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Nanofiber Nerve Cuffs to Inhibit Neuroma Formation

Nanofiber Nerve Cuff to Inhibit Neuroma FormationJHU Ref #: [C17593]Value Proposition:· This device can be used to cap the end of a severed nerve to prevent unwanted nerve growth through a combination of physical and biochemical mechanisms.· This device is more effective than existing nerve caps and cuffs, due to the inclusion of bioactive...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Ahmet Hoke, Anson Zhou, Bruce Enzmann, Michael Lan, Erica Lee, Ruifa Mi, Russell Martin

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Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic Devices

A novel flexible implantable electroceutical device for recording and stimulating gastric activity

Unmet Need· Gastroparesis and functional dyspepsia (FD) are debilitating stomach disorders that together affect more than 10% of the world population. · Current approaches to treatment focus on symptom management, with pharmacological treatment being first-line; treatment efficacy is limited.· Gastric electric stimulation devices...

Published: 3/14/2025 | Inventor(s): Vivek Ganesh, Martin Stebbing, Pedro Irazoqui

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Category(s): Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Therapeutic Devices

Nanofiber Hydrogel Composite Gel to Prevent Scarring and Adhesion of Peripheral Nerves

JHU Ref #: [C17294] Value Proposition:· Application of composite hydrogel to mechanically irritated nerves can reduce perineural adhesions and scar formation.· Improves patient outcomes following peripheral nerve surgery. Technology Description· Researchers at Johns Hopkins have developed a nanofiber-hydrogel composite (NHC) material...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Sashank Reddy, Visakha Suresh, Thomas Harris, Chenhu Qiu

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Category(s): Technology Classifications, Technology Classifications > Medical Devices > Plastic Surgery, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Organ-On-A-Chip Mold with Microfluidics System

Value Proposition:3D printed mold that will allow for the rapid production of chips. Improved mold design allows microfluidics between multiple cell types.Multiple organoids enable physiologically relevant therapeutic testing.Technology DescriptionResearchers at Johns Hopkins have developed a organ on a chip model to test organ interactions, pathological...

Published: 3/14/2025 | Inventor(s): Mark Ranek, Marcus Williams, Vivek Jani, Brian Lin

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Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools

Artifact Control and Miniaturization of the Safe DC Stimulator for Neural Prostheses

Safe DC Stimulator for Neural ProsthesesJHU Ref #: [C11822] Unmet NeedCurrently, neural prostheses are limited because they excite neurons but cannot efficiently inhibit them. Direct current (DC) can excite, inhibit, or control extracellular potential of target neurons, but DC stimulation is biologically unsafe. The current solution is to direct DC...

Published: 3/13/2025 | Inventor(s): Charles Della Santina, Gene Fridman

Keywords(s): CNS and Neurological Disorders, Disease Indication, Neuroprosthetic Sensing Algorithms, Neuroprosthetics, Prosthetics, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Prosthetics, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic Devices

Polymeric Nanoparticle Genetic Vaccines

Value PropositionVersatile immunotherapy platform with the ability to specifically target antigen presenting cells (APCs) ) following systemic delivery and without requiring targeting ligands to improve treatment efficacy. Flexibility to modulate the immune system through activation or inducing tolerance.Useful as a preventative strategy or therapeutic...

Published: 3/14/2025 | Inventor(s): Jordan Green, Elana Ben-Akiva, Johan Karlsson, Stephany Tzeng, Kelly Rhodes, Sarah Neshat

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Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Johns Hopkins Stress Reduction Program

Unmet NeedWorkplace stress and its damaging knock-on effects are becoming increasingly prevalent in the United States. Approximately 40% of workers regard their job as being “very stressful” or “extremely stressful” (see American Institute for Stress). In addition to its adverse effects on mental health, long-term exposure to high levels of stress can...

Published: 3/14/2025 | Inventor(s): Neda Gould

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Category(s): Copyright, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Psychiatry > Anxiety

Closed-loop Peripheral Nerve Stimulation for Restoration in Chronic Pain

Unmet NeedChronic pain affects about 100-million adults in the United States and is primarily treated with drugs, which can have significant negative side effects (NIH-Institute of Medicine). A promising alternative therapy is electrical peripheral nerve stimulation (PNS) therapy. However, PNS therapy has been associated with suboptimal efficacy because...

Published: 3/14/2025 | Inventor(s): Sridevi Sarma, Christine Beauchene, Yun Guan, Claire Zurn

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Category(s): Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Therapeutic Devices

Targeted Compression Stockings

Unmet NeedMore than 23% of all adults are thought to be affected by varicose veins. These veins are enlarged and swollen as a result of faulty valves that allow blood to flow in the wrong direction. Currently, varicose veins are managed through the application of a compression garment such as a stocking. The garments help prevent veins from being engorged...

Published: 3/13/2025 | Inventor(s): Andrew Schulick, Devika Singh

Keywords(s): Cardiovascular Diseases, Disease Indication, Other, Therapeutic Devices, Therapeutics

Category(s): Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Cardiovascular

Fluid Eluting Orthopaedic Implants with Chamber Empty Rate Determined through Topology Optimization

Unmet Need: The current designs of weightbearing orthopaedic implants are limited due to the variabilities in the material and structural properties of the bones in which they are implanted. In addition, many orthopaedic conditions -- and the implantation of foreign materials into the body -- are associated with significant risk of complications including...

Published: 3/14/2025 | Inventor(s): Jarred Bressner, Mikhail Osanov, Adam Levin

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Category(s): Technology Classifications > Medical Devices > Orthopedic Devices, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices

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