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Methods and formulations for engineered peptide conjugates for sustained intraocular drug delivery

Value Proposition· Reducing the number of daily eye drop doses required for therapeutic effect in the posterior chamber· Limited systemic absorption of medication delivered via topical eyedrops Unmet Need· The mainstay of medication delivery to the eye remains topical eye-drops. While intravitreal injections have been used to deliver...

Published: 9/12/2025 | Inventor(s): Laura Ensign, Tung Heng Hsueh, Renee Chou, Michael Cummings, Justin Hanes

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Computers, Electronics & Software > Machine Learning, Clinical and Disease Specializations > Ophthalmology

Nanofiber Nerve Cuffs to Inhibit Neuroma Formation

Nanofiber Nerve Cuff to Inhibit Neuroma FormationJHU Ref #: [C17593]Value Proposition:· This device can be used to cap the end of a severed nerve to prevent unwanted nerve growth through a combination of physical and biochemical mechanisms.· This device is more effective than existing nerve caps and cuffs, due to the inclusion of bioactive...

Published: 9/12/2025 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Ahmet Hoke, Anson Zhou, Bruce Enzmann, Michael Lan, Erica Lee, Ruifa Mi, Russell Martin

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic Devices

Mechanically-Flexible Actively-(Location)-tracked Interstitial Brachytherapy Radiation Delivery Stylet

Value PropositionUnique Flexibility and Active Tracking – currently the only stylet in existence that offers both flexibility and real-time active tracking, enhancing precision and safety in radiation delivery. Versatile Clinical Applications – suitable for various clinical uses, including radiation oncology, interventional radiology, and interventional...

Published: 9/12/2025 | Inventor(s): Ehud Schmidt, Anthony Gunderman, Yue Chen, Akila Viswanathan, Luca Neri, Ryan Baumgaertner

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices > Cardiology

SMA Urethral Continence Device

Unmet Need:Male urinary incontinence is a major problem, with limited viable solutions for patients. Current offerings require major lifestyle changes, do not work properly, or are not discrete. All of these factors severely decrease the quality of life for patients and can contribute to their frequent embarrassment from the condition. Technology OverviewResearchers...

Published: 9/12/2025 | Inventor(s): Andrew Cohen, Feng Zhu, Nathaniel Leon, Guanhao Fu

Keywords(s):

Category(s): Clinical and Disease Specializations > Urology > Urinary Incontinence, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices

A novel flexible implantable electroceutical device for recording and stimulating gastric activity

Unmet Need· Gastroparesis and functional dyspepsia (FD) are debilitating stomach disorders that together affect more than 10% of the world population. · Current approaches to treatment focus on symptom management, with pharmacological treatment being first-line; treatment efficacy is limited.· Gastric electric stimulation devices...

Published: 9/12/2025 | Inventor(s): Vivek Ganesh, Martin Stebbing, Pedro Irazoqui

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Therapeutic Devices

Nanofiber Hydrogel Composite Gel to Prevent Scarring and Adhesion of Peripheral Nerves

JHU Ref #: [C17294] Value Proposition:· Application of composite hydrogel to mechanically irritated nerves can reduce perineural adhesions and scar formation.· Improves patient outcomes following peripheral nerve surgery. Technology Description· Researchers at Johns Hopkins have developed a nanofiber-hydrogel composite (NHC) material...

Published: 9/12/2025 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Sashank Reddy, Visakha Suresh, Thomas Harris, Chenhu Qiu

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Medical Devices > Plastic Surgery, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Extracellular Vesicle‐based Agents and Methods for the Treatment of Neuropathic Disorders

Unmet Need:Human induced pluripotent stem cells (hiPSCs), and neurons differentiated from them, have been a powerful tool for modeling neuronal pathophysiologies and preclinical efficacy/toxicity screening of novel therapeutic compounds. However, these cells cultured in vitro typically do not fully recapitulate the physiology of the human nervous system,...

Published: 9/12/2025 | Inventor(s): Deok-Ho Kim, Alec Smith, Changho Chun, Minjae Do

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Cell Lines

Organ-On-A-Chip Mold with Microfluidics System

Value Proposition:3D printed mold that will allow for the rapid production of chips. Improved mold design allows microfluidics between multiple cell types.Multiple organoids enable physiologically relevant therapeutic testing.Technology DescriptionResearchers at Johns Hopkins have developed a organ on a chip model to test organ interactions, pathological...

Published: 9/12/2025 | Inventor(s): Mark Ranek, Marcus Williams, Vivek Jani, Brian Lin

Keywords(s):

Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools

Artifact Control and Miniaturization of the Safe DC Stimulator for Neural Prostheses

Safe DC Stimulator for Neural ProsthesesJHU Ref #: [C11822] Unmet NeedCurrently, neural prostheses are limited because they excite neurons but cannot efficiently inhibit them. Direct current (DC) can excite, inhibit, or control extracellular potential of target neurons, but DC stimulation is biologically unsafe. The current solution is to direct DC...

Published: 9/11/2025 | Inventor(s): Charles Della Santina, Gene Fridman

Keywords(s): CNS and Neurological Disorders, Disease Indication, Neuroprosthetic Sensing Algorithms, Neuroprosthetics, Prosthetics, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Prosthetics, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic Devices

Polymeric Nanoparticle Genetic Vaccines

Value PropositionVersatile immunotherapy platform with the ability to specifically target antigen presenting cells (APCs) ) following systemic delivery and without requiring targeting ligands to improve treatment efficacy. Flexibility to modulate the immune system through activation or inducing tolerance.Useful as a preventative strategy or therapeutic...

Published: 9/12/2025 | Inventor(s): Jordan Green, Elana Ben-Akiva, Johan Karlsson, Stephany Tzeng, Kelly Rhodes, Sarah Neshat

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

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