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Long Term Storage and Improved Mechanical Properties of Implantable Vascular Grafts

Technical Problem Current synthetic small-diameter tissue engineered vascular grafts face challenges such as thrombogenicity, decreased elasticity, aneurysmal failure, calcification, and intimal hyperplasia, limiting their clinical effectiveness for pediatric congenital cardiovascular defects, coronary artery disease, and peripheral artery disease,...

Published: 1/27/2026 | Inventor(s): Sharon Gerecht, Morgan Elliott, Hai-Quan Mao, Jessica Shen

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities > Tissue Substrates, Technology Classifications > Medical Devices > Cardiology

Methods and Systems for Insertion of a Medical Device during a Medical Imaging Process

Technical Problem Current medical procedures for prostate biopsy and therapy face challenges with inaccurate needle placement due to dynamic tissue deformation and limited access within closed MRI scanners, where traditional robots and mechanical linkages are not compatible and suffer from low signal-to-noise ratio and invasive methods. How it...

Published: 1/27/2026 | Inventor(s): Gabor Fichtinger, Iulian Iordachita, Louis Whitcomb, Robert Susil, Ergin Atalar, Axel Krieger

Keywords(s): Interventional and Surgical Systems, Surgical Navigation

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices

Abdominal Multi-Organ Segmentation with Organ-Attention Networks

Value Proposition· Higher accuracy: Uses a novel organ-attention mechanism to reduce false positives and improve organ boundaries· Integrated view predictions: Utilizes axial, sagittal, and coronal images to produce robust and consistent organ labels· Rapid approach: Utilizes accessible GPU hardware over stronger, but slower, alternatives· Highly...

Published: 1/22/2026 | Inventor(s): Alan Yuille, Elliot Fishman, Seyoun Park, Yan Wang, Yuyin Zhou, Wei Shen

Keywords(s): Computer and Network Systems, Computer Software, Image Analysis Software

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis

PSMA-targeted Nanoparticles for Therapy of Prostate Cancer

PSMA-targeting nanoparticle for prostate cancer therapyJHU Ref #: C10180Value Proposition:· Engineered nanoparticle system with potent urea-based PSMA inhibitor· Drug loaded nanoparticle· Specific and selective tumor cytotoxicity Unmet NeedProstate cancer affects millions of men globally and is a leading cause of cancer death in...

Published: 1/22/2026 | Inventor(s): Martin Pomper, Ronnie Mease, Sachin Chandran, Sangeeta Ray, Samuel Denmeade

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Prostate Cancer, Single, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Prostate Cancer

A CRISPR-based technology to treat cytomegalovirus (CMV) and other Viral Infections.

Value PropositionNovel Mechanism: Utilizes a Crispr/Cas9 system to target the viral genome to prevent production of the disease-causing protein 1E1.Widely Adaptable: Design allows modulation to fit a wide variety of other viral genomes to combat other infectious diseases.Therapeutic Potential: Administration of proposed technology to infected pregnant...

Published: 1/22/2026 | Inventor(s): Akira Sawa, Koko Ishizuka, Kazuhiro Ishii, Stephanie Tankou

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Cytomegalovirus, Technology Classifications > Therapeutic Modalities > Gene Therapies

MS-cleavable Photo-crosslinkers for Proteome-wide Photo-crosslinking Mass Spectrometry

Reagents for Crosslinking Mass SpectrometryJHU Ref #: C17605 Value Proposition:• MS-cleavable crosslinkers for capturing protein-protein interactions. • Compounds feature an NHS group and diazirine for covalent non-specific residue linkages.• Avoid the N2 problem. • Compounds are water-soluble and cell-permeable. Technology DescriptionResearchers at...

Published: 1/22/2026 | Inventor(s): Piyoosh Sharma, Stephen Fried, Anneliese Faustino

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Peptides

The Role of IL17 in Age-related Immune-stromal Network Inhibiting Response to Regenerative Immunotherapy

Combination immunotherapy to enhance tissue regeneration in the elderly JHU Ref #: [C17006] Value Proposition· Regenerative medicine strategies aim to restore or replace damaged tissues and organs, with patients suffering from chronic diseases, injuries, and degenerative conditions as the end-users of regenerative medicine therapies.· Current...

Published: 1/22/2026 | Inventor(s): Jennifer Elisseeff, Jin Han, Christopher Cherry, Drew Pardoll

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Traumatic Injury, Clinical and Disease Specializations > Wound Healing

INCERTS Methodology for Multiplexing Single Cell Analyses via cDNA Barcoding

A method for integrating cellular phenotype with T cell receptor analysisJHU Ref #: C17820 Value Proposition:· Paired TCR sequencing and phenotypic analysis· High throughput and resolution· Enables pooling of samples Unmet NeedCharacterization of the adaptive immune response has been advanced by single cell RNA-sequencing (scRNA-seq)...

Published: 1/22/2026 | Inventor(s): Harry Larman, Janelle Montagne, Sahana Jayaraman

Keywords(s):

Category(s): Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

A Method and System for Estimating Aneurysmal Occlusion Resulting from Flow Diverting Stents

Predictive model for individualized stent placement to improve patient outcomes.JHU Ref #: C17923 Value Proposition:• Technology generates individualized prediction of graft success for a given patient• Model performs an evaluation of stent design (i.e. porosity, material) and predicts individualized flow dynamics measurements • Assesses the need for...

Published: 1/22/2026 | Inventor(s): Rajat Mittal, Jung Hee Seo, Justin Caplan, Zulfikar Alamlah, Luis Gonzalez, Angad Grewal

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular > Aneurysm, Technology Classifications > Computers, Electronics & Software > Algorithms

Immune Cell Modulation using Phosphodiesterase Activating Drug

Value PropositionAdjuvant to support the widespread use of immunotherapy in cancer.May improve the responses to checkpoint inhibitors (Keytruda) or CAR T cell activity.Diverse applications as a supplement to various precision cancer therapies.Repurposes a commercially available chemical compound for cancer treatment.Scalable synthesis, given the existing...

Published: 1/22/2026 | Inventor(s): Christopher Jackson, Landon Hansen, Eli Yazigi, Henry Brem

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology

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