Search Results - yihao+liu

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Polymers for Binding-Triggered Antibody Precipitation and Purification

Value PropositionResults in >97% precipitation yield, >88% elution yield of mAbsSimplified molecular design compared to elastin-like polypeptide (ELP)-based materialsDoes not need additional salt to achieve mAb precipitation and recoveryTechnology DescriptionResearchers at Johns Hopkins have developed a peptide-based platform technology using...

Published: 6/28/2024 | Inventor(s): Honggang Cui, Yi Li, David Stern, XuanKuo Xu, Lye Lin Lock, Jason Mills, Sanchayita Ghose, Zheng Jian Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

A Novel Supramolecular High Affinity Protein-Binding System for Purification of Biomacromolecules

Market hold: no patent application filed for this invention.Unmet Need· It is estimated that between ~50-80% of costs in antibody production are spent in purification (Mustafaoglu et al. 2016), which is typically performed by affinity chromatography. Although this method has adequate binding affinity and selectivity, the process remains costly...

Published: 6/27/2024 | Inventor(s): Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li

Keywords(s): Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics > Biomarkers

Growth and Site-specific Organization of Micro-scale Bimolecular Devices on Living Mammalian Cells

Unmet Need: One aspect of a cell’s function is its ability to form organized structures both within the cell and with its immediate surrounding environment. On cell surfaces, these nanostructures can serve as scaffolds or operate functionally to aid in cellular fate decisions, signal amplification and cellular cross-talk. There is a need to understand...

Published: 6/28/2024 | Inventor(s): Rebecca Schulman, Sisi Jia, Siew Cheng Phua, Yuta Nihongaki, Yizeng Li, Michael Pacella, Yi Li, Abdul Majeed Mohammed, Sean Sun, Takanari Inoue

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Layer boundary evolution for macular OCT segmentation

Unmet NeedOptical coherence tomography (OCT) is a three-dimensional (3D) imaging technique that emits a beam of light into the tissues to be examined and detects the reflected or back-scattered light from the tissues. OCT produces high-resolution depth images of the retina and is now the standard of care for in vivo ophthalmological assessment. It is...

Published: 6/28/2024 | Inventor(s): Jerry Prince, Aaron Carass, Yihao Liu

Keywords(s): Computer and Network Systems, Computer Software, Image Analysis Software, Image Processing Software, Imaging and Sensing Systems, In Vivo Medical Imaging

Category(s): Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis

Approaches to Engineering Self-Assembling Peptide Filaments for Protein Binding and Purification

Unmet NeedPeptide amphiphiles (PA) are engineered biomaterials that can self-assemble into nanostructures with specific functions, such as binding to biomarkers for a variety of diseases, binding to specific proteins for purification purposes, or for binding to location specific regions for locally administering drugs. Most PAs currently synthesized...

Published: 6/27/2024 | Inventor(s): Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Reagent

Category(s): Technology Classifications > Research Tools

Large Deflection Shape Sensor and Method of Use for Dexterous Continuum Manipulators

The present invention generally relates to dexterous continuum manipulator (DCM) shape sensing and, more particularly, to large deflection shape sensing for DCM. DCMs have found a variety of applications in robotic surgery in general and, specifically, in minimally-invasive surgery (MIS). These DCMs typically assist surgeon in diagnosis and/or operating...

Published: 6/27/2024 | Inventor(s): Hao Liu, Amirhossein Farvardin, Mehran Armand, Russell Taylor, Iulian Iordachita

Keywords(s): Interventional and Surgical Systems, Robotic Surgical System Sensing, Surgical Control Systems, Surgical Instruments, Surgical Navigation

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices