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A Machine Learning Framework for Tagged MRI Analysis

Value Proposition: The BRITE framework operates on tagged MRI data to significantly improve the accuracy and efficiency of evaluating motion and strain in tissues. This advancement enables clinicians to make more informed decisions regarding patient care, particularly in diagnosing cardiovascular conditions and analyzing brain mechanics, ultimately...

Published: 3/13/2026 | Inventor(s): Zhangxing Bian, Jerry Prince, Shuwen Wei, Ahmed Alshareef, Jiachen Zhuo

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

Spatial Analysis of RNA Using Probe Ligation and Amplification in situ

Unmet NeedTraditional gene expression methods that use bulk RNA analysis lack the ability to resolve transcript location, and thus fail to capture the inherent cellular heterogeneity present in virtually every tissue. Abundance and localization of RNA transcripts mapped to specific regions of tissue can complement histological analysis, providing an...

Published: 3/13/2026 | Inventor(s): Harry Larman, Joel Credle

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

MS-cleavable Photo-crosslinkers for Proteome-wide Photo-crosslinking Mass Spectrometry

Reagents for Crosslinking Mass SpectrometryJHU Ref #: C17605 Value Proposition:• MS-cleavable crosslinkers for capturing protein-protein interactions. • Compounds feature an NHS group and diazirine for covalent non-specific residue linkages.• Avoid the N2 problem. • Compounds are water-soluble and cell-permeable. Technology DescriptionResearchers at...

Published: 3/13/2026 | Inventor(s): Piyoosh Sharma, Stephen Fried, Anneliese Faustino

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Peptides

High-Throughput Machine Vision and Deep-Learning Analysis Method for Cell Migration Tracking

Value Proposition· High Throughput Research Assay: perform experiments on the order of hours, compared to the order of months with existing methods.· Adaptable Algorithm: method evolves as cell motility understanding expands, preventing obsolescence through new discoveries. · Accessible and Integrable: label-free tracking using...

Published: 3/13/2026 | Inventor(s): Pei-hsun Wu, Denis Wirtz

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Assays, Technology Classifications > Computers, Electronics & Software > Machine Learning

A Workflow for Multiplex Protein Imaging with Co-detection of Low Abundant Molecules and Proteins

Value PropositionMultiplex Capability: Enables iterative TSA applications, a capability previously unattainable in highly multiplexed platforms which are currently capable of only eight markers per section.High Sensitivity: Detects lowly-abundant proteins to map the full complexity of tissues architecture without degrading tissue morphology or antigenicity...

Published: 3/13/2026 | Inventor(s): Pei-hsun Wu, Fan Wu, Denis Wirtz

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Imaging

Enhanced Fluorescence Signal through the Application of Aromatic Additives onto the Microscopy Sample for Standard Fluorescence, Fluorescence Microscopy, and Combined Fluorescence MALDI Microscopy/imaging

Value Proposition· Enhanced Fluorescence Intensity: Increases signal strength, enabling detection of molecules that are undetectable with traditional fluorescence microscopy and imaging techniques· Improved Efficiency: Requires less dye to achieve strong fluorescence signals and protects the sample from oxidative degradation, reducing reagent...

Published: 3/13/2026 | Inventor(s): Kristine Glunde, Ethan Yang, Caitlin Tressler, Scot Kuo, Hoku Kahele West-Foyle, Xinyi Shen

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Medical Devices > Imaging

Methods for in situ Detection of DNA Sequence Variation

Value Proposition· High-throughput· Assess genetic variants with simultaneous spatial analysis· Interrogate over 100 variants in a single assayUnmet Need· Next generation sequencing has led to an ever-proliferating dearth of genetic information. More recent progress in nucleoside tissue analysis has birthed the field of spatial...

Published: 3/13/2026 | Inventor(s): Reza Kalhor, Soichiro Asami

Keywords(s):

Category(s): Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids

Spatial Photo-Patterning of Nematic Liquid Crystal Pre-Tilt and its Application in Fabricating Flat Gradient-Index Lenses

Value Proposition:· Enhanced tunability and spatial patterning ability for both polar and azimuthal orientations· Efficient and less error-prone liquid crystal patterning processes· Versatility in pretilt angles for a variety of applications· Stable liquid crystal configurations that reduce the need for external voltages and...

Published: 3/13/2026 | Inventor(s): Robert Leheny, Alvin Modin, Francesca Serra

Keywords(s):

Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools

Imaging Mannose Overexpression for Grading Glioblastoma Aggressiveness

Value Proposition:Label-free MRI method that requires no regulatory approval or additional drug developmentCan significantly decrease the time between initial diagnosis and follow-up treatment, as tumor aggressiveness could be predicted during the initial diagnostic MRI, improving patient survival rates and post-treatment evaluationNon-invasive diagnostic...

Published: 3/13/2026 | Inventor(s): Jeff Bulte, Behnaz Ghaemi

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Glioblastoma, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Research Tools > Imaging

18F-Labeled PET Radiotracers for Imaging Neuroinflammation in the Brain

Value Proposition:· Quantification and PET imaging of microglial cells in the brain· Diagnostic for neuroinflammatory disorders – Alzheimer’s and MS· Favorable compound half-life enables shipping· Potential for non-CNS applications Technology DescriptionResearchers at Johns Hopkins have developed a series of Positron Emission Tomography...

Published: 3/13/2026 | Inventor(s): Martin Pomper, Deepankar Das, Andrew Horti, Wojciech Lesniak

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

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