Search Results - clinical+and+disease+specializations+%3e+nephrology+%3e+polycystic+kidney+disease

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Cystic Fibrosis Transmembrane Conductance Regulator Modulators for Treating Autosomal Resessive Polycystic Kidney Disease

Unmet Need / Invention Novelty: Autosomal recessive polycystic kidney disease (ARPKD) patients that survive beyond neonatal age face various comorbidities that progress into chronic liver disease and end stage kidney disease. There is no cure for ARPKD and current treatments are limited to supportive treatments that manage symptoms and preserve kidney...

Published: 9/27/2024 | Inventor(s): Liudmila Cebotaru

Keywords(s):

Category(s): Clinical and Disease Specializations > Nephrology > Polycystic Kidney Disease, Technology Classifications > Therapeutic Modalities > Targets

Polyclonal Chicken and Rabbit Antibodies, Termed Anti-CC, Generated Using Denatured C-terminal 199 Amino Acid Fragment of Mouse Polycystin-1 Protein as Immunogen

TITLE Polyclonal chicken and rabbit antibodies, termed anti-CC, of mouse polycystin-1 protein as immunogenC13399ABSTRACTPolycystin-1 (PC1) has an essential function in renal tubular morphogenesis and disruption of its function causes cystogenesis in human autosomal dominant polycystic kidney disease. Endogenous...

Published: 9/26/2024 | Inventor(s): Feng Qian

Keywords(s): Antibodies, Basic Research Biomarker, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, In Vivo Research Tool, Kidney Disorders, Polyclonal Antibodies, Polycystic Kidney Disease, Rabbit Model, Rabbit Model Xenograft, Research Reagent, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools, Clinical and Disease Specializations > Nephrology > Polycystic Kidney Disease

Pkd1(superscript ko) Mouse Line (Pkd1[superscript tm1Ggg]; it is also known as Pkd1[superscript beta-gal-null])

C10754: Mouse Model For Polycystic Kidney Disease Gene KnockoutNovelty: This technology is a mutant mice containing beta-galactosidase instead of Pkd1 gene to study the pathogenesis of autosomal dominant polycystic kidney disease.Value Proposition: Autosomal dominant polycystic kidney disease is characterized by cyst formation in the kidney and other...

Published: 9/26/2024 | Inventor(s): Klaus Piontek, Gregory Germino

Keywords(s): Basic Research Biomarker, Biomarker, Cell Lines, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, In Vivo Research Tool, Kidney Disorders, Knock Out Mouse Model, Mouse Cell Lines, Mouse Model, Polycystic Kidney Disease

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Nephrology > Polycystic Kidney Disease, Technology Classifications > Diagnostics > Biomarkers