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Composition of Media with Defined Fluid Viscosity for Enhancing Intracellular Delivery of Nanoparticles and Viral Vectors, and Methods of Use
Unmet Need· Production of gene therapies, cell therapies, and recombinant proteins are largely dependent on efficient transfection using viral vectors or nanoparticle vehicles to deliver genetic cargo. However, although numerous transfection reagents have been developed, many strategies still suffer from low efficiency in particular cell-lines...
Published: 3/14/2025
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Inventor(s):
Hai-Quan Mao
,
Yining Zhu
,
Jingyao Ma
,
Sean Sun
,
Zhuoxu Ge
,
Qin Ni
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Buffers & Media Solutions
,
Technology Classifications > Research Tools > Vectors & Plasmids
,
Technology Classifications > Research Tools > Viruses
,
Technology Classifications > Research Tools > Nucleic Acids
Kinetically controlled methods to prepare concentrated shelf-stable nucleic acid transfection vehicles
Value Proposition:· Technology creates particles optimally size for use as vehicles for cell transfection.· The reagents and processes for particle creation are kinetically controlled and reproducible.· Cationic particles created using these methods can carry larger payloads than current vehicles.· Reagents and nucleic acid-loaded...
Published: 3/14/2025
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Inventor(s):
Hai-Quan Mao
,
Yizong Hu
,
Jinghan Lin
Keywords(s):
Category(s):
Technology Classifications > Engineering Tech > Bioreactors
,
Technology Classifications > Engineering Tech > Materials
,
Technology Classifications > Industrial Tech > Bioreactors
,
Technology Classifications > Research Tools > Buffers & Media Solutions
,
Technology Classifications > Research Tools > Nucleic Acids
,
Technology Classifications > Research Tools > Peptides
,
Technology Classifications > Research Tools > Vectors & Plasmids
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Therapeutic Modalities > Gene Therapies
,
Technology Classifications > Therapeutic Modalities > Cell Therapies
,
Technology Classifications > Therapeutic Modalities > Peptides
,
Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms
Multicolor SYNGAP1 Alternative Splice Reporters
Value Proposition· High sensitivity: detection of specific splicing events · High throughput: can assess multiple splicing scenarios due to tri-chromatic and tetra-chromatic reporter plasmids · Improved SYNGAP1 treatment research· Reduced time to assess candidate treatments Technology DescriptionResearchers at Johns Hopkins...
Published: 3/14/2025
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Inventor(s):
Ingie Hong
,
Richard Huganir
,
Yoichi Araki
,
Richard Johnson
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Vectors & Plasmids
,
Clinical and Disease Specializations > Psychiatry > Autism Spectrum Disorder
,
Clinical and Disease Specializations > Psychiatry > Schizophrenia
Targeted capture of custom nucleotide sequences for single-cell sequencing
Value Proposition· Implementation only requires simple modification of current capture beads.· Allows for targeting of custom sequences of interest that may be cell-type specific or expressed at low levels.· Targets RNA molecules without polyA tails.· Inexpensive modification to existing commercial methods. Technology DescriptionResearchers...
Published: 3/14/2025
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Inventor(s):
Jonathan Ling
,
Katherine Irwin
,
Irika Sinha
,
Philip Wong
,
Linda Orzolek
,
Tyler Creamer
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Nucleic Acids
,
Technology Classifications > Research Tools > Vectors & Plasmids
,
Technology Classifications > Research Tools > Assays
SYNGAP1 splice-switching antisense oligonucleotide as therapy for human cognitive disorders
Unmet Need: SYNGAP1-related Intellectual Disability (SRID, MRD5) is a severe neurodevelopmental disorder (NDD) characterized by encephalopathy, intellectual disability (ID), autism spectrum disorder (ASD), and epilepsy and accounts for 0.5-1% of all NDDs and ~1% of the ~200 million ID cases worldwide (SYNGAP Research Fund, 2020). Supportive management...
Published: 3/14/2025
|
Inventor(s):
Richard Huganir
,
Yoichi Araki
,
Ingie Hong
,
Richard Johnson
,
Yinuo Han
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Vectors & Plasmids
Compositions of Kinetic Nanoparticles containing Nucleic Acids, Polycations, and Lipids with Defined Sizes, and Methods of Producing the Same
Value Proposition:· Scalable, efficient, and tunable nanoparticle creation technique that can deliver a variety of payloads· Polymer-lipid nanoparticles are biodegradable and are being tested for immunogenicity· Can be used for in vivo gene therapy delivery as well as in vitro cell transfection and research applications Technology...
Published: 3/14/2025
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Inventor(s):
Hai-Quan Mao
,
Stephany Tzeng
,
Jordan Green
,
Yizong Hu
,
Sashank Reddy
,
Leonardo Cheng
Keywords(s):
Category(s):
Clinical and Disease Specializations > Immuno-Oncology
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Engineering Tech > Materials
,
Technology Classifications > Research Tools > Nucleic Acids
,
Technology Classifications > Research Tools > Peptides
,
Technology Classifications > Research Tools > Vectors & Plasmids
,
Technology Classifications > Therapeutic Modalities > Gene Therapies
,
Technology Classifications > Therapeutic Modalities > Peptides
,
Technology Classifications > Therapeutic Modalities > Proteins
,
Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms
Method for using alternative splicing to control specificity of gene therapy
Unmet NeedViral-based gene therapy holds tremendous promise for the treatment of human diseases. Using genetically engineered carriers called vectors to deliver genes into cells, gene therapy can help replace a mutated gene with a healthy copy or even introduce a new gene into the body to fight a disease. However, an important concern when designing...
Published: 3/14/2025
|
Inventor(s):
Jonathan Ling
,
Seth Blackshaw
Keywords(s):
Drug Delivery Mechanism
,
Gene Therapy
,
Single
,
Therapeutic Matter
,
Therapeutics
,
Therapy Type
Category(s):
Technology Classifications > Therapeutic Modalities > Gene Therapies
,
Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms
,
Technology Classifications > Research Tools > Vectors & Plasmids
Induced Pluripotent Stem Cell Lines (BC1 and C7) and Plasmids (pEB-C5, pEB-Tg)
The Material consists of two induced pluripotent stem (iPS) cell lines derived from human bone marrow and cord blood.and plasmids used to create these virus-free and integration-free human iPS cell lines.
Published: 3/13/2025
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Inventor(s):
Linzhao Cheng
Keywords(s):
Basic Research Biomarker
,
Cell Model
,
Cloning Reagents
,
Discovery/Research Tools
,
In Vitro Research Tool
,
Plasmid
,
Research Reagent
,
Stem Cells
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Stem Cells
,
Technology Classifications > Research Tools > Vectors & Plasmids
,
Technology Classifications > Research Tools
Single Vector Genome Editing with CRISPR/Cas and BacMam
Unmet NeedTargeted, site-specific genome editing is an important scientific tool with broad applications in basic science, the pharmaceutical industry, and translational medicine. It enables the addition of florescent or other types of gene tags for purification, visualization, or tracking. Genome editing can also introduce novel functions for endogenous...
Published: 3/14/2025
|
Inventor(s):
Chulan Kwon
,
Renjun Zhu
,
Amir Saberi
Keywords(s):
Basic Research Biomarker
,
Cloning Reagents
,
Discovery/Research Tools
,
Other Virus
,
Plasmid
,
Research Reagent
,
Translational Research Biomarker
,
Viruses
Category(s):
Technology Classifications > Research Tools > Vectors & Plasmids
,
Technology Classifications > Research Tools > Viruses
Compositionally Defined Plasmid DNA/Polycation Nanoparticles and Methods for Making the Same
Unmet NeedGene therapy can be a cure-all for genetic disorders, and can be a promising therapy for diseases such as cancer, neurodegenerative diseases, neurological disorders, heart disease or diabetes. The success of gene therapy is dependent on the safety, efficacy, and specificity of the treatment. The delivery vehicle, also known as a vector, is...
Published: 3/14/2025
|
Inventor(s):
Hai-Quan Mao
,
Yizong Hu
,
Martin Pomper
,
Heng-wen Liu
,
Il Minn
,
Christopher Ullman
,
Christine Carrington
Keywords(s):
Drug Delivery Vehicle
,
Drug Delivery Vehicle Synthesis Method
,
Nanoparticles
,
Therapeutic Matter
,
Therapeutics
Category(s):
Technology Classifications > Research Tools > Vectors & Plasmids
,
Technology Classifications > Therapeutic Modalities > Gene Therapies
,
Clinical and Disease Specializations > Oncology
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