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A mRNA Lipid Nanoparticle Incorporated Nanofiber-hydrogel Composite to Generate a Local Immunostimulatory Niche for Immunotherapy

Value Proposition:· Creates a programmable immunostimulatory niche.· Allows for tailor-made immune responses to vaccines and antigens.· Flexible drug delivery platform enables mRNA therapeutics for infectious diseases and cancers.· Applicable to existing mRNA vaccines for improved efficacy. · Can be utilized for novel...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Zhicheng Yao, Christine Wei

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Research Tools > Microfluidics

An Exosome Display Spike Vaccine

Unmet NeedNext-generation vaccines are needed to address the emergence of new pathogens, the limitations of current vaccine technologies, and the need for more effective and durable immunity against complex diseases like cancer, HIV, and emerging viruses. Traditional vaccines require long production timelines, often require cold storage, multiple doses,...

Published: 3/14/2025 | Inventor(s): Stephen Gould, Chenxu Guo, Shang-Jui Tsai

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Vaccines

A DNA Vaccine for Eliciting T Cell Immunity in the Lung

Unmet NeedRespiratory pathogens are a major contributor to global economic and public health crises. In the wake of the COVID-19 pandemic, new vaccine technologies have been developed to improve the response to emerging pathogens. However, questions remain regarding how to deal with pathogens that have the potential to cause future pandemics. New vaccination...

Published: 3/14/2025 | Inventor(s): Richard Markham, James Gordy, Petros Karakousis

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Technology Classifications > Therapeutic Modalities > Vaccines

Polymeric Vaccine for Opioid Addiction

Value Proposition:· Elicits production of anti-Fentanyl antibodies· Leads to long-lasting anti-opioid responses without toxicity· Exhibits 1000-fold increase in antibody production over conventional drug vaccines Technology DescriptionResearchers at Johns Hopkins have developed a polymeric fentanyl vaccine. Upon a primary injection and...

Published: 3/14/2025 | Inventor(s): David Wilson, Sandeep Kumar

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Pain, Clinical and Disease Specializations > Psychiatry > Addiction

A Vaccine to Reduce Treatment Time for Tuberculosis

Unmet NeedTuberculosis (TB) is one of the leading causes of death globally. A vaccine to prevent TB has not been approved since the development of the BCG vaccine in the early 20th century. New treatment paradigms using small molecule antibiotics have led to cures in a large proportion of individuals with drug-susceptible TB. The course of treatment...

Published: 3/14/2025 | Inventor(s): Richard Markham, Petros Karakousis, Styliani Karanika, James Gordy, Yu-Min Chuang

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)

Polymeric Nanoparticle Genetic Vaccines

Value PropositionVersatile immunotherapy platform with the ability to specifically target antigen presenting cells (APCs) ) following systemic delivery and without requiring targeting ligands to improve treatment efficacy. Flexibility to modulate the immune system through activation or inducing tolerance.Useful as a preventative strategy or therapeutic...

Published: 3/14/2025 | Inventor(s): Jordan Green, Elana Ben-Akiva, Johan Karlsson, Stephany Tzeng, Kelly Rhodes, Sarah Neshat

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Compositions and Methods of Increasing RNA Translation

Value Proposition mRNA use for therapeutic purposes has proven useful in treating a wide array of diseases. Major challenges of mRNA therapies include immunogenicity, poor expression, and low stability. This therapy contains modifications improving mRNA stability, efficiency, and immunogenicity. This technology allows for the translation of almost...

Published: 3/14/2025 | Inventor(s): Jeffery Coller, Zachary Mandell

Keywords(s):

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Vaccines

Peptide for the Prevention and Treatment of Coronavirus Infection

Value Proposition· Peptide-based supramolecular filament that attenuates SARS-CoV virus infectivity in vivo· Leverages ACE2 enzyme-substrate docking activity· Enables therapeutic protein delivery in repairable aerosolsUnmet Need· Respiratory illnesses, including tuberculosis, influenza, and COVID-19, pose a significant worldwide...

Published: 3/14/2025 | Inventor(s): Honggang Cui, Hongpeng Jia, Caleb Anderson

Keywords(s):

Category(s): Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

A T-cell Vaccine for SARS Virus

Unmet Need· In response to the global COVID-19 pandemic, a variety of vaccines have been rapidly developed to prevent serious illness or death from infection by SARS-CoV-2. The gold standard are mRNA vaccines which deliver mRNA to make copies of the SARS-CoV-2 spike protein, which ultimately activates immunes cells to produce antibodies against...

Published: 3/14/2025 | Inventor(s): Maxim Rosario, Bette Korber

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Vaccines

Reprogramming Aluminum Adjuvants to Tailor Immune Response

Unmet NeedVaccination is an important public health intervention that has led to the rapid decline of many infectious diseases. To maximize safety and minimize reactogenicity, vaccine development is gradually shifting from whole, inactivated vaccines to well defined subunit vaccines. However, this approach often suffers from reduced immunogenicity....

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Gregory Howard

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Immunology, Technology Classifications > Therapeutic Modalities > Vaccines

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