Search Results - chia-ying+liu

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Polymers for Binding-Triggered Antibody Precipitation and Purification

Value PropositionResults in >97% precipitation yield, >88% elution yield of mAbsSimplified molecular design compared to elastin-like polypeptide (ELP)-based materialsDoes not need additional salt to achieve mAb precipitation and recoveryTechnology DescriptionResearchers at Johns Hopkins have developed a peptide-based platform technology using...

Published: 6/28/2024 | Inventor(s): Honggang Cui, Yi Li, David Stern, XuanKuo Xu, Lye Lin Lock, Jason Mills, Sanchayita Ghose, Zheng Jian Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

A Novel Supramolecular High Affinity Protein-Binding System for Purification of Biomacromolecules

Market hold: no patent application filed for this invention.Unmet Need· It is estimated that between ~50-80% of costs in antibody production are spent in purification (Mustafaoglu et al. 2016), which is typically performed by affinity chromatography. Although this method has adequate binding affinity and selectivity, the process remains costly...

Published: 6/27/2024 | Inventor(s): Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li

Keywords(s): Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics > Biomarkers

Novel universal stem cell-based therapy for the treatment of retinal diseases

Unmet Need / Invention Novelty: Gene augmentation therapy, the current technology for treatment of inherited retinal diseases, is limited by its 1) small cargo capacity which challenges the delivery of larger genes 2) ability to target only a single genetic mutation, and thus disease subtype, at a time, and 3) applicability only to recessive diseases...

Published: 6/28/2024 | Inventor(s): Mandeep Singh, Seth Blackshaw, Robert Johnston, Jiang Qian, Ying Liu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies

Growth and Site-specific Organization of Micro-scale Bimolecular Devices on Living Mammalian Cells

Unmet Need: One aspect of a cell’s function is its ability to form organized structures both within the cell and with its immediate surrounding environment. On cell surfaces, these nanostructures can serve as scaffolds or operate functionally to aid in cellular fate decisions, signal amplification and cellular cross-talk. There is a need to understand...

Published: 6/28/2024 | Inventor(s): Rebecca Schulman, Sisi Jia, Siew Cheng Phua, Yuta Nihongaki, Yizeng Li, Michael Pacella, Yi Li, Abdul Majeed Mohammed, Sean Sun, Takanari Inoue

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Approaches to Engineering Self-Assembling Peptide Filaments for Protein Binding and Purification

Unmet NeedPeptide amphiphiles (PA) are engineered biomaterials that can self-assemble into nanostructures with specific functions, such as binding to biomarkers for a variety of diseases, binding to specific proteins for purification purposes, or for binding to location specific regions for locally administering drugs. Most PAs currently synthesized...

Published: 6/27/2024 | Inventor(s): Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Reagent

Category(s): Technology Classifications > Research Tools

Strain Relaxation Index of Left Ventricular Diastolic Function

C12046: Indicator of Overall Heart HealthNovelty: This invention helps quantify overall heart health by assigning an index to left ventricle performance.Value Proposition: Current predictors and diagnostics of heart failure and future heart health include such metrics as blood pressure and low-density/high-density lipoprotein (LDL/HDL) concentration....

Published: 6/27/2024 | Inventor(s): Joao A. C. Lima, Boaz Rosen, Chia-Ying Liu, Anderson Armstrong, Bharath Ambale Venkatesh

Keywords(s): Cardiac Arrest, Cardiovascular Diseases, Disease Indication, Image Display Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Cardiac Arrest, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Imaging, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices

Enhancement of Adenoviral Oncolytic Activity by Modification of the E1A Gene Product

Unmet Need: Prostate cancer is a multi-focal disease with clones of androgen-sensitive and androgen-refractory cells, yet, the specific role androgen receptors (ARs) may play in prostate cancer in not clear. There remains an unmet need for new specific treatment modalities that selectively target diseased tissue and are capable of effectively killing...

Published: 6/27/2024 | Inventor(s): Ying Li, Ronald Rodriguez

Keywords(s): Cancers, Disease Indication, Prostate Cancer, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology