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Unmet NeedAccording to the CDC, approximately 5.8-million individuals aged 65+ in the United States were living with Alzheimer’s disease in 2020 (see CDC). Alzheimer’s disease leads to memory impairment that progressively affects the ability of individuals to conduct daily tasks and worsens with time. Currently, the diagnosis of Alzheimer’s disease...

Published: 3/12/2026 | Inventor(s): Esther Oh, Stina Tucker, David Borchelt, Juan Troncoso

Keywords(s): Alzheimer's Disease, Antibodies, Biologics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Neurodegeneration, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration

Transposon-Based Reporter Vector for High-Efficiency Regulatory DNA Sequence Screening

Value Proposition· Enhanced germline transmission - Tol2 transposon system provides superior integration efficiency compared to episomal DNA and alternative transposon systems· Streamlined cloning workflow - Gateway cloning system enables rapid insertion of test sequences without traditional restriction/ligation steps· Real-time...

Published: 3/12/2026 | Inventor(s): Elizabeth Grice, Shannon Fisher, Andrew McCallion

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

Low Cost Regulated Genetic Switch for Saccharomyces Cerevisiae

Low Cost Regulated Genetic Switch for Saccharomyces CerevisiaeJHU REF: C12857 Invention Novelty: This technology is a method of using a low cost regulated system for controlling gene expression in the yeast Saccharomyces cerevisiae. Value Proposition:Budding yeast Saccharomyces cerevisiae is one of the most important organisms in biotechnology. Currently...

Published: 3/12/2026 | Inventor(s): Jef Boeke, Shigehito Ikushima

Keywords(s): Cell Signaling, Discovery/Research Tools, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent, Yeast Model

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Yeast Model

Human LRRK2 cDNA

Studies have shown that mutations in the LRRK2 gene are the most common determinants of late-onset Parkinsons disease (PD) susceptibility. These cDNA vectors comprise wild type LRRK2 cDNA or mutated LRRK2 cDNA that can be expressed in cells to decipher the biochemical pathways and pathology of PD. Other advantages include:• Produced from human source...

Published: 3/12/2026 | Inventor(s): Ted Dawson

Keywords(s): Basic Research Biomarker, Cloning Reagents, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Nucleotide, Parkinson's Disease, Research Reagent

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Biomimetic Platforms to Model Vascular Pathophysiology, Diagnostics, and Therapy

Value Proposition· Biomimetic platform of human pulmonary arterioles that enables researchers and clinicians to better understand pulmonary hypertension.· Precisely engineered, tunable, functional, and anatomically accurate biomimetic human pulmonary microvasculature supports quantitative analysis of endothelial and smooth muscle cell...

Published: 3/12/2026 | Inventor(s): Lewis Romer, David Gracias, Jayson Pagaduan, Anil Bhatta, Xing Chen, Qianru Jin

Keywords(s): Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Lung Disorders, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Vascular Endothelial Growth Factor and Substrate Mechanics Regulate Vascular Tubulogenesis

Unmet Need:In recent decades, postnatal vasculogenesis has been considered to be an important mechanism for neovascularization via circulating endothelial progenitor cells (EPCs) derived from marrow. Since then, EPCs have been proposed as a potential tool for treating vascular disease, either through infusion to the site of vascularization or ex vivo...

Published: 3/12/2026 | Inventor(s): Donny Hanjaya-Putra, Sharon Gerecht

Keywords(s): Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

Incorporation of Lysine Tags as a Universal System for Controlling Protein Expression

Value Proposition· Precise and Tunable Protein Translation Control: Poly(A) track length can be varied from 1-12 AAA codons, providing precise and adjustable control over protein output.· Minimal Complexity: This technology offers predictable, graded control of protein expression using only a short DNA sequence insert—no external inducers,...

Published: 3/12/2026 | Inventor(s): Dorothy Green, Sergej Djuranovic

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Nucleotide, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

Multi-MHC Targeting Bispecific Antibody Platform for T-Cell Activation Against HIV-Infected Cells

Value Proposition· Superior target stability: Targets conserved HIV structural protein-derived peptide:MHC complexes that are highly expressed and stable, unlike rapidly-internalizing variable Env proteins used by current bispecifics· Comprehensive MHC coverage: First platform addressing HIV peptides across MHC-I, MHC-II, and HLA-E pathways,...

Published: 3/13/2026 | Inventor(s): Srona Sengupta, Robert Siliciano, Scheherazade Sadegh-Nasseri, Jacqueline Douglass

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > HIV, Technology Classifications, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools

NK1-Cre mice

Invention novelty: Project neurons in the spinal cord play essential role in transmitting and modulating pain and itch signals from the periphery. NK1 is the receptor of the major pain and itch neurotransmitter peptide substance P. NK1 is expressed in the project neurons in the dorsal horn of the spinal cord. Dysfunction of these neurons often leads...

Published: 3/12/2026 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Ligation in situ Hybridization for highly multiplexed RNA analysis of fixed tissue specimens

Unmet Need: Formalin fixed and paraffin embedded (FFPE) tissues are the most common form of patient specimens analyzed by pathologists. This standard practice of preserving clinical samples, however, dramatically damages the RNA content of these valuable specimens. RNA molecules provide important information about which genes are being expressed in...

Published: 3/12/2026 | Inventor(s): Harry Larman, Joel Credle

Keywords(s): Discovery/Research Tools, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools

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