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A DNA methylation and genotype specific biomarker of suicide attempt
Novel Biomarkers for Predicting Suicide RiskJHU REF: [C12394]Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting suicide risk. Value Proposition: Almost 30,000 people die of suicide each year in the United States, and 1 million people die worldwide. In the teenage population, it is the second leading cause of...
Published: 3/13/2025
|
Inventor(s):
Holly Wilcox
,
Zachary Kaminsky
Keywords(s):
Biomarker
,
Clinical Diagnostics
,
CNS and Neurological Disorders
,
Disease Indication
,
Epigenetic
,
In Vitro Diagnostics
,
In Vitro Diagnostics (Old)
,
Methylation
,
Prognostic Biomarker
,
Psychiatric Diseases
,
Suicidal Impulses
,
Suicide/Suicidal Impulses
Category(s):
Clinical and Disease Specializations
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Technology Classifications > Diagnostics
,
Clinical and Disease Specializations > Psychiatry
,
Clinical and Disease Specializations > Psychiatry > Suicidal Impulses
DNA Methylation Biomarkers of Post Partum Depression Risk
Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting postpartum depression (PPD) risk . Value Proposition: PPD occurs in approximately 10-15% of women and represents a serious health risk to both mothers and their offspring. Increased depression risk in pregnant women is not predicted by hormonal fluctuations. This...
Published: 3/13/2025
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Inventor(s):
Zachary Kaminsky
,
Jennifer Payne
,
Todd Gould
Keywords(s):
Biomarker
,
Clinical Diagnostics
,
CNS and Neurological Disorders
,
Disease Indication
,
In Vitro Diagnostics
,
Post Partum Depression
,
Postpartum Depression
,
Prognostic Biomarker
,
Psychiatric Diseases
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Women's Health
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Technology Classifications > Diagnostics
,
Clinical and Disease Specializations > Psychiatry
,
Clinical and Disease Specializations > Psychiatry > Postpartum Depression
Targeted Epigenetic Therapy against Distal Regulatory Element of TGFB2 Expression for Scleroderma and Fibrotic Disease
Unmet NeedScleroderma disorders comprise a heterogeneous group of conditions linked by the presence of thickened, sclerotic skin lesions. These conditions result in a poor quality of life and have a poor prognostic outcome. In particular, systemic sclerosis (SSc) has a 10 year mortality rate of approximately 30%. However, the pathogenic mechanisms of...
Published: 3/13/2025
|
Inventor(s):
Harry Dietz
,
Joseph Shin
Keywords(s):
Biomarker
,
Clinical Diagnostics
,
Diagnostic Biomarker
,
Disease Indication
,
Fibrosis Disorders
,
In Vitro Diagnostics
,
Prognostic Biomarker
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Fibrosis
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > Diagnostic Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Technology Classifications > Therapeutic Modalities
,
Technology Classifications > Diagnostics
Angiotensin Type 1 Receptor Autoantibody in Wound Healing
Unmet Need:Chronic wounds are among the most common, painful, debilitating and costly conditions in diabetics and in older adults, and are an important portal for bacterial infections that often lead to amputations, sepsis and mortality. In diabetic and aging skin, chronic inflammation commonly accompanies poor wound healing and increases the risk for...
Published: 3/13/2025
|
Inventor(s):
Peter Abadir
,
Jeremy Walston
,
Alka Jain
,
Neal Fedarko
Keywords(s):
Biomarker
,
Clinical Diagnostics
,
Disease Indication
,
In Vitro Diagnostics
,
Prognostic Biomarker
,
Wound Healing
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Wound Healing
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Technology Classifications > Therapeutic Modalities > Targets
,
Technology Classifications > Diagnostics
,
Technology Classifications > Therapeutic Modalities
Method to Determine Risk of Developing PTSD after Stressful Events
Unmet Need:Post-traumatic stress disorder (PTSD) is recognized by the Department of Defense, the Department of Veterans Affairs, and the National Institute of Mental Health as a major medical issue for both deployed and returning U.S. troops. PTSD rates in military personnel following deployment range from 5 to 15% (Sundin et al, 2010; Reijnen et al,...
Published: 3/13/2025
|
Inventor(s):
Zachary Kaminsky
,
Marco Boks
Keywords(s):
Biomarker
,
Clinical Diagnostics
,
CNS and Neurological Disorders
,
Disease Indication
,
In Vitro Diagnostics
,
Post-Traumatic Stress Disorder
,
Post-Traumatic Stress Disorder (PTSD)
,
Prognostic Biomarker
,
Psychiatric Diseases
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Psychiatry > Post-Traumatic Stress Disorder
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Technology Classifications > Diagnostics
,
Clinical and Disease Specializations > Psychiatry
Prognostic Markers in Pancreatic Cancer
TITLE: GENOMIC ALTERATIONS IN THE TUMOR AND CIRCULATION OF PANCREATIC CANCER PATIENTSCASE NUMBER: C13433UNMET NEEDSeveral genetic alterations have been identified in pancreatic cancers, including those in certain tumor suppressor genes and in oncogene. Although the discoveries of these genes and their pathways have provided important insights into...
Published: 3/13/2025
|
Inventor(s):
Victor Velculescu
,
Mark Sausen
,
Vilmos Adleff
,
Jillian Phallen
Keywords(s):
Biomarker
,
Cancers
,
Clinical Diagnostics
,
Disease Indication
,
In Vitro Diagnostics
,
Pancreatic Cancer
,
Prognostic Biomarker
,
Therapeutic Matter
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Gastroenterology
,
Clinical and Disease Specializations > Oncology > Pancreatic Cancer
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostic Biomarkers
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Technology Classifications > Diagnostics
,
Clinical and Disease Specializations > Oncology
Glioblastoma Biomarker for Improved Survival Prediction
TITLE: Glioblastoma Biomarker for Improved Survival PredictionCASE NUMBER: C13155UNMET NEEDGlioblastoma GBM), the most common primary brain tumor, has few available therapies providing significant improvement in survival. The median survival of patients after treatment is ~15 months, with only 3-5% surviving longer than 3 years. However, survival varies...
Published: 3/13/2025
|
Inventor(s):
Patrick Ha
,
Michael Lim
,
Chetan Bettegowda
,
Taeyoung Hwang
,
Chul-Kee Park
,
Dimitrios Mathios
Keywords(s):
Biomarker
,
Brain Cancer
,
Breast Cancer
,
Cancers
,
Cervical Cancer
,
Clinical Diagnostics
,
Disease Indication
,
Glioma
,
In Vitro Diagnostics
,
Lung Cancer
,
Prognostic Biomarker
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Neurology
,
Clinical and Disease Specializations > Oncology
,
Clinical and Disease Specializations > Oncology > Brain Cancer
,
Clinical and Disease Specializations > Oncology > Breast Cancer
,
Clinical and Disease Specializations > Oncology > Cervical Cancer
,
Clinical and Disease Specializations > Oncology > Glioma
,
Clinical and Disease Specializations > Oncology > Lung Cancer
,
Clinical and Disease Specializations > Respiratory Diseases
,
Clinical and Disease Specializations > Women's Health
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Technology Classifications > Diagnostics
Biomarkers of Pulmonary Hypertension
C11797: Blood Test Biomarkers for Pulmonary Arterial HypertensionNovelty: This invention is a novel set of circulating biomarkers found in serum and plasma which can be used for diagnostic and prognostic testing of Pulmonary Arterial Hypertension (PAH).Value Proposition: Currently, the first line of treatment for PAH is prescribing vasodilators, which...
Published: 3/13/2025
|
Inventor(s):
Zongming Fu
,
Allen Everett
Keywords(s):
Biomarker
,
Cardiovascular Diseases
,
Clinical Diagnostics
,
Diagnostic Biomarker
,
Disease Indication
,
Hypertension
,
In Vitro Diagnostics
,
Prognostic Biomarker
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Cardiovascular > Hypertension
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > Diagnostic Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Clinical and Disease Specializations > Cardiovascular
,
Technology Classifications > Diagnostics
Methylation markers for stratifying breast cancer, for prognosis, for predicting disease recurrence and response to treatment
C11625: Markers to Differentiate between ER Subtypes, Predict Treatment Outcome and Risk of Reoccurrence in Breast Cancer Value Proposition: - 40 loci have been validated in an independent dataset. - This technology may reveal important biological differences in the epigenome between breast cancer subtypes. - These markers may provide ancillary clinical...
Published: 3/13/2025
|
Inventor(s):
Mary jo Fackler
,
Leslie Cope
,
Antonio Wolff
,
Peng Huang
,
Zhe Zhang
,
Christopher Umbricht
,
Kala Visvanathan
,
Saraswati Sukumar
Keywords(s):
Biomarker
,
Breast Cancer
,
Cancers
,
Clinical Diagnostics
,
Disease Indication
,
In Vitro Diagnostics
,
Pharmakodynamic Biomarker
,
Prognostic Biomarker
,
Risk Stratification
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Oncology > Breast Cancer
,
Clinical and Disease Specializations > Women's Health
,
Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Technology Classifications > Computers, Electronics & Software
,
Technology Classifications > Diagnostics
,
Clinical and Disease Specializations > Oncology
Biomarkers for Aggressive Prostate Cancer
C11470: Biomarkers for Aggressive Prostate CancerNovelty: This technology comprises the discovery of novel biomarkers which could be useful for cancer diagnosis and monitoring the treatment of aggressive prostate tumor.Value Proposition: Existing technologies fail to reliably distinguish aggressive prostate cancer from non-aggressive prostate cancer....
Published: 3/13/2025
|
Inventor(s):
Daniel Chan
,
Yuan Tian
,
Jing Chen
,
Hui Zhang
Keywords(s):
Biomarker
,
Cancers
,
Clinical Diagnostics
,
Disease Indication
,
In Vitro Diagnostics
,
Prognostic Biomarker
,
Prostate Cancer
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Men's Health
,
Clinical and Disease Specializations > Oncology > Prostate Cancer
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Technology Classifications > Diagnostics
,
Clinical and Disease Specializations > Oncology
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