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Innovative Suit Designs and Doffing Methodologies for Personal Protective Equipment to prevent the spread of Ebola to Health Care Workers

Value Proposition· Increased safety: features back seam entry and exit with integrated doffing and disposal methods to reduce risk of contamination.· Easy to use: Simplified doffing decreases the complexity and time required to doff PPE.· Customizable and comfortable: Design includes sizing adjustments, sweat-wicking features, and...

Published: 3/13/2025 | Inventor(s): Youseph Yazdi, Melody Tan, Matthew Petney, William Patterson, Siavash Parkhideh, Jill Andrews, Patience Osei, Chandrakant Ruparelia, Harshadkumar Sanghvi, Timothy Harrigan, Nahyun Cho, Qian Liu, Sami Messai, Brian Ma, Meagan Hawes, Reeve Heinis, Jason Johnson, Erin Reisfeld, Arjun Vachhani, Timothy Campbell, Neil Rens, Madeleine Clegg, Elizabeth Stokley, Jessica Jeang, Christopher Chiang, Willibrord Shasha, Bailey Topper, Kimberly Ashman, Michael Parlato, Brandon Craft, Paul Fearis, Soumyadipta Acharya

Keywords(s): Disease Indication, Ebola, Industrial Manufacturing, Infectious Diseases, Manufactured Devices, Personal Protective Equipment (PPE), Safety Suits, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Ebola, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Engineering Tech > Industrial Manufacturing

A mRNA Lipid Nanoparticle Incorporated Nanofiber-hydrogel Composite to Generate a Local Immunostimulatory Niche for Immunotherapy

Value Proposition:· Creates a programmable immunostimulatory niche.· Allows for tailor-made immune responses to vaccines and antigens.· Flexible drug delivery platform enables mRNA therapeutics for infectious diseases and cancers.· Applicable to existing mRNA vaccines for improved efficacy. · Can be utilized for novel...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Zhicheng Yao, Christine Wei

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Research Tools > Microfluidics

Self-Assembling Antiviral Prodrugs for Long-Acting Treatment of Chronic HIV Infections

Unmet Need / Invention Novelty: The need for long-acting HIV drugs arises from challenges such as pill burden, side effects, and stigma, which contribute to inconsistent use and reduced effectiveness. A long-acting antiretroviral formulation could enhance treatment adherence, reduce disease transmission, and better support populations facing barriers...

Published: 3/14/2025 | Inventor(s): Honggang Cui, Charles Flexner, Maya Monroe, Han Wang

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases > HIV, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Hepatitis B Virus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Novel Oxazolidinones for Treatment of Bacterial Infections

Marketing Summary DraftNovel Oxazolidinones for Treatment of Bacterial InfectionsJHU Ref #: C14633Value Proposition· Belong to the same chemical family as Zyvox, marketed by Pfizer, but shows better efficacy· Positive activity demonstrated against M. tuberculosis· MIC values the same or better than the current antibiotics in the...

Published: 3/13/2025 | Inventor(s): Gyanu Lamichhane, J. Ippoliti

Keywords(s): Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Polymers and Nanoparticles for Intramuscular Nucleic Acid Delivery

Value Proposition:· Platform technology for prophylactic and therapeutic vaccination with large RNA payloads.· Can deliver several types of nucleic acid payloads including self-amplifying mRNA, plasmid, linear DNA, siRNA, miRNA, mRNA.· Adaptable as a therapeutic delivery strategy for genetic, musculoskeletal, and neurological disorders.Unmet Need:Vaccinology...

Published: 3/14/2025 | Inventor(s): Jordan Green, David Wilson, Stephany Tzeng, Yuan Rui, Sarah Neshat, Kathryn Luly

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Infectious Diseases

Engineered Extracellular Vehicles as a selective drug delivery platform

Value Proposition:· Engineered extracellular vesicles with enhanced uptake and reduced immunogenicity · Improved EV-based drug delivery platform Technology DescriptionResearchers at Johns Hopkins have identified endogenous proteins that can be engineered to assist in extracellular vesicle and/or nanoparticle therapeutics through increased...

Published: 3/14/2025 | Inventor(s): Kenneth Witwer, Zach Troyer

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics

Acetylated Polyamines as Biomarkers of HIV-1 Associated Neurocognitive Disorders (HAND)

Acetylated Polyamines as Biomarkers of HIV-1 Associated Neurocognitive Disorders (HAND) Marketing Summary: Polyamines are molecules, present in all organisms, whose concentrations are regulated by the enzyme Spermine/Spermidine Acetyl transferase (SSAT). SSAT works by inactivating polyamines. Once these polyamines are inactivated they are...

Published: 3/13/2025 | Inventor(s): Kamel Khalili, Carlos Barrero, Salim Merali, Jay Rappaport, Norman Haughey, Ned Sacktor

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Cognitive Impairment, Diagnostic Biomarker, Disease Indication, HIV/AIDS, HIV-Associated Neurocognitive Disorders, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology > HIV-Associated Neurocognitive Disorders

Transgenic Fungi that Kill Malaria Parasites in Mosquitoes

Invention novelty: This material is a transgenic fungus which targets the sporozoites that cause malaria in the salivary glands of mosquitoes. The fungus is taken up by direct contact with the mosquito and inhibits Plasmodium development. Value Proposition: Unmodified, Metarhizium anisopliae kills mosquitoes slowly. If mosquitoes are infected by the...

Published: 3/13/2025 | Inventor(s): Raymond St. Leger, Angray Kang, Weiguo Fang, Marcelo Jacobs-Lorena

Keywords(s): Biologics, Disease Indication, Disease Management System, Healthcare Management, Infectious Diseases, Malaria, Operations Management, Parasitic Infections, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections

Compositions and Method for Identification of HCV Vaccine Antigens Capable of Inducing Broadly Neutralizing Antibodies

Unmet Need: Currently, only a small percentage of people infected with Hepatitis C Virus (HCV) are treated with direct-acting antiviral (DAA) therapy worldwide. Whilst effective and safe, DAA remains unavailable to many, especially in resource limited settings, and curative treatment does not prevent continued disease progression or reinfection. To...

Published: 3/14/2025 | Inventor(s): Justin Bailey, Nicole Frumento, Andrea Lynn Cox

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases

Antiviral Azide Containing Compounds

Unmet Need: Viral infections in humans, animals, plants and insects lead to many societal burdens including disease and agricultural loss. Most anti-viral treatment strategies to date are limited in scope to the virus of interest and often result in drug resistance, incomplete efficacy, and/or toxicity. Costs for viral specific targets can be massive...

Published: 3/13/2025 | Inventor(s): Upinder Singh, Scott Grecian, Brian Agnew, David Graham

Keywords(s): Antagonists/Inhibitors, Disease Indication, Drug Delivery Mechanism, Infectious Diseases, Oral Administration, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

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