Search Results - kevin+see

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Hexosamine Analogs for Regenerative Medicine and Diseases Associated with the Musculoskeletal System

Unmet Need:Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 32.5 million adults in the United States, with an increasing incidence as the population ages (see CDC) . OA is associated with considerable morbidity as a consequence of joint damage, resulting in pain, loss of joint range of motion, and disability. The disease...

Published: 6/27/2024 | Inventor(s): Kevin Yarema, Jennifer Elisseeff, Jeannine Coburn, Udayanath Aich

Keywords(s): Antagonists/Inhibitors, Arthritis, Biologics, Carbohydrates, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Joint Disorders, Novel, Osteoarthritis, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Rheumatology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Rheumatology > Arthritis, Clinical and Disease Specializations > Rheumatology > Osteoarthritis

AI Based Disease Prognosis of Patients with Parkinson's Disease

Unmet NeedParkinson’s Disease affects over 6 million people globally, and is one of the fastest growing neurodegenerative diseases in prevalence, disability, and deaths (GBD 2016 Parkinson’s Disease Collaborators). Presently, Parkinson’s diagnosis and prognosis depend on monitoring a patient’s symptoms and occasional imaging of the affected region of...

Published: 6/28/2024 | Inventor(s): Yong Du, Kevin Leung, Martin Pomper

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Clinical and Disease Specializations > Neurology > Parkinson’s Disease, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Diagnostics

AI-based Disease Detection from Raw SPECT and PET Data without Image Reconstruction

Inventor(s): Yong Du, Kevin Leung, Martin Pomper, Steven RoweUnmet NeedParkinson’s disease (PD) is the second most common neurodegenerative disorder, with approximately 60,000 Americans diagnosed with it each year. It is a progressive nervous system disorder that affects movement, from small tremors to a loss of automatic movements. One of the tools...

Published: 6/28/2024 | Inventor(s): Yong Du, Kevin Leung, Martin Pomper, Steven Rowe

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Clinical and Disease Specializations > Neurology > Parkinson’s Disease, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Diagnostics

AI Based Medical Image Generation

Unmet NeedAdvances in medical imaging has radically changed the practice of medicine in the last few decades. Recently, machine learning techniques have been shown to produce higher fidelity images in various modalities and to aid in diagnostics (Lundervold & Lundervold, 2019). Machine learning imaging research require large datasets to be trained...

Published: 6/28/2024 | Inventor(s): Yong Du, Kevin Leung, Martin Pomper, Steven Rowe, Wenyi Shao

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Medical Devices > Imaging

B7-DC Knockout Mice

Detailed DescriptionThe Pdcd1lg2 gene encodes the costimulatory molecule PD-L2 which is expressed in dendritic cells (DCs). To establish the mouse line Stk 017515 - B6N.129(Cg)-Pdcd1lg2tm2Dmp/J which is deficient for PD-L2, a genomic fragment containing exon 2 of the programmed cell death 1 ligand 2 (Pdcd1lg2 which encodes PD-L2) gene, two of loxP sites...

Published: 6/27/2024 | Inventor(s): Drew Pardoll, Lieping Chen, Kevin Gorski, Haruo Tsuchiya, Tahiro Shin

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models

A Platform to Improve Metabolic Glycoengineering in Biomanufacturing

Unmet Need: Methods to control glycosylation, a critical post-translational modification of therapeutic proteins, now focus on maintaining conventional glycosylation profiles. Strict adherence to naturally-occurring glycosylation patterns, however, hinders and in some cases precludes the development of novel protein therapeutics required for rare diseases...

Published: 6/28/2024 | Inventor(s): Kevin Yarema, Christian Agatemor, Christopher Saeui, Matthew Buettner, Jamie Spangler, Seth Ludwig, Zachary Bernstein, Kris Dammen-Brower, Riddhima Deenar Chitre

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Industrial Tech

Neuroinspired Algorithms for Swarming Applications

Unmet NeedSwarm Intelligence is a relatively new branch of Artificial Intelligence that models the collective behavior of social swarms in groups of animals (ants, bees, birds). Swarming applications are agent-based algorithms that are capable of developing robust, self-organized solutions to emerging critical needs in modern day society. A major challenge...

Published: 6/27/2024 | Inventor(s): Joseph Monaco, Kechen Zhang, Grace Hwang, Kevin Schultz, Robert Chalmers

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Drones

CortiTech

Unmet NeedDeep-seated brain tumors are exceedingly difficult to treat surgically and careful treatment planning is required in order to avoid unintended brain damage during surgery. Currently, about 9% of patients undergoing neurosurgical operations experience surgical complications related to the retractor (a paddle-like tool used to open a working...

Published: 6/28/2024 | Inventor(s): Alan Cohen, Kevin Tu, Rohith Bhethanabotla, Jody Mou, Sun Jay Yoo, Rajiv Iyer, Daniel Rosenthal Garber, Callie Deng, Linh Tran, Jack Ye, Wataru Ishida, Mark Shifman, Ananyaa Sivakumar, Rene DeBrabander, Reena Elizebath

Keywords(s): Balloons, CNS and Neurological Disorders, Dilators/Retractors, Disease Indication, Interventional and Surgical Systems, Surgical Instruments

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Surgical

A Method for Image to World Registration for Medical Augmented Reality Applications Using a World Spatial Map

Unmet NeedDue to the 2 dimensional nature of fluoroscopic imaging, when performing surgery aided by X-rays, surgeons are required to undergo serious mental gymnastics to situate themselves and their tools in flat images. Historically, doctors have used visual markers such as wires or drawn lines to aid in depth perception and place themselves accurately...

Published: 6/27/2024 | Inventor(s): Alex Johnson, Kevin Yu, Sebastian Andress, javad Fotouhi, Greg Osgood, Nassir Navab, Mathias Unberath

Keywords(s): Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, In Vivo Medical Imaging

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging

3D Woven Lattices as Multi-functional Heat Exchanger

Unmet NeedPorous materials are a widely used heat exchanger for common household items such as radiators and refrigerators. However, these materials are typically focused on optimizing at most one or two physical/chemical properties (heat transfer, fluidic permeability, electrical conductivity, etc.). As a result, these materials tend to underperform...

Published: 6/27/2024 | Inventor(s): Kevin Hemker, Timothy Weihs, Stephen Ryan, Longyu Zhao, Seunghyun Ha, Yong Zhang, Sen Lin, James Guest, Keith Sharp

Keywords(s): Heat Exchangers, HVAC Systems, Industrial Manufacturing, Manufactured Devices, Manufacturing Method, Weaving

Category(s): Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Industrial Manufacturing

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