Search Results - technology+classifications+%3e+research+tools

494 Results

Sort By:

A chemical agent for the selective production of DNA-protein crosslinks

Value Proposition· Demonstrated selectivity (40x) for production of DNA-protein cross link (DPC) formation as compared to DNA-DNA interstrand cross-link (ICL) formation.· Robust DPC formation shown in both nucleosome core particles and live human cell lines. · High yield of DNA-protein cross links with similar cellular toxicity as traditional...

Published: 4/24/2026 | Inventor(s): Marc Greenberg

Keywords(s):

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

Inner Ear-Specific Cre Mouse Model for Targeted Gene Deletion and Hearing Loss Research

JHU Ref #: C15757Value Proposition· Inner ear specificity: When bred with a mouse with a floxed gene of interest (GOI), the offspring will not express the GOI in the inner ear. · Applicable in multiple hearing models: Researchers can study effects of a GOI in the inner ear in both deaf and hearing mice.· Improved mouse line stability:...

Published: 4/24/2026 | Inventor(s): Dwight Bergles, Travis Babola

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Ear, Nose & Throat > Hearing Disorders, Technology Classifications > Research Tools

A Transgenic Mouse Line for Ablating Cells Positive for Opn4 Expression

TITLE A Transgenic Mouse Line for Ablating Cells Positive for Opn4 Expression CASE NUMBER: C17059 ABSTRACT Rod and cone photoreceptors detect light and relay this information through a multisynaptic pathway to the brain via retinal ganglion cells (RGCs). These retinal outputs support not only...

Published: 4/24/2026 | Inventor(s): Samer Hattar

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Transposon-Based Reporter Vector for High-Efficiency Regulatory DNA Sequence Screening

Value Proposition· Enhanced germline transmission - Tol2 transposon system provides superior integration efficiency compared to episomal DNA and alternative transposon systems· Streamlined cloning workflow - Gateway cloning system enables rapid insertion of test sequences without traditional restriction/ligation steps· Real-time...

Published: 4/23/2026 | Inventor(s): Elizabeth Grice, Shannon Fisher, Andrew McCallion

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

Low Cost Regulated Genetic Switch for Saccharomyces Cerevisiae

Low Cost Regulated Genetic Switch for Saccharomyces CerevisiaeJHU REF: C12857 Invention Novelty: This technology is a method of using a low cost regulated system for controlling gene expression in the yeast Saccharomyces cerevisiae. Value Proposition:Budding yeast Saccharomyces cerevisiae is one of the most important organisms in biotechnology. Currently...

Published: 4/23/2026 | Inventor(s): Jef Boeke, Shigehito Ikushima

Keywords(s): Cell Signaling, Discovery/Research Tools, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent, Yeast Model

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Yeast Model

Leucine-Rich Repeat Kinase 2 (LRRK2) cDNA Vectors Research Reagent

Studies have shown that mutations in the LRRK2 gene are the most common determinants of late-onset Parkinsons disease (PD) susceptibility. These cDNA vectors comprise wild type LRRK2 cDNA or mutated LRRK2 cDNA that can be expressed in cells to decipher the biochemical pathways and pathology of PD. Other advantages include:• Produced from human source...

Published: 4/23/2026 | Inventor(s): Ted Dawson

Keywords(s): Basic Research Biomarker, Cloning Reagents, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Nucleotide, Parkinson's Disease, Research Reagent

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Biomimetic Platform for Pulmonary Hypertension

Value Proposition· Biomimetic platform of human pulmonary arterioles that enables researchers and clinicians to better understand pulmonary hypertension.· Precisely engineered, tunable, functional, and anatomically accurate biomimetic human pulmonary microvasculature supports quantitative analysis of endothelial and smooth muscle cell...

Published: 4/24/2026 | Inventor(s): Lewis Romer, David Gracias, Jayson Pagaduan, Anil Bhatta, Xing Chen, Qianru Jin

Keywords(s): Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Lung Disorders, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Vascular Endothelial Growth Factor and Substrate Mechanics Regulate Vascular Tubulogenesis

Unmet Need:In recent decades, postnatal vasculogenesis has been considered to be an important mechanism for neovascularization via circulating endothelial progenitor cells (EPCs) derived from marrow. Since then, EPCs have been proposed as a potential tool for treating vascular disease, either through infusion to the site of vascularization or ex vivo...

Published: 4/23/2026 | Inventor(s): Donny Hanjaya-Putra, Sharon Gerecht

Keywords(s): Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

Incorporation of Lysine Tags as a Universal System for Controlling Protein Expression

Value Proposition· Precise and Tunable Protein Translation Control: Poly(A) track length can be varied from 1-12 AAA codons, providing precise and adjustable control over protein output.· Minimal Complexity: This technology offers predictable, graded control of protein expression using only a short DNA sequence insert—no external inducers,...

Published: 4/23/2026 | Inventor(s): Dorothy Green, Sergej Djuranovic

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Nucleotide, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

Multi-MHC Targeting Bispecific Antibody Platform for T-Cell Activation Against HIV-Infected Cells

Value Proposition· Superior target stability: Targets conserved HIV structural protein-derived peptide:MHC complexes that are highly expressed and stable, unlike rapidly-internalizing variable Env proteins used by current bispecifics· Comprehensive MHC coverage: First platform addressing HIV peptides across MHC-I, MHC-II, and HLA-E pathways,...

Published: 4/24/2026 | Inventor(s): Srona Sengupta, Robert Siliciano, Scheherazade Sadegh-Nasseri, Jacqueline Douglass

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > HIV, Technology Classifications, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools

1 2 3 4 5 6 7 8 9 10 ...