Search Results - clinical+and+disease+specializations+%3e+immunology

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Immune Cell Modulation using Phosphodiesterase Activating Drug

Value PropositionAdjuvant to support the widespread use of immunotherapy in cancer.May improve the responses to checkpoint inhibitors (Keytruda) or CAR T cell activity.Diverse applications as a supplement to various precision cancer therapies.Repurposes a commercially available chemical compound for cancer treatment.Scalable synthesis, given the existing...

Published: 1/22/2026 | Inventor(s): Christopher Jackson, Landon Hansen, Eli Yazigi, Henry Brem

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology

Method of enhancing anti-inflammatory properties of extracellular vesicles

Value Proposition· Promotes adenosine production to inhibit proinflammatory cytokine release· Promotes regulatory T cells expansion· Suppresses effector immune responses· Amplifies a natural, local anti-inflammatory signal, which lowers risk of unintended side effects· Targets specific inflammatory microenvironments to minimize...

Published: 1/22/2026 | Inventor(s): Kenneth Witwer, Matias Ostrowski, Paula Soledad Perez, Tomas Grosso, Martina Fabiano

Keywords(s):

Category(s): Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Inflammation > Chronic Inflammatory Diseases

System for Enhancing Stem Cell Growth & Development Using Fluid Viscosity to Support Tissue Regeneration and Engraftment

Value Proposition· Preserve bone-forming potential (osteogenic phenotype) in soft tissue environments· Reduces immune rejection by promoting an immunosuppressive macrophage response· Enables preconditioning of stem cells for enhanced engraftment success· Applicable to a wide range of regenerative medicine and tissue engineering therapies· Introduces...

Published: 1/22/2026 | Inventor(s): Konstantinos Konstantopoulos, Alice Amitrano, Qinling Yuan, Bhawana Agarwal, Luo Gu, Jude Phillip, Yoseph Dance, Yi Zuo

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Stem Cells

Targeted chemo-immunotherapy delivery

Value PropositionEnhanced effect of immunotherapyTreatment for recurrent or metastatic diseaseImproved glioma treatment Unmet NeedImmunotherapy represents a new paradigm in cancer treatment. Molecules that effectively reverse the immune suppressing nature of cancer have the potential to enhance the body’s ability to work systemically combat cancer (Pardoll,...

Published: 1/22/2026 | Inventor(s): Dimitrios Mathios, Betty Tyler, Drew Pardoll, Henry Brem, Michael Lim

Keywords(s): Antagonists/Inhibitors, Cancers, Chemotherapy/Immunotherapy, Combination, Disease Indication, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities

Polymers and Nanoparticles for Intramuscular Nucleic Acid Delivery

Value Proposition:· Platform technology for prophylactic and therapeutic vaccination with large RNA payloads.· Can deliver several types of nucleic acid payloads including self-amplifying mRNA, plasmid, linear DNA, siRNA, miRNA, mRNA.· Adaptable as a therapeutic delivery strategy for genetic, musculoskeletal, and neurological disorders.Unmet Need:Vaccinology...

Published: 1/22/2026 | Inventor(s): Jordan Green, David Wilson, Stephany Tzeng, Yuan Rui, Sarah Neshat, Kathryn Luly

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Infectious Diseases

Nanoparticles for Delivery of Immunoregulatory Materials to T Cells

Value Proposition:· This platform improves current methods for expansion of CD4+ T-cells, which could be used in adoptive transfer therapies.· Improves modulation, activation, and expansion of T cells over current methods used for CAR T-cell therapyTechnology Description· Researchers at Johns Hopkins have developed a nanoparticle-based...

Published: 1/22/2026 | Inventor(s): Jonathan Schneck, Ariel Isser, Si-Sim Kang

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Oncology, Technology Classifications > Engineering Tech, Technology Classifications > Therapeutic Modalities

Novel Therapeutic Drug for Multiple Sclerosis

INVENTION NOVELTY This molecule, through its action on a unique target that is different from current therapeutic treatments for MS, has both immunosuppressive and neuromodulatory properties that will better prevent the progression of MS and repair the neuronal damage caused by the immune cells in MS. Currently, there are no MS drugs in the market...

Published: 1/22/2026 | Inventor(s): Paul Kim, Michael Kornberg, Peter Calabresi, Solomon Snyder

Keywords(s): Chronic Inflammatory Diseases, CNS and Neurological Disorders, Disease Indication, Multiple Sclerosis, Multiple Sclerosis (MS), Neurodegeneration, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Polymers for Binding-Triggered Antibody Precipitation and Purification

Value PropositionResults in >97% precipitation yield, >88% elution yield of mAbsSimplified molecular design compared to elastin-like polypeptide (ELP)-based materialsDoes not need additional salt to achieve mAb precipitation and recoveryTechnology DescriptionResearchers at Johns Hopkins have developed a peptide-based platform technology using...

Published: 1/22/2026 | Inventor(s): Honggang Cui, Yi Li, David Stern, XuanKuo Xu, Lye Lin Lock, Jason Mills, Sanchayita Ghose, Zheng Jian Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

Polymeric Nanoparticle Genetic Vaccines

Value PropositionVersatile immunotherapy platform with the ability to specifically target antigen presenting cells (APCs) ) following systemic delivery and without requiring targeting ligands to improve treatment efficacy. Flexibility to modulate the immune system through activation or inducing tolerance.Useful as a preventative strategy or therapeutic...

Published: 1/22/2026 | Inventor(s): Jordan Green, Elana Ben-Akiva, Johan Karlsson, Stephany Tzeng, Kelly Rhodes, Sarah Neshat

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Albumin-Flt3L Fusion Protein to Enhance Anti-Tumor Immunity and Antigen-specific T-cell Cytotoxicity

Unmet Need: Active immunotherapy, such as anti-PD-1/PD-L1 and anti-CTLA-4 checkpoint blockage, involves the administration of molecules to mobilize host immune cells to recognize and kill tumors. Proper presentation of tumor antigens through antigen presenting cells is a prerequisite to elicit a potent immune response. Current strategies enhance antigen...

Published: 1/22/2026 | Inventor(s): T.c. Wu, Chien-Fu Hung, Brandon Lam

Keywords(s): Biologics, Cancers, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Research Instrument, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Immunology, Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Targets

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