assist in extracellular vesicle and/or nanoparticle therapeutics through increased...

Published: 9/12/2025 | Inventor(s): Kenneth Witwer, Zach Troyer

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics

Acetylated Polyamines as Biomarkers of HIV-1 Associated Neurocognitive Disorders (HAND)

Acetylated Polyamines as Biomarkers of HIV-1 Associated Neurocognitive Disorders (HAND) Marketing Summary: Polyamines are molecules, present in all organisms, whose concentrations are regulated by the enzyme Spermine/Spermidine Acetyl transferase (SSAT). SSAT works by inactivating polyamines. Once these polyamines are inactivated they are...

Published: 9/11/2025 | Inventor(s): Kamel Khalili, Carlos Barrero, Salim Merali, Jay Rappaport, Norman Haughey, Ned Sacktor

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Cognitive Impairment, Diagnostic Biomarker, Disease Indication, HIV/AIDS, HIV-Associated Neurocognitive Disorders, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology > HIV-Associated Neurocognitive Disorders

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