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Efficient, Expansive, User-defined DNA Mutagenesis

C12015: Efficient, Expansive, User-defined DNA MutagenesisNovelty: This invention provides a leap forward in saturation mutagenesis called PFunkel. PFunkel is a next-generation Kunkel mutagenesis strategy that can, for the first time, efficiently and cheaply produce libraries containing user-defined mutations, including sequentially permuted genes....

Published: 3/13/2025 | Inventor(s): Elad Firnberg, Marc Ostermeier

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Know-how

Category(s): Technology Classifications > Research Tools

K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells

C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...

Published: 3/13/2025 | Inventor(s): Ben Ho Park

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Barcoding FRET-based Biosensors for Multiplexed and Standardized Measurement of Biomolecular Activities in Cells

Unmet Need: Biosensors are a widely used tool for tracking spatiotemporal dynamics of molecular activities. However, many biosensors are based on the Förster resonance energy transfer (FRET) between fluorescent proteins (FPs), and a major drawback has been their limited multiplexing capability due to the broad emission spectra of FPs and the availability...

Published: 3/14/2025 | Inventor(s): Chuan-Hsiang Huang, Jr-Ming Yang, Gabriel Au

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Category(s): Technology Classifications > Research Tools

Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 3/13/2025 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Multiplexed 24-well Plate Stimulator

Value Proposition:· Device solely focused on stimulation· Increased relevance: stimulation increases physiological relevance of cellular models· Increased throughput: compatible with commercial 24-well plates to increase cost and time efficiency· Increased consistency: stimulation applied simultaneously across all wells Technology...

Published: 3/14/2025 | Inventor(s): Brian Lin, Peter Caron

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Category(s): Technology Classifications > Research Tools, Technology Classifications > Computers, Electronics & Software

Col3a1G209S heterozygous mice

Unmet Need:Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder. Patients with vEDS present with thin, translucent skin, easy bruising, and a characteristic facial appearance. Most critically, they are at risk for spontaneous rupture of the major arteries, hollow organs, and gravid uterus. Preclinical investigation of...

Published: 3/14/2025 | Inventor(s): Harry Dietz, Caitlin Bowen, Juan Calderon Giadrosic, Mark Helmers

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Category(s): Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

Col3a1G938D heterozygous mice

Published: 3/14/2025 | Inventor(s): Harry Dietz, Caitlin Bowen

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Category(s): Clinical and Disease Specializations > Genetic Diseases, Technology Classifications, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

Loeys-Dietz Syndrome (LDS) Mouse Strains (Tgfbr2G357W/+ and Tgfbr1M318R/+)

Unmet Need:Loeys-Dietz Syndrome (LDS) is a rare genetic connective tissue disorder that is characterized by a high risk for aneurysm and dissection throughout the arterial tree and phenotypically resembles Marfan Syndrome. Marfan Syndrome and related disorders, such as LDS, have an incidence of 1 in 3000 to 5000 individuals (see UpToDate). LDS is specifically...

Published: 3/14/2025 | Inventor(s): Harry Dietz, Elena MacFarlane, David Loch

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Category(s): Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

Identification of RNF43 Mutations in Pancreatic Cysts

Unmet Need· One third of diagnoses for surgical resection of pancreatic cysts are incorrect, leading to unnecessary surgery, medical risk, and high costs (Hammel, 2002). The current standard of care for determining pancreatic cyst type is based solely on symptom progression and imaging criteria, and histopathological analysis is only available...

Published: 3/13/2025 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Jian Wu, Anirban Maitra, Ralph Hruban, Marco Dal Molin

Keywords(s): Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, Nucleotide, Pancreatic Cancer, Research Reagent, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers

A method to enhance delivery and editing efficiencies of CRISPR-Cas9

Value Proposition· Mechanical tuning of stiffness and viscoelasticity results in higher editing efficiency and requires less transfection reagents compared to traditional plasmid-based CRISPR-Cas9 methods. · Enhanced cell-substrate interactions between the cells and gels leads to greater uptake of nanoparticles, quicker onset of gene editing,...

Published: 3/14/2025 | Inventor(s): Luo Gu, Joon Eoh

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Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Research Tools

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