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A Workflow for Multiplex Protein Imaging with Co-detection of Low Abundant Molecules and Proteins

Value PropositionMultiplex Capability: Enables iterative TSA applications, a capability previously unattainable in highly multiplexed platforms which are currently capable of only eight markers per section.High Sensitivity: Detects lowly-abundant proteins to map the full complexity of tissues architecture without degrading tissue morphology or antigenicity...

Published: 9/12/2025 | Inventor(s): Pei-Hsun Wu, Fan Wu, Denis Wirtz

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Imaging

Enhanced Fluorescence Signal through the Application of Aromatic Additives onto the Microscopy Sample for Standard Fluorescence, Fluorescence Microscopy, and Combined Fluorescence MALDI Microscopy/imaging

Value Proposition· Enhanced Fluorescence Intensity: Increases signal strength, enabling detection of molecules that are undetectable with traditional fluorescence microscopy and imaging techniques· Improved Efficiency: Requires less dye to achieve strong fluorescence signals and protects the sample from oxidative degradation, reducing reagent...

Published: 9/12/2025 | Inventor(s): Kristine Glunde, Ethan Yang, Caitlin Tressler, Scot Kuo, Hoku Kahele West-Foyle, Xinyi Shen

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Medical Devices > Imaging

Methods for in situ Detection of DNA Sequence Variation

Value Proposition· High-throughput· Assess genetic variants with simultaneous spatial analysis· Interrogate over 100 variants in a single assayUnmet Need· Next generation sequencing has led to an ever-proliferating dearth of genetic information. More recent progress in nucleoside tissue analysis has birthed the field of spatial...

Published: 9/12/2025 | Inventor(s): Reza Kalhor, Soichiro Asami

Keywords(s):

Category(s): Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids

Spatial Photo-Patterning of Nematic Liquid Crystal Pre-Tilt and its Application in Fabricating Flat Gradient-Index Lenses

Value Proposition:· Enhanced tunability and spatial patterning ability for both polar and azimuthal orientations· Efficient and less error-prone liquid crystal patterning processes· Versatility in pretilt angles for a variety of applications· Stable liquid crystal configurations that reduce the need for external voltages and...

Published: 9/12/2025 | Inventor(s): Robert Leheny, Alvin Modin, Francesca Serra

Keywords(s):

Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools

Imaging Mannose Overexpression for Grading Glioblastoma Aggressiveness

Value Proposition:Label-free MRI method that requires no regulatory approval or additional drug developmentCan significantly decrease the time between initial diagnosis and follow-up treatment, as tumor aggressiveness could be predicted during the initial diagnostic MRI, improving patient survival rates and post-treatment evaluationNon-invasive diagnostic...

Published: 9/12/2025 | Inventor(s): Jeff Bulte, Behnaz Ghaemi

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Glioblastoma, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Research Tools > Imaging

18F-Labeled PET Radiotracers for Imaging Neuroinflammation in the Brain

Value Proposition:· Quantification and PET imaging of microglial cells in the brain· Diagnostic for neuroinflammatory disorders – Alzheimer’s and MS· Favorable compound half-life enables shipping· Potential for non-CNS applications Technology DescriptionResearchers at Johns Hopkins have developed a series of Positron Emission Tomography...

Published: 9/12/2025 | Inventor(s): Martin Pomper, Deepankar Das, Andrew Horti, Wojciech Lesniak

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

Intracellular actuator that generates and manipulates physical force in living cells

Marketing Summary DraftIntracellular actuator that generates and manipulates physical force in living cellsJHU Ref #: C14896Value PropositionPhysical force generation inside living cells via light irradiation and chemical treatmentThis research tool can be applied to arbitrary intracellular targets in a specific and spatiotemporal mannerSystem is built...

Published: 9/12/2025 | Inventor(s): Takanari Inoue, Hideki Nakamura, Elmer Rho

Keywords(s): Discovery/Research Tools, Peptides, Recombinant Proteins, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Vectors & Plasmids

High Throughput Single Cell Resolution Analysis Software

Unmet NeedBiological research relies on accurate and precise image analysis, from tracking cells over time, assessing changes to organelles under experimental conditions, to quantifying localization of immunofluorescence. As imaging technology advances and biological questions become more detailed, a massive amount of high-resolution data is acquired...

Published: 9/12/2025 | Inventor(s): Gordon Sun

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Research Tools > Imaging

Myelin Protein Zero (MPZ)-targeting Compounds and Uses Thereof

Unmet NeedPeripheral nerve injuries require optimally timed intervention to maximize functional recovery and minimize permanent nerve death and negative impacts to quality of life. Current treatment plans rely primarily on monitoring for spontaneous healing or an indication that there must be surgical intervention, an approach that hinges on accurate...

Published: 9/12/2025 | Inventor(s): Martin Pomper, Catherine Foss, Sami Tuffaha, William Padovano, Bei Cheng

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

Using CD29 as a Marker for Cell Identification in Single Cell Analysis

AbstractWith the advent of cancer immunology, mass cytometry has been increasingly employed to characterize the responses to cancer therapies and the tumor microenvironment (TME). One of its most notable applications is efficient multiplexing of samples into batches by dedicating a number of metal isotope channels to barcodes, enabling robust data acquisition...

Published: 9/12/2025 | Inventor(s): Won Jin Ho, Elizabeth Jaffee, Soren Charmsaz, Nicole Gross

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Research Antibodies, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Imaging

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