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Unmet NeedAccording to the CDC, approximately 5.8-million individuals aged 65+ in the United States were living with Alzheimer’s disease in 2020 (see CDC). Alzheimer’s disease leads to memory impairment that progressively affects the ability of individuals to conduct daily tasks and worsens with time. Currently, the diagnosis of Alzheimer’s disease...

Published: 3/12/2026 | Inventor(s): Esther Oh, Stina Tucker, David Borchelt, Juan Troncoso

Keywords(s): Alzheimer's Disease, Antibodies, Biologics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Neurodegeneration, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration

Dendrimer Conjugated Glutamine Antagonists for Targeted Brain and Tumor Delivery

Value Proposition· Deliver glutamine antagonists to the CNS without GI and systemic toxicity assiated with free DON.· High specificity for activated microglia and tumor-associated macrophages, providing therapeutic precision across neuroinflammatory and oncologic indications. · Broad applicability across CNS, cancer, and immune disorders,...

Published: 3/13/2026 | Inventor(s): Barbara Slusher, Rana Rais, Kannan Rangaramanujam, Anjali Sharma, Pavel Majer, Benjamin Bell, Lukas Tenora, Katerina Novotna, Martin Hadzima, Martin Kaiser, Tomas Tichy, Takashi Tsukamoto, Run-Duo Gao, Xiaolei Zhu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules

L2 Lipopeptide Vaccine for Prevention of Human Papillomavirus Infection

C10218: L2 Lipopeptide Vaccine for Prevention of Human Papillomavirus Infection Value Proposition: • A broadly protective vaccine against HPV. • Can be delivered without needles. • Can be chemically synthesized at low cost. Technical Details: Human papillomavirus (HPV) infections are the most common sexually transmitted infection in the...

Published: 3/12/2026 | Inventor(s): Hannah Alphs-Jackson, Ratish Gambhira, Richard Roden

Keywords(s): Biologics, Cancers, Disease Indication, Therapeutic Matter, Therapeutic Substance, Therapeutics, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities

Co-assembling Peptide Hydrogels

The compositions and methods disclosed herein pertain to the manufacture and use of hydrogels. The disclosed compositions and methods pertain to hydrogels capable of induction by a variety of methodologies, such as by pH, salt and/or mixing. Such hydrogels are capable of self- or co-assembly and while doing so, may entrap a variety of bioactive agents...

Published: 3/12/2026 | Inventor(s): Yihua Yu, Sivakumar Ramachandran, Peter Flynn, Yiider Tseng

Keywords(s): Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

A peptide that forms pores in membranes at acidic pH for the delivery of macromolecules through the plasma membrane or endosomes, or the lysis of cancer cells.

Unmet Need There are significant roadblocks to the routine delivery of macromolecules such as proteins, peptides, imaging agents, polysaccharides and more to the cytosol of mammalian cells. While most macromolecules are easily directed to existing cellular uptake mechanisms, they are often trapped in endosomal pathways leading to lysosomal degradation...

Published: 3/12/2026 | Inventor(s): Kalina Hristova, Gregory Wiedman, William Wimley, Sarah Kim

Keywords(s): Biologics, Drug Delivery Vehicle, Peptide, Peptides/Prodrugs, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities

Intra-operative Orthognathic Biomechanical Simulation

Value Proposition· Real-Time Operation Adjustments: The system provides live 3D positioning updates of the donor and recipient anatomies, allowing for instant feedback for surgeons. · Mastication Simulation: The technology spontaneously identifies ideal positioning of the donor face to allow for optimal recipient mastication post-op.· Mid-Surgery...

Published: 3/12/2026 | Inventor(s): Ryan Murphy, Mehran Armand, Peter Liacouras, Gerald Grant, Chad Gordon, Ehsan Basafa

Keywords(s): Integrated Imaging System, Interventional and Surgical Systems, Surgical Navigation

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Surgery, Applied Physics Laboratory > Applied Physics Laboratory, Clinical and Disease Specializations > Transplantation, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Plastic Surgery, Technology Classifications, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Traumatic Injury > Craniomaxillofacial Trauma

Targeting of Myeloid-Derived Suppressor Cells (MDSCs) for Cancer Treatment

Value Proposition· Addresses key resistance mechanism: targets MDSCs, a central driver of resistance to immune checkpoint inhibitors in metastatic and poorly immunogenic cancers· Synergistic combination strategy: Combines epigenetic modulators (HDAC and DNA methyltransferase inhibitors) with anti-PD-1 and anti-CTLA-4 antibodies to restore...

Published: 3/12/2026 | Inventor(s): KiBem Kim, Bert Vogelstein, Kenneth Kinzler, Shibin Zhou

Keywords(s): Antagonists/Inhibitors, Antibodies, Biologics, Cancers, Combination, Disease Indication, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Targeted Therapy/Immunotherapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

PSMA-targeted Nanoparticles for Therapy of Prostate Cancer

PSMA-targeting nanoparticle for prostate cancer therapyJHU Ref #: C10180Value Proposition:· Engineered nanoparticle system with potent urea-based PSMA inhibitor· Drug loaded nanoparticle· Specific and selective tumor cytotoxicity Unmet NeedProstate cancer affects millions of men globally and is a leading cause of cancer death in...

Published: 3/12/2026 | Inventor(s): Martin Pomper, Ronnie Mease, Sachin Chandran, Sangeeta Ray, Samuel Denmeade

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Prostate Cancer, Single, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Prostate Cancer

Repurposing Perampanel to treat SYNGAP1-related disorders

Value Proposition:· First Targeted Pharmacologic Therapy for SYNGAP1 (MRD5): Introduces the first mechanism-driven treatment strategy for SYNGAP1-related neurodevelopmental disorders, addressing sleep and behavioral dysfunction at the synaptic circuitry level.· Repurposing of an FDA Approved Drug: Utilizes Perampanel (PMP), an already FDA-approved...

Published: 3/13/2026 | Inventor(s): Shilpa Kadam

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Technology Classifications > Therapeutic Modalities

System for Enhancing Stem Cell Growth & Development Using Fluid Viscosity to Support Tissue Regeneration and Engraftment

Value Proposition· Preserve bone-forming potential (osteogenic phenotype) in soft tissue environments· Reduces immune rejection by promoting an immunosuppressive macrophage response· Enables preconditioning of stem cells for enhanced engraftment success· Applicable to a wide range of regenerative medicine and tissue engineering therapies· Introduces...

Published: 3/13/2026 | Inventor(s): Konstantinos Konstantopoulos, Alice Amitrano, Qinling Yuan, Bhawana Agarwal, Luo Gu, Jude Phillip, Yoseph Dance, Yi Zuo

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Stem Cells

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