Search Results -

2095 Results

Sort By:

A Method to Conditionally Deliver Effector Proteins to Plasma and Endosomal Membranes in Response to Tyrosine Kinase Signaling

JHU Ref #: C17482Value Proposition· Effective & Targeted: Harnesses endogenous pain signaling via receptor tyrosine kinases to conditionally deliver effector proteins to the plasma membrane, enabling suppression of chronic pain under pathological conditions· Broadly Applicable: Enables modular, tunable therapy tailored to the prevailing...

Published: 6/27/2025 | Inventor(s): Michael Caterina, Stephen Gould, Shang-Jui Tsai

Keywords(s):

Category(s):

Repurposing Thiazolidinedione for the Treatment of Muscular Dystrophies

JHU Ref #: C17163Value Proposition· Improves specific isometric force and muscle-fiber cross-sectional area.· Reduces necrosis and inflammation in early disease, as well as diaphragm fibrosis in advanced disease. · Doubles the proportion of dystrophin-positive fibers and nearly doubles functional endurance when combined with AAV...

Published: 6/27/2025 | Inventor(s): Laszlo Nagy, Lee Sweeney, David Hammers, Andreas Patsalos

Keywords(s):

Category(s):

Network Toughening by Silicon-doped Crosslinkers

Molecular Crosslinking Strategy for Network TougheningJHU Ref #: C18642Value Proposition:· Includes: increasing polymer network toughness through a novel chemical modification.· Enables stronger, durable 3D-printed materials.· Adaptable to modern 3D printing platforms for improved production from existing machinery.Unmet Need:Polymer...

Published: 6/27/2025 | Inventor(s): Rebekka Klausen, Sophia Melvin, Stephen Craig, Yunxin Yao, Rowina Bell, Alshakim Nelson, Heather Kulik, Ilia Kevlishvili, Xiao Huang

Keywords(s):

Category(s):

Lipid Nanoparticle Formulations Capable of Migrating to Systemic Organs Following Intramuscular Administration

Value Proposition:Organ-targeted drug or mRNA delivery to focus therapy on specific tissues. Accessible intramuscular administration, offering broadly applicable, out-of-the-box drug delivery system for a range of therapeutics.Achieves organ-specific delivery without antibodies or targeting ligands, simplifying manufacturing and scalability.Unmet NeedTargeting...

Published: 6/27/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Christine Wei, Di Yu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Rechargeable Hydrogen Battery

Value Proposition· Nearly carbon-neutral energy storage· Charging: Ability to achieve rapid charging · Size: Sizing allows for use in plane, railroad, or oceanic travel settings. Unmet Need· Lithium batteries see use a wide variety of technologies, ranging from portable electronics to electric vehicles. While there has been improvements...

Published: 6/27/2025 | Inventor(s): Chao Wang, Hao Shen, Chengao Zhou, Zimin He

Keywords(s):

Category(s):

Photoacoustic Imaging Platform for Intraoperative Evaluation and Treatment of Peripheral Nerve Injuries

Value Proposition:Highly accurate and objective determination of nerve injury site during surgical operations.Reduces patient risk during nerve surgeries by improving upon existing rudimentary methods.Quantifies nerve regeneration potential for a prognosis of patient recovery.Accessible and mobile imaging device for intraoperative use or postoperative...

Published: 6/27/2025 | Inventor(s): Muyinatu Bell, Michelle Graham, Nicholas von Guionneau, Sami Tuffaha

Keywords(s):

Category(s):

Methods and Markers for Predicting Tumor Behavior and Metastatic Risk in Epithelial Malignancies

Value Proposition: Early detection of metastatic cancer: Accurately predicts metastatic cancer risk potential by detection of specific biological markers in patient tumors. Applicability across multiple cancer types: Cancer biomarker detection technology that can be potentially applied to epithelial tumors including colon, breast, and prostate. Improved...

Published: 6/27/2025 | Inventor(s): Reza Kalhor, Jesse Handler

Keywords(s):

Category(s): Technology Classifications > Diagnostics

GCPII Inhibition for the Treatment of Sarcopenia and Aging

Unmet Need:Sarcopenia is the progressive loss of muscle mass and function, and is a natural part of the aging process. Age-related muscle loss and weakness can contribute to frailty and increase the likelihood of falls and fractures in older adults. Recent reports found that 5-13% of persons over the age of 65 years and >50% of people 80 years and...

Published: 6/27/2025 | Inventor(s): Barbara Slusher, Carolyn Tallon

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Geriatrics

Compositions and Biomarkers for Human Cancer and Methods of Use

Novel biomarkers for the detection and prognosis of several cancersJHU REF: C12506 Invention novelty: This invention has discovered high frequency mutations in the telomerase reverse transcriptase (TERT) promoter of certain cancers. Value Proposition: Early detection is usually critical for the successful treatment of cancer, therefore there is...

Published: 6/26/2025 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Chetan Bettegowda, Yuchen Jiao, Darell Bigner, Hai Yan, Zachary Reitman, Patrick Killela

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Predictive Algorithm for the Optimization and Individualization of Clinical Management

Unmet Need:There are many complex clinical scenarios for which the ability to predict and then optimize patient outcomes at an individual level could be beneficial. These include direct individualization of therapy for patient (i.e. bedside decision support systems) and the optimization of the design of clinical trials by providing an in-silico simulation...

Published: 6/27/2025 | Inventor(s): Cedric Manlhiot, Shelby Kutty, Bhargava Kumar Chinni, Jason Hearn

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Clinical Management

1 2 3 4 5 6 7 8 9 10 ...