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Apparatus and Method for modular ultrasound and photoacoustic imaging and interactive guidance using a position-tracked modular imaging framework

Value Proposition· Wearable ultrasound system that is adaptable to different patient physiologies and ages.· Allows for longitudinal and non-invasive monitoring of internal organs of critical care patients.· Applicable across a broad range of organ systems and disease indications.· Simulation-aided interactive guidance simplifies...

Published: 3/14/2025 | Inventor(s): Jeeun Kang, Emad Boctor, Ananya Tandri

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Category(s): Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Imaging

Non-contact Ultrasound Tomography Imaging System

Multifunctional 3D ultrasound imaging systemJHU Ref #: C17859Value Proposition:· Generation of high resolution 3D images for detection and diagnosis of diseases.· Overcomes previous required use of media (water) to image.· Media-less imaging ability allows for integration of other imaging techniques (MRI, PET, CT). Unmet Need· The...

Published: 3/14/2025 | Inventor(s): Jeeun Kang, Emad Boctor, Hyunwoo Song, Yixuan Wu

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Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Imaging

Method and System for the Early Detection of Acute Kidney Injury

Acute kidney injury (AKI) is a condition where the kidneys become unable to adequately filter the blood, causing toxic levels of waste to accumulate throughout the body. AKI is formally defined as a “>50% decrease in glomerular filtration rate (GFR) over a period of hours to days,” which leads to a decline in urine output over time. Measuring urine...

Published: 3/13/2025 | Inventor(s): Aaron Chang, Alexandra Sibole, Sriram Chadalavada, Madeleine Clegg, Patience Osei, Nevin Katz, Jonathan Magruder

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Disease Indication, Kidney Disorders, Measurement Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics

Compositions and Methods for Treating Diseases and Conditions Associated with Activation of the NLRP3 Inflammasome

Unmet NeedAutoinflammatory responses, your body’s innate defense mechanism against infections and stressors, can become overactive and cause chronic inflammation in various tissues and organs. Inflammatory diseases affect more than 200 million people worldwide and include pulmonary hypertension, scleroderma, rheumatoid arthritis, pulmonary fibrosis,...

Published: 3/14/2025 | Inventor(s): Roger Johns

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Epigenetic Changes in Sperm are Associated with Paternal and Child Quantitative Autistic Traits in an Autism-enriched Cohort

Value Proposition· Predictive Power: Provides an early non-invasive method to assess an offspring’s risk of autism before birth using paternal semen· Personalized Insight: Adapts risk prediction to individual genetic and epigenetic profiles· Environmental Sensitivity: Accounts for the impact of environmental factors on ASD risk· Platform-Agnostic:...

Published: 3/14/2025 | Inventor(s): Andrew Feinberg, Heather Volk, Jason Feinberg, Rose Schrott

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Category(s): Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology

Activating Mutations in GNAQ Sensitive to Antibiotic; Novel Molecular Pathway and Treatment Target for Capillary Malformations and Related Syndromes

Value Proposition: · Antibiotic treatment strategy for capillary malformations and Sturge-Weber Syndrome. · Selectively targets endothelial cells with the pathogenic GNAQ mutations using puromycin · Inhibits cell proliferation and reduces cell survival via activation of TRP6/NFAT signaling pathway · Compatible with various drug...

Published: 3/13/2025 | Inventor(s): Anne Comi, Jonathan Pevsner, Zhenhua Huang, Douglas Marchuk

Keywords(s): Biomarker, Disease Indication, Genetic Disorders, Mechanism-of-action Biomarker, Skin Disorders, Sturge-Weber Syndrome, Sturge-Weber Syndrome (SWS), Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Dermatology, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Dermatology > Sturge-Weber Syndrome

A DNA methylation and genotype specific biomarker of suicide attempt

Novel Biomarkers for Predicting Suicide RiskJHU REF: [C12394]Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting suicide risk. Value Proposition: Almost 30,000 people die of suicide each year in the United States, and 1 million people die worldwide. In the teenage population, it is the second leading cause of...

Published: 3/13/2025 | Inventor(s): Holly Wilcox, Zachary Kaminsky

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epigenetic, In Vitro Diagnostics, In Vitro Diagnostics (Old), Methylation, Prognostic Biomarker, Psychiatric Diseases, Suicidal Impulses, Suicide/Suicidal Impulses

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Clinical and Disease Specializations > Psychiatry > Suicidal Impulses

Diagnostic and therapeutic target for primary dysautonomia

Value Proposition:· Diagnostic target for broad primary dysautonomia screening.· Broadly applicable therapeutic target for symptom relief in primary and secondary dysautonomia patients.Technology DescriptionResearchers at Johns Hopkins have identified a potential diagnostic and therapeutic target for patients with primary dysautonomia....

Published: 3/14/2025 | Inventor(s): Malcolm Brock, Frank Bosmans

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Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities > Small Molecules

Treatment of fibrosis-associated pathologies through downstream TGF-β pathway inhibition

Value PropositionInhibits downstream signaling pathway of TGF-β signaling, reducing pleiotropic and off-target effects.Selectively targets tissue specific calpains, increasing efficacy as compared to current TGF-β signaling pathway inhibitory methods.Applicable to several disease models with specific focus on epithelial-to-mesenchymal transition pathologies....

Published: 3/13/2025 | Inventor(s): David Kim, Harry Dietz

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Fibrosis Disorders, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Automatic Radiological Reports and ASPECTS Calculation from Brain MRIs

Unmet NeedThe typical workflow for reporting quantitative data in Picture Archive and Communication System (PACS), is redundant, subjective, time-consuming, and hard to record. Automated radiological reports describing consistent lesion features such as location, contrast, and volumes, and related effects is a time-saver, particularly in acute conditions...

Published: 3/14/2025 | Inventor(s): Andreia Faria, Chin-Fu Liu

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Category(s): Technology Classifications > Medical Devices, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Imaging

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