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The Role of IL17 in Age-related Immune-stromal Network Inhibiting Response to Regenerative Immunotherapy

Combination immunotherapy to enhance tissue regeneration in the elderly JHU Ref #: [C17006] Value Proposition· Regenerative medicine strategies aim to restore or replace damaged tissues and organs, with patients suffering from chronic diseases, injuries, and degenerative conditions as the end-users of regenerative medicine therapies.· Current...

Published: 1/22/2026 | Inventor(s): Jennifer Elisseeff, Jin Han, Christopher Cherry, Drew Pardoll

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Traumatic Injury, Clinical and Disease Specializations > Wound Healing

Method of enhancing anti-inflammatory properties of extracellular vesicles

Value Proposition· Promotes adenosine production to inhibit proinflammatory cytokine release· Promotes regulatory T cells expansion· Suppresses effector immune responses· Amplifies a natural, local anti-inflammatory signal, which lowers risk of unintended side effects· Targets specific inflammatory microenvironments to minimize...

Published: 1/22/2026 | Inventor(s): Kenneth Witwer, Matias Ostrowski, Paula Soledad Perez, Tomas Grosso, Martina Fabiano

Keywords(s):

Category(s): Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Inflammation > Chronic Inflammatory Diseases

Gas6-functionalized extracellular vesicles for treatment of inflammatory conditions

Value Proposition· Superior Anti-Inflammatory Potency: This membrane-associated GAS6 demonstrates over 10-fold higher anti-inflammatory activity compared to equivalent amounts of soluble recombinant GAS6 proteins. · Dual Mechanism of Action: Inhibits pro-inflammatory cytokine production and concurrently stimulates anti-inflammatory responses,...

Published: 1/22/2026 | Inventor(s): Kenneth Witwer, Matias Ostrowski, Martina Fabiano, Alan Adamczyk

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Predictive Algorithms for MISKD Clinical Decision Support System

Unmet NeedChildren hospitalized with SARS-Cov-2 infection are at risk for two similar inflammatory syndromes: Kawasaki disease (KD), and multi-system inflammatory syndrome in children (MIS-C). However, current clinical diagnostic standards for these two conditions have considerable overlap, which can lead to misdiagnosis and suboptimal treatment and...

Published: 1/22/2026 | Inventor(s): Cedric Manlhiot, Bhargava Kumar Chinni, Shelby Kutty

Keywords(s):

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Clinical and Disease Specializations > Infectious Diseases > Covid-19, Clinical and Disease Specializations > Inflammation

Monoclonal Antibody to Treat Autoinflammation Associated with Chronic Diseases

Unmet NeedAutoinflammatory responses, your body’s innate defense mechanism against infections and stressors, can become overactive and cause chronic inflammation in various tissues and organs. Inflammatory diseases affect more than 200 million people worldwide and include pulmonary hypertension, scleroderma, rheumatoid arthritis, pulmonary fibrosis,...

Published: 1/22/2026 | Inventor(s): Roger Johns

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Novel Therapeutic Drug for Multiple Sclerosis

INVENTION NOVELTY This molecule, through its action on a unique target that is different from current therapeutic treatments for MS, has both immunosuppressive and neuromodulatory properties that will better prevent the progression of MS and repair the neuronal damage caused by the immune cells in MS. Currently, there are no MS drugs in the market...

Published: 1/22/2026 | Inventor(s): Paul Kim, Michael Kornberg, Peter Calabresi, Solomon Snyder

Keywords(s): Chronic Inflammatory Diseases, CNS and Neurological Disorders, Disease Indication, Multiple Sclerosis, Multiple Sclerosis (MS), Neurodegeneration, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Discovery of Novel Aryl Hydrocarbon Receptor Ligands and their Analogues for the Prevention and Treatment of Inflammatory Disorders

Unmet Need: Necrotizing enterocolitis (NEC) is the acute onset of inflammation in the gut of babies, and is the leading cause of premature infant mortality from gastrointestinal disease. The mortality of NEC is over 30%, and those infants who do survive suffer significant deficiency due to the effects of a damaged intestine, as well as profound cognitive...

Published: 1/22/2026 | Inventor(s): David Hackam, Peng Lu, Chhinder Sodhi, Peter Wipf, David Kornfilt

Keywords(s):

Category(s): Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Inflammation > Necrotizing Enterocolitis, Technology Classifications > Therapeutic Modalities

Screening Method to Identify Scleroderma Immune Responses with Anti-cancer Activity, and Induction of such Immune Responses for Cancer Therapy

Unmet NeedEpidemiological studies have shown that patients with scleroderma, a type of autoimmune rheumatic disease affecting the skin and connective tissues, have an increased risk of developing cancer relative to the general population. The exact etiology of scleroderma is still unknown. The Scleroderma Foundation estimates about 100,000 to 300,000...

Published: 1/22/2026 | Inventor(s): Ami Shah, Livia Casciola-Rosen, Antony Rosen, Takeru Igusa, Marikki Laiho

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Risk Stratification, Scleroderma, Skin Disorders, Skin Fibrosis, Therapeutic Matter, Therapeutic Substance, Therapeutics

Endoscopic Accessory for Indocyanine Green (ICG)-Based Biliary Imaging during ERCP

Unmet NeedThe Endoscopic Retrograde Cholangiopancreatography (ERCP) procedure is used to perform therapies such as retrieving obstructing gallstones, expanding tissue strictures, or placing a stent to relieve obstruction from malignancies. The procedure requires precision and a high degree of technical skill. For physicians to perform the procedure...

Published: 1/22/2026 | Inventor(s): Marc Chelala, Sritam Rout, Maria Torres, Kyle Cowdrick, Amir Soltanianzadeh, David Gullotti, Pankaj Pasricha, Nicholas Durr

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Pancreatic Disorders, Pancreatitis

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Medical Devices > Imaging, Clinical and Disease Specializations > Inflammation, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Inflammation > Pancreatitis

Human immunoglobulin purified from NMO-IgG positive patient plasma

Purified Human IgG Antibodies from Positive NMO- IgG PatientJHU REF: [C12575]Invention Novelty: This technology provides purified human IgG antibodies isolated from plasma cells from a Neuromyelitis Optica (NMO) positive patient. Value Proposition: NMO or Devic’s disease is a rare inflammatory disease in the optic nerves, and spinal cord where specific...

Published: 1/22/2026 | Inventor(s): Michael Levy

Keywords(s): Antibodies, Blood Samples, Buffer/Media Solution, Chronic Inflammatory Diseases, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Neurodegeneration, Neuromyelitis Optica, Neuromyelitis optica (NMO), Optic Neuritis, Polyclonal Antibodies, Research Reagent, Translational Research Biomarker

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