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Methods and Markers for Predicting Tumor Behavior and Metastatic Risk in Epithelial Malignancies

Value Proposition: Early detection of metastatic cancer: Accurately predicts metastatic cancer risk potential by detection of specific biological markers in patient tumors. Applicability across multiple cancer types: Cancer biomarker detection technology that can be potentially applied to epithelial tumors including colon, breast, and prostate. Improved...

Published: 6/27/2025 | Inventor(s): Reza Kalhor, Jesse Handler

Keywords(s):

Category(s): Technology Classifications > Diagnostics

Compositions and Biomarkers for Human Cancer and Methods of Use

Novel biomarkers for the detection and prognosis of several cancersJHU REF: C12506 Invention novelty: This invention has discovered high frequency mutations in the telomerase reverse transcriptase (TERT) promoter of certain cancers. Value Proposition: Early detection is usually critical for the successful treatment of cancer, therefore there is...

Published: 6/26/2025 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Chetan Bettegowda, Yuchen Jiao, Darell Bigner, Hai Yan, Zachary Reitman, Patrick Killela

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Hospital-to-Home-Health Transition Quality (H3TQ) Index

An express license for this technology is available via JHTV's online licensing portal.The Hospital-to-Home-Health Transition Quality (H3TQ) Index is a novel measure that identifies threats to patient safety in real time for older adults receiving skilled home healthcare (HH) services after hospital discharge. The H3TQ identifies organizational...

Published: 6/27/2025 | Inventor(s): Alicia Arbaje, Bruce Leff, Yea-Jen Hsu

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Category(s): Clinical and Disease Specializations > Geriatrics, Technology Classifications > Diagnostics > Precision Medicine Tools, Technology Classifications > Diagnostics

Total Neuropathy Score - clinical (TNSc)

An express license for this technology is available via JHTV's online licensing portal.The Total Neuropathy Score - Clinical (TNSc) is a composite measure of peripheral neuropathy for use by physicians. Arising from studies of chemotherapy-induced peripheral neuropathy (CIPN), the Total Neuropathy Score (TNS) was originally developed and validated...

Published: 6/26/2025 | Inventor(s): Vinay Chaudhry, David Cornblath

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Measurement Tool

Category(s): Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics

Total Neuropathy Score - Nurse

An express license for this technology is available via JHTV's online licensing portal.The Total Neuropathy Score - Nurse (TNSn) is a composite measure of peripheral neuropathy for use by trained non-physicians such as nurses or clinical research study coordinators.Arising from studies of chemotherapy-induced peripheral neuropathy (CIPN), the...

Published: 6/26/2025 | Inventor(s): Vinay Chaudhry, David Cornblath, Kathleen Griffith

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Screening Questionnaire

Category(s): Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics, Technology Classifications > Computers, Electronics & Software

Potential Energy Landscapes Reveal the Information-theoretic Nature of the Epigenome

Unmet NeedEpigenetics is the study of biochemical modifications carrying information independent of DNA sequence, which are heritable through cell division. To date, methylation landscapes have not yet been rigorously computed.Technology OverviewUsing principles from statistical physics and information theory, JHU inventors have derived epigenetic energy...

Published: 6/26/2025 | Inventor(s): Andrew Feinberg, John Goutsias, William Jenkinson, Elisabet Pujadas

Keywords(s): Assay, Clinical Diagnostics, In Vitro Diagnostics

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Methylated Markers for the Detection of Cervical Cancer

Unmet need:According to WHO, cervical cancer represents the fourth most common female cancer world-wide, with approximately 600,000 new cases as well as 300,000 deaths in 2020 alone (see WHO). Cervical cancer screening efforts aim to detect cancerous lesions in the cervix to enable earlier treatment. The main screening modalities include a Pap test...

Published: 6/27/2025 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Deyin Xing

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Cervical Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications, Technology Classifications > Diagnostics

ExoBLAze Assay: Efficient Quantification of EV Content Delivery

Value Proposition· Specific, FRET-based detection: only quantifies successful EV endosomal escape· Reliable and adaptable: assay works with variety of Evs, target cell types, and fluorescence detection methods· Genetic modification-free: does not require any genetic engineering of target cells· Ground-breaking solution: first proposed...

Published: 6/27/2025 | Inventor(s): Sarah Marquez, Zach Troyer, Kenneth Witwer

Keywords(s):

Category(s): Technology Classifications > Diagnostics

Combined mammography and quantitative ultrasound breast imaging system

Value Proposition· Comprehensive Examination – integrates conventional ultrasound, ultrasound tomography, photoacoustic imaging, and mammography.· Superior Accuracy – multiple imaging modalities deliver comprehensive and precise breast tissue analysis, reducing the risk of overdiagnosis and/or overtreatment. · Improved Early Detection...

Published: 6/27/2025 | Inventor(s): Emad Boctor, Yixuan Wu, Jeeun Kang, Keshuai Xu, Hyunwoo Song, Russell Taylor, Yuxin Chen, Yifan Yin, Joseph Stayman, Mohammad Salehizadeh

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Category(s): Technology Classifications, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health

Apparatus and Method for modular ultrasound and photoacoustic imaging and interactive guidance using a position-tracked modular imaging framework

Value Proposition· Wearable ultrasound system that is adaptable to different patient physiologies and ages.· Allows for longitudinal and non-invasive monitoring of internal organs of critical care patients.· Applicable across a broad range of organ systems and disease indications.· Simulation-aided interactive guidance simplifies...

Published: 6/27/2025 | Inventor(s): Jeeun Kang, Emad Boctor, Ananya Tandri

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Category(s): Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Imaging

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