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Digital High Resolution Melt Microfluidic Platform and Assay for Assessing Locus-specific Molecular Heterogeneity of DNA Methylation

Value Proposition· Simple, low-cost microfluidic tool that evaluates DNA methylation using non-invasive liquid biopsy samples. · Allows for sensitive, specific evaluation of epigenetic biomarkers for early detection of cancer. · Includes software and algorithms for improved diagnostic interpretation of DNA methylation analyses. Unmet...

Published: 9/27/2024 | Inventor(s): Tza-Huei Wang, Christine O'Keefe, Thomas Pisanic

Keywords(s):

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Blood & Tissue Samples

Methods for Clearing and Molecular Analysis in Thick Tissue Sections

Unmet Need· Current techniques for in situ transcriptomics (or spatial transcriptomics) are effectively limited to thin tissue sections of approximately 15 microns due to the poor molecular diffusion and opacity of thicker tissues. Consequently, these techniques are unable to resolve spatial variation of transcription in 3D. Thus, there is a need...

Published: 9/27/2024 | Inventor(s): Reza Kalhor, Soichiro Asami

Keywords(s):

Category(s): Technology Classifications > Research Tools > Blood & Tissue Samples, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Specimen Handling, Technology Classifications > Research Tools > Assays

Multiplex Mass Spectrometry Assay on a Pentaflouropropyl (PFPP) Stationary Phase

Dried blood spot (DBS) tests are an important diagnostic tool used for newborns. Unfortunately DBS has a variety limitations. According to the CDC, approximately four million DBS tests are required for infants are born in the United States each year. Conventional newborn screening with DBS begins with the addition of capillary blood droplets from a...

Published: 9/27/2024 | Inventor(s): David Graham, Aurelie Roux, Robert Harlan

Keywords(s):

Category(s): Clinical and Disease Specializations > Hematology, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Research Tools > Blood & Tissue Samples, Technology Classifications > Diagnostics

A Novel, Organ-On-A-Chip Device for Assessing Trans-epithelial Transport, and Uses Thereof

Unmet NeedThe current drug development process is expensive, laborious, and only about 1 in 10 drugs that enter clinical trials ultimately receive FDA approval. One important factor that drives this high failure rate and the high costs associated with drug development is that traditional cell culture and animal-based methods for drug testing do not...

Published: 9/26/2024 | Inventor(s): Sean Sun, Mohammad Ikbal Choudhury

Keywords(s): Discovery/Research Tools, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Blood & Tissue Samples

Cord Blood Perfusion and Collection System

The present invention is a complete system for the collection of stem cells found within the umbilical cord and placenta vasculature. A strategy of the system is the use of perfusion in order to recover a larger yield of residual cells than what is currently recoverable. The invention is composed of three primary components: a hand-held sterile access...

Published: 9/26/2024 | Inventor(s): Mathew Means, Christopher Chiang

Keywords(s): Clinical Diagnostics, In Vitro Diagnostics, Interventional and Surgical Systems, Sample Collection Method, Surgical Instruments

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Blood & Tissue Samples

Human immunoglobulin purified from NMO-IgG positive patient plasma

Purified Human IgG Antibodies from Positive NMO- IgG PatientJHU REF: [C12575]Invention Novelty: This technology provides purified human IgG antibodies isolated from plasma cells from a Neuromyelitis Optica (NMO) positive patient. Value Proposition: NMO or Devic’s disease is a rare inflammatory disease in the optic nerves, and spinal cord where specific...

Published: 9/26/2024 | Inventor(s): Michael Levy

Keywords(s): Antibodies, Blood Samples, Buffer/Media Solution, Chronic Inflammatory Diseases, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Neurodegeneration, Neuromyelitis Optica, Neuromyelitis optica (NMO), Optic Neuritis, Polyclonal Antibodies, Research Reagent, Translational Research Biomarker

Human Blood Samples that Contain the Human Granulocytic Ehrlichia

C03088: Human Blood Samples that Contain the Human Granulocytic Ehrlichia Technical Details: Blood and serum samples from patients with corroborated HGE or HME. Blood samples contain antigens and nucleic acids of Anaplasma (Ehrlichia) phagocytophila (HGE) or Ehrlichia chaffeensis (HME); serum contains antibodies to A. phagocytophila (HGE) or Ehrlichia...

Published: 9/26/2024 | Inventor(s): J. Dumler

Keywords(s): Antibodies, Antiserum, Basic Research Biomarker, Blood Samples, Buffer/Media Solution, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Blood & Tissue Samples, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools