Search Results - technology+classifications+%3e+research+tools

524 Results

Sort By:

Accelerating Numerical Methods with AI-Based Surrogate Models

Value Proposition: Efficient modeling of dynamic phenomena with negligible error rates below 1% Reduced computational demand, not dependent on large datasets Utility across different domains and scalable to multiscale challenges Applicable to life sciences, material science, and engineering sectors Unmet Need: Accurate modeling of material...

Published: 6/27/2025 | Inventor(s): Somdatta Goswami, Wei Wang

Keywords(s):

Potential Energy Landscapes Reveal the Information-theoretic Nature of the Epigenome

Unmet NeedEpigenetics is the study of biochemical modifications carrying information independent of DNA sequence, which are heritable through cell division. To date, methylation landscapes have not yet been rigorously computed.Technology OverviewUsing principles from statistical physics and information theory, JHU inventors have derived epigenetic energy...

Published: 6/26/2025 | Inventor(s): Andrew Feinberg, John Goutsias, William Jenkinson, Elisabet Pujadas

Keywords(s): Assay, Clinical Diagnostics, In Vitro Diagnostics

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Efficient, Expansive, User-defined DNA Mutagenesis

C12015: Efficient, Expansive, User-defined DNA MutagenesisNovelty: This invention provides a leap forward in saturation mutagenesis called PFunkel. PFunkel is a next-generation Kunkel mutagenesis strategy that can, for the first time, efficiently and cheaply produce libraries containing user-defined mutations, including sequentially permuted genes....

Published: 6/26/2025 | Inventor(s): Elad Firnberg, Marc Ostermeier

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Know-how

Category(s): Technology Classifications > Research Tools

K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells

C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...

Published: 6/26/2025 | Inventor(s): Ben Ho Park

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Barcoding FRET-based Biosensors for Multiplexed and Standardized Measurement of Biomolecular Activities in Cells

Unmet Need: Biosensors are a widely used tool for tracking spatiotemporal dynamics of molecular activities. However, many biosensors are based on the Förster resonance energy transfer (FRET) between fluorescent proteins (FPs), and a major drawback has been their limited multiplexing capability due to the broad emission spectra of FPs and the availability...

Published: 6/27/2025 | Inventor(s): Chuan-Hsiang Huang, Jr-Ming Yang, Gabriel Au

Keywords(s):

Category(s): Technology Classifications > Research Tools

Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 6/26/2025 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Multiplexed 24-well Plate Stimulator

Value Proposition:· Device solely focused on stimulation· Increased relevance: stimulation increases physiological relevance of cellular models· Increased throughput: compatible with commercial 24-well plates to increase cost and time efficiency· Increased consistency: stimulation applied simultaneously across all wells Technology...

Published: 6/27/2025 | Inventor(s): Brian Lin, Peter Caron

Keywords(s):

Category(s): Technology Classifications > Research Tools, Technology Classifications > Computers, Electronics & Software

Col3a1G209S heterozygous mice

Unmet Need:Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder. Patients with vEDS present with thin, translucent skin, easy bruising, and a characteristic facial appearance. Most critically, they are at risk for spontaneous rupture of the major arteries, hollow organs, and gravid uterus. Preclinical investigation of...

Published: 6/27/2025 | Inventor(s): Harry Dietz, Caitlin Bowen, Juan Calderon Giadrosic, Mark Helmers

Keywords(s):

Category(s): Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

Col3a1G938D heterozygous mice

Published: 6/27/2025 | Inventor(s): Harry Dietz, Caitlin Bowen

Keywords(s):

Category(s): Clinical and Disease Specializations > Genetic Diseases, Technology Classifications, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

Loeys-Dietz Syndrome (LDS) Mouse Strains (Tgfbr2G357W/+ and Tgfbr1M318R/+)

Unmet Need:Loeys-Dietz Syndrome (LDS) is a rare genetic connective tissue disorder that is characterized by a high risk for aneurysm and dissection throughout the arterial tree and phenotypically resembles Marfan Syndrome. Marfan Syndrome and related disorders, such as LDS, have an incidence of 1 in 3000 to 5000 individuals (see UpToDate). LDS is specifically...

Published: 6/27/2025 | Inventor(s): Harry Dietz, Elena MacFarlane, David Loch

Keywords(s):

Category(s): Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

1 2 3 4 5 6 7 8 9 10 ...