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RASAL1 and PTEN Co-Alterations Predict Cancer Aggressiveness

Value Proposition· Improved Prognostic Accuracy: Dual detection of RASAL1 and PTEN alterations enables highly accurate identification of aggressive cancers and risk stratification. These biomarkers provide greater precision in identifying aggressive cancers compared to established markers, enabling better patient management. · Pan-Cancer...

Published: 1/22/2026 | Inventor(s): Michael Xing, Xiaopei Shen, Jie Tan

Keywords(s):

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Precision Medicine Tools, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Prognostics Biomarkers, Clinical and Disease Specializations > Oncology

Monoclonal Antibody for Cancer Metastasis

Unmet Need· It is projected that there will be about 1.9 million cancer cases, and 6 thousand cancer deaths within the US in the year 2023 (Siegel, 2021). mAb immunotherapy has been found to be less damaging and less invasive to rapidly dividing normal tissues when compared to current tumor therapy treatments such as surgery, radiation, and chemotherapy....

Published: 1/22/2026 | Inventor(s): Andrew Ewald, Matthew Dunworth, Shannon Radomski, Livia Casciola-Rosen, Antony Rosen

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Biomarkers, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

Quantum Plexcitonic Biosensing

Affinity biosensor for point-of-care diagnosticsJHU Ref #: C17711Value Proposition:· Highly sensitive biosensor that uses quantum plexcitons to detect a variety of biological analytes at extremely low concentrations· Greater specificity than industry leading surface plasmon resonance and quartz crystal microbalance technologies· Can...

Published: 1/22/2026 | Inventor(s): Ishan Barman, Peng Zheng

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers

In vivo and in vitro Role of Lactosylceramide Synthase (LCS) in Angiogenesis and LCS (B1, 4GalT-V) as a Bio-marker for Human Colon Cancer

Description: C10539: Use of Biomarker for Colon Cancer Diagnosis Value Proposition: ADVANTAGES • Colon cancer biomarker is directly included in panels of biomarkers for use in needle biopsies of colon tissue for early detection and diagnosis. • Colon cancer is the second largest mortality after cardiovascular disease. 90% of colorectal cancers...

Published: 1/22/2026 | Inventor(s): Subroto Chatterjee

Keywords(s): Antagonists/Inhibitors, Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Anti- TFAM Antibody Detection Assay Predicting Lethal Cardiovascular Events, damage accrual and malignancy in Lupus Patients

Value Proposition:· Specific biomarker for the detection of major adverse events, including thrombosis, in systemic lupus patients.· Serum samples are easily accessible for biomarker detection.· High specificity for thrombotic (clotting) event risk, malignancy and death.· Leverages common laboratory tests for detection for smooth...

Published: 1/22/2026 | Inventor(s): Felipe Andrade, Jose de Jesus Eduardo Gomez-Bañuelos

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity > Systemic Lupus Erythematosus, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Inflammation > Chronic Inflammatory Diseases, Clinical and Disease Specializations > Research Tools > Assays, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics

Compositions and Biomarkers for Human Cancer and Methods of Use

Novel biomarkers for the detection and prognosis of several cancersJHU REF: C12506 Invention novelty: This invention has discovered high frequency mutations in the telomerase reverse transcriptase (TERT) promoter of certain cancers. Value Proposition: Early detection is usually critical for the successful treatment of cancer, therefore there is...

Published: 1/22/2026 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Chetan Bettegowda, Yuchen Jiao, Darell Bigner, Hai Yan, Zachary Reitman, Patrick Killela

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Monoclonal Antibody to Treat Autoinflammation Associated with Chronic Diseases

Unmet NeedAutoinflammatory responses, your body’s innate defense mechanism against infections and stressors, can become overactive and cause chronic inflammation in various tissues and organs. Inflammatory diseases affect more than 200 million people worldwide and include pulmonary hypertension, scleroderma, rheumatoid arthritis, pulmonary fibrosis,...

Published: 1/22/2026 | Inventor(s): Roger Johns

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Autoantibody-based biomarker for systemic lupus erythematosus (SLE)

Unmet NeedPatients with systemic lupus erythematosus (SLE) have a range of symptoms across multiple organ systems. The primary diagnostic test for SLE is the antinuclear antibodies (ANA) test. However, there is disagreement between laboratories as to which ANA staining patterns are considered diagnostic. Additionally, as autoantibodies are present in...

Published: 1/22/2026 | Inventor(s): Felipe Andrade, Jose de Jesus Eduardo Gomez-Bañuelos

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity > Systemic Lupus Erythematosus, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Digital High Resolution Melt Microfluidic Platform and Assay for Assessing Locus-specific Molecular Heterogeneity of DNA Methylation

Value Proposition· Simple, low-cost microfluidic tool that evaluates DNA methylation using non-invasive liquid biopsy samples. · Allows for sensitive, specific evaluation of epigenetic biomarkers for early detection of cancer. · Includes software and algorithms for improved diagnostic interpretation of DNA methylation analyses. Unmet...

Published: 1/22/2026 | Inventor(s): Tza-Huei Wang, Christine O'Keefe, Thomas Pisanic

Keywords(s):

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Blood & Tissue Samples

Multiple-instance Learning on Antibody Repertoires for Detecting Specific Antibodies and Paratopes

Unmet NeedAntibodies are one of the most important tools in medicine. Although they have long been essential components of research experiments and diagnostic assays, their use as therapeutics is revolutionizing the treatment of many autoimmune and cancerous conditions. The antibody drug market is estimated at $126.7 billion (BCC Research) and the antibody...

Published: 1/22/2026 | Inventor(s): Jeremias Sulam, Jeffrey Ruffolo, Jeffrey Gray

Keywords(s):

Category(s): Technology Classifications > Diagnostics > Diagnostic Biomarkers

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