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PSMA-targeted Nanoparticles for Therapy of Prostate Cancer

PSMA-targeting nanoparticle for prostate cancer therapyJHU Ref #: C10180Value Proposition:· Engineered nanoparticle system with potent urea-based PSMA inhibitor· Drug loaded nanoparticle· Specific and selective tumor cytotoxicity Unmet NeedProstate cancer affects millions of men globally and is a leading cause of cancer death in...

Published: 1/22/2026 | Inventor(s): Martin Pomper, Ronnie Mease, Sachin Chandran, Sangeeta Ray, Samuel Denmeade

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Prostate Cancer, Single, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Prostate Cancer

Repurposing Perampanel to treat SYNGAP1-related disorders

Value Proposition:· First Targeted Pharmacologic Therapy for SYNGAP1 (MRD5): Introduces the first mechanism-driven treatment strategy for SYNGAP1-related neurodevelopmental disorders, addressing sleep and behavioral dysfunction at the synaptic circuitry level.· Repurposing of an FDA Approved Drug: Utilizes Perampanel (PMP), an already FDA-approved...

Published: 1/22/2026 | Inventor(s): Shilpa Kadam

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Technology Classifications > Therapeutic Modalities

System for Enhancing Stem Cell Growth & Development Using Fluid Viscosity to Support Tissue Regeneration and Engraftment

Value Proposition· Preserve bone-forming potential (osteogenic phenotype) in soft tissue environments· Reduces immune rejection by promoting an immunosuppressive macrophage response· Enables preconditioning of stem cells for enhanced engraftment success· Applicable to a wide range of regenerative medicine and tissue engineering therapies· Introduces...

Published: 1/22/2026 | Inventor(s): Konstantinos Konstantopoulos, Alice Amitrano, Qinling Yuan, Bhawana Agarwal, Luo Gu, Jude Phillip, Yoseph Dance, Yi Zuo

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Stem Cells

Breathable Nanomedicine: Inhalable Angiotensin Blockers for Treating COVID-19 and Respiratory Infections

Value Proposition· Provides targeted pulmonary delivery with superior lung pharmacokinetics· Offers mutation-resistant therapeutic action, unlike current vaccines· Reduces risk of progression to severe lung disease in newly diagnosed patients· Applicable to a wide range of respiratory infections and ARDS-related conditions· Enhances...

Published: 1/22/2026 | Inventor(s): Jung Soo Suk, Daiqin Chen, Joe DiCostanzo, Axel Lehrer, Oreola Donini

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Clinical and Disease Specializations > Infectious Diseases > Respiratory Infections, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Respiratory Diseases > Acute Respiratory Distress Syndrome, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Targets

Targeted chemo-immunotherapy delivery

Value PropositionEnhanced effect of immunotherapyTreatment for recurrent or metastatic diseaseImproved glioma treatment Unmet NeedImmunotherapy represents a new paradigm in cancer treatment. Molecules that effectively reverse the immune suppressing nature of cancer have the potential to enhance the body’s ability to work systemically combat cancer (Pardoll,...

Published: 1/22/2026 | Inventor(s): Dimitrios Mathios, Betty Tyler, Drew Pardoll, Henry Brem, Michael Lim

Keywords(s): Antagonists/Inhibitors, Cancers, Chemotherapy/Immunotherapy, Combination, Disease Indication, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities

Mimetic peptides derived from collagen type IV for the treatment of angiogenesis-dependent diseases

C11348: Novel Anti-Angiogenic Collagen Derived Mimetic PeptidesNovelty:modified peptides from collagen IV derived parent peptide Pentastatin-1Value Proposition:The invention describes the synthesis of novel anti-angiogenic by substituting particular amino acids of the peptide Pentastatin-1 derived from collagen IV. Other advantages include:• Ability...

Published: 1/22/2026 | Inventor(s): Niranjan Pandey, Elena Rosca, Corban Rivera, Jacob Koskimaki, Amir Tamiz, Aleksander Popel

Keywords(s): Biologics, Cancers, Disease Indication, Peptide, Protein, Single, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

Nanoparticles for Topical Drug Delivery and Treatment of Hair Growth Conditions

Nanoparticles for Topical Drug Delivery and Treatment of Hair Growth ConditionsJHU REF: [C11686]Invention novelty: This invention is a nanoparticle for topical drug delivery targeting hair growth conditions. The particle may be an effective drug delivery tool for conditions such as hirsutism (excess hair) or alopecia (hair loss).Value PropositionThis...

Published: 1/22/2026 | Inventor(s): Sewon Kang, Amanda Nelson, Joshua Wolfe, Jennifer Sample, Xiomara Calderon-Colon, Jason Benkoski, Mellisa Theodore, Julia Patrone, Marcia Patchan, Luis Garza

Keywords(s): Drug Delivery Vehicle, Lipid, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Anti-Fungal Drug Analogs to Treat Cancer by Preventing Angiogenesis and Hedgehog Pathway Activity

Value Proposition· Itraconazole is in clinical trials for cancer treatment as it is known to have antiangiogenic activity and anti-Hedgehog pathway activity, but its use has been limited by its potent inhibition of the drug metabolizing enzyme CYP3A4· The designed analog for itraconazole has greater antiangiogenic potency without CYP3A4 inhibition...

Published: 1/22/2026 | Inventor(s): Jun Liu, Wei Shi, Kalyan Kumar Pasunooti, Wukun Liu, Ruojing Li, Sarah Head, Yingjun Li

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Eye Disorders, Macular Degeneration, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration

Polymeric particles for sustained delivery of multimodal peptide therapeutics

Value Proposition· Stability: polymeric nanoparticle encapsulation increases and sustains peptide residence time, for increased accumulation in tissue vasculature and maximize treatment effects· Safety: use of nanoparticles reduces toxicity by confining peptide delivery to site of administration· Flexible formulation approaches: system's...

Published: 1/22/2026 | Inventor(s): Jordan Green, Aleksander Popel, Joel Sunshine, Ron Shmueli, Stephany Tzeng, Kristen Kozielski

Keywords(s): Biologics, Drug Delivery Vehicle, Nucleic Acid, Peptide, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities

Cationic Polymers with Biphasic Biodegradation

Value Proposition· Delivery Efficacy: Demonstrates more effective gene delivery to cancer associated fibroblasts (CAFs) or human primary fibroblasts than industry gold-standards such as Lipofectamine 2000 and polyethylenimine (PEI).· Cargo Compatibility: Enables encapsulation and delivery of a wide range of cargos including, DNA, RNA,...

Published: 1/22/2026 | Inventor(s): Stephany Tzeng, Ron Shmueli, Nupura Bhise, Joel Sunshine, Jordan Green

Keywords(s): Drug Delivery Vehicle, Polymers, Therapeutic Matter, Therapeutics

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