Search Results - proteomics%2fimmunoassays

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Unmet NeedMonoclonal Antibodies (mAB) serve an important role in cellular research and therapeutic applications. They are utilized to better understand various systems such as biochemical pathways, diseases, and mutations in the structures of invertebrates. There is a need to develop antibodies that specifically target areas within the biological landscape...

Published: 3/13/2025 | Inventor(s): Michael Matunis

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools

A Novel mAb20-based In-cell ZnT8 Assay

Unmet Need: Prevalence of Type 2 Diabetes (T2D) continues to rapidly increase worldwide, contributing significant economic and global health burdens. There is an urgent need for the development of novel therapeutic strategies to treat T2D.Technical Details: Johns Hopkins researchers have identified a novel target to treat T2D and report here the development...

Published: 3/14/2025 | Inventor(s): Dax Fu, Chengfeng Merriman

Keywords(s): Analytical Method, Diabetes, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Metabolic Disorders, Proteomics/Immunoassays, Research Reagent, Target-based Screening Tool, Type II Diabetes

Category(s): Clinical and Disease Specializations > Diabetes > Type 2 Diabetes, Technology Classifications > Research Tools > Assays, Technology Classifications > Therapeutic Modalities > Targets

Production, Purification, Reconstitution and Functional Characterization of a Human Zinc Transporter ZnT8

Unmet NeedThe escalating type-2 diabetes (T2D) epidemic is a major global health concern. Genes affecting risk for T2D include the zinc transporter gene ZnT8. There exist a need for better production, purification, reconstitution and functional characterization of the human ZnT8, and improved methods for detection and treatment of T2D.Technology OverviewThe...

Published: 3/13/2025 | Inventor(s): Dax Fu

Keywords(s): Discovery/Research Tools, Proteomics/Immunoassays, Research Reagent

Category(s): Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

The CS Tag: A More Sensitive and Specific Protein Tag

Protein tags are short linear sequences that are added onto proteins in order to facilitate their detection. The most commonly used tags are FLAG, Myc, HA and His ). Tagging proteins has two primary uses. The first is for protein expression in heterologous systemsand the second use is in localization studies. . We and others have found that antibodies...

Published: 3/13/2025 | Inventor(s): Photini Sinnis, Fidel Zavala

Keywords(s): Discovery/Research Tools, Labels/Markers, Proteomics/Immunoassays, Research Reagent

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics

A Rabbit Polyclonal Antibodies Specific for S113 and S117 Phosphorylated Sam68 (Src-associated substrate in mitosis of 68 kDa), an RNA-binding Protein with Multi-functions in the Cell

Value PropositionBinds a potential novel target for pharmacological interventions, as monoclonal antibodies against CD25 are a significant treatment for C25 expressed cancers.Reports phosphorylation of S113 and S117 residues in Sam68, which is critical for the NF-kB-mediated selective transcription of the CD25 gene.Unmet NeedAnnually, there are approximately...

Published: 3/13/2025 | Inventor(s): Fengyi Wan

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools

Anti-TARP Gamma 8 pAb

Polyclonal Antibody specific for Transmembrane AMPA Receptor Protein (TARP)JHU REF: [C12231]Invention novelty: This technology is an anti-TARP [transmembrane alpha-amino-3-hydroxyl-5-isoxazolepropionate (AMPA) receptor protein] gamma 8 polyclonal antibody.Value Proposition: In many neurological diseases, AMPA receptor function and structure are altered. ...

Published: 3/13/2025 | Inventor(s): Richard Huganir

Keywords(s): Antibodies, Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Polyclonal Antibodies, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology

Rabbit Polyclonal Antibody Directed Against a Peptide Corresponding to Mouse and Human Acyl Coenzyme A Thioesterase 7 (ACOT7)

C12523: ACOT7 Antibody for Neurometabolic Profiling and Drug DiscoveryNovelty: A polyclonal antibody against ACOT7, permitting unraveling the regulation of neuronal lipid balance for the discovery of novel therapeutics for neurological diseases.Value Proposition: Dysregulated lipid metabolism has been implicated in a multitude of inborn neuropathologies...

Published: 3/13/2025 | Inventor(s): Michael Wolfgang

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Polyclonal Antibodies, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools

Mouse Anti-LAG3 Monoclonal Antibody (4-10-C9)

C11691: Mouse LAG-3 Monoclonal AntibodyNovelty: A mouse monoclonal antibody (mAb) against LAG-3 (Lymphocyte Activation Gene 3).Value Proposition: LAG-3 is expressed on the cell surface of activated T-cells and is known to be an important global regulatory molecule that controls many aspects of T-cell proliferation and homeostasis. This invention is...

Published: 3/13/2025 | Inventor(s): Dario Vignali, Charles Drake

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Monoclonal Antibodies, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools

mAb to mouse MICAL-1 and mouse MICAL-3

C11198: mAb to mouse MICAL-1 and mouse MICAL-3Value Proposition: JHU inventors have developed mouse monoclonal antibodies directed against mouse MICAL-1 and MICAL-3 proteins. These antibodies may be used in experiments involving these proteins and could also be optimized for other procedures.

Published: 3/13/2025 | Inventor(s): Qiang Wang, Rajnish Bharadwaj, Alex Kolodkin

Keywords(s): Antibodies, Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Monoclonal Antibodies, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent

Polyclonal Antisera Specific for Neuropilin-1 and Polyclonal Antisera Specific for Neuropilin-2

C10703: Polyclonal Antibodies for Neuropilin-1 (Npn-1) and Polyclonal Antibodies for Neuropilin-2 (Npn-2)Value Proposition: These are rabbit polyclonal antibodies directed against the rodent proteins neuropilin-1 and neuropilin-2. The neuropilins are semaphorin receptors.Technical Details: The semaphorin family contains a large number of phylogenetically...

Published: 3/13/2025 | Inventor(s): David Ginty, Alex Kolodkin

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Polyclonal Antibodies, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools

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