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CF8Flp: A Cystic Fibrosis Bronchial Epithelial Cell Line with a Single Integration Site for the Stable Expression of any Gene of Interest

A Cystic Fibrosis Bronchial Epithelial Cell Line (CF8Flp)JHU REF: C12966Invention Novelty: The invention is in the form of a Cystic Fibrosis Bronchial Epithelial Cell Line with an integration site that allows for stable expression of the target protein.Value Proposition:Bronchial epithelial cells have been particularly instrumental in providing a means...

Published: 3/13/2025 | Inventor(s): Garry Cutting

Keywords(s): Basic Research Biomarker, Cell Model, Cloning Reagents, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis

Engineering Synthetic Sputum-penetrating Gene Carriers

C11417: Synthetic Sputum-penetrating Gene CarriersNovelty: The technology provides novel compositions and methods to deliver gene therapy to cystic fibrosis (CF) patients.Value Proposition: CF is one of the most common genetic disorders. Currently, there are no aerosol gene delivery methods to efficiently penetrate the hyperviscoelestic sputum in the...

Published: 3/13/2025 | Inventor(s): Jung Soo Suk, Justin Hanes

Keywords(s): Cystic Fibrosis (CF), Disease Indication, Drug Delivery Vehicle, Gene Therapy, Genetic Disorders, Nanoparticles, Polymers, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis

PS-341 Rescues Cystic Fibrosis Transmembrane Regulator (CFTR) from Endoplasmic Reticulum Mediated Degradation

UNMET NEEDThere is understanding that mutations in the cystic fibrosis transmembrane regulator (CFTR) protein can lead to life-threatening illness. When functioning normally, CFTR is thought to be a necessary cAMP-activated chloride channel. In CF, this channel is thought to be misprocessed and retained in the endoplasmic reticulum of epithelial cells,...

Published: 3/13/2025 | Inventor(s): Neeraj Vij, Pamela Zeitlin

Keywords(s): Biologics, Cystic Fibrosis, Cystic Fibrosis (CF), Disease Indication, Genetic Disorders, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities

C04772: S9, A Cystic Fibrosis bronchial epithelial cell line Technical Details: Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?508 /W1282X. IB3-1 Cells were immortalized with adeno12SV0 and later infected with a viral vector AAV carrying CFTR full length.Looking for Partners: This cell line may be useful in...

Published: 3/13/2025 | Inventor(s): William Guggino, Terence Flotte, Pamela Zeitlin

Keywords(s): Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

C38

C04744: C38 Technical Details: JHU scientists have created a Cystic Fibrosis bronchial epithelial cell line that was isolated from a patient with genotype ?508/W1282X. Cells were immortalized with adeno12SV0 and later transfected with a cDNA from AAV carrying CFTR truncated for the first 119 amino acids.Looking for Partners: This cell line may be...

Published: 3/13/2025 | Inventor(s): Pamela Zeitlin, William Guggino, Terence Flotte

Keywords(s): Adeno-Associated Virus, Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Research Reagent, Translational Research Biomarker, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Viruses, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

IB3-1

C04681: IB3-1 Technical Details: Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?F508 /W1282X. Cells were immortalized with adeno12SV0.Looking for Partners: This cell line will be useful for the identification of drugs that treat cystic fibrosis.Publications Am J Physiol Cell Physiol. 2000 Feb;278(2):C259-67Sin...

Published: 3/13/2025 | Inventor(s): William Guggino, Pamela Zeitlin

Keywords(s): Adeno Virus, Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Research Reagent, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Viruses, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools