Search Results - tissue+engineering%2fregenerative+devices

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Hollow, Perfusable Small-Diameter Tissue Engineered Vascular Grafts

Unmet NeedCardiovascular disease, often called “heart disease,” refers to conditions that involve narrowed or blocked blood vessels that can lead to a heart attack. Approximately 43% of all cardiovascular disease cases involve coronary artery disease (CAD) and require coronary artery bypass surgery. Implantation of vascular grafts is the most common...

Published: 9/26/2024 | Inventor(s): Sharon Gerecht, Morgan Elliott, Brian Ginn, Sebastian Barreto Ortiz, Hai-Quan Mao

Keywords(s): Cardiovascular Diseases, Coronary Heart Disease, Disease Indication, Implanted Device, Implants, Peripheral Artery Disease, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Vascular Diseases

Category(s): Clinical and Disease Specializations, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Cardiovascular > Coronary Heart Disease, Clinical and Disease Specializations > Cardiovascular > Peripheral Artery Disease, Clinical and Disease Specializations > Cardiovascular > Vascular Diseases

Multiphase Transitioning Peptride Hydrogel for Use in Vascular Anastamosis

Unmet NeedThe formation of vascular anastomosis, the joining of two blood vessels, is a fairly common procedure utilized by many surgeons. All vascular bypass operations and solid organ transplants require anastomoses. However, as the vessels being anastomosed become smaller or less firm, surgeons have exponentially increasing rates of failure. In...

Published: 9/26/2024 | Inventor(s): Daniel Smith, Johanna Grahammer, Joel Schneider, Gerald Brandacher, Gabriel Brat

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

Retinal Implantation Device

Unmet NeedMillions of people around the world suffer from retinal degenerative diseases at varying degrees of vision loss. Common to all retinal degenerative diseases is the damage to photoreceptor cells of the retina, which malfunction and disappear. Current treatments can begin with trying to “rescue” remaining photoreceptors. Unfortunately this strategy...

Published: 9/26/2024 | Inventor(s): Mandeep Singh, Kevin Wolfe, Jin Kang, Kathleen Perrino, Andrea Timm

Keywords(s): Disease Indication, Eye Disorders, Implanted Device, Implants, Macular Degeneration, Retinal Degeneration, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Retinal Degeneration, Technology Classifications > Medical Devices > Regenerative Medicine

Extracellular Matrix Scaffolds for Combination Immunotherapy

Unmet NeedThe critically important goal of regenerative medicine is the stimulation of in vivo wound healing and the production of functional tissue to repair or replace tissues loss to injury or disease. Extracellular matrix (ECM) materials are acellular tissue derived scaffolds commonly used in tissue regeneration following malignant or benign tumor...

Published: 9/26/2024 | Inventor(s): Jennifer Elisseeff, Matthew Wolf

Keywords(s): Cancers, Cell Therapy/Immunotherapy, Combination, Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutic Matter, Therapeutics, Therapy Type, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Medical Devices > Regenerative Medicine

Self-organized Vascular Networks from Human Pluripotent Stem Cells in a Synthetic Matrix

Unmet NeedTissue regeneration is a large part of a huge market for redeveloping tissues that have been damaged or have lost functionality. The success of tissue regenerative therapies is dependent on functional and multicellular vasculature within the redeveloping tissue. The problem with human endothelial cells (EC), which line the vasculature’s inner...

Published: 9/26/2024 | Inventor(s): Sharon Gerecht, Sravanti Kusuma

Keywords(s): Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

Cornea Mimetic Biomaterials: Vitrified Collagen-cyclodextrin Implants

Unmet Need:Due to eye injuries and ocular diseases such as keratitis and keratoconus, nearly 5 million patients in the world suffer from corneal blindness. The cornea is a transparent multilayered tissue of the eye that consists of epithelial and endothelial layers and helps focus the light on the retina. However, injuries to the cornea can cause corneal...

Published: 9/26/2024 | Inventor(s): Jennifer Elisseeff, Qiongyu Guo, Shoumyo Majumdar, Anirudha Singh

Keywords(s): Disease Indication, Eye Disorders, Implanted Device, Implants, Keratoconus, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Keratoconus

Wound Healing Compositions Comprising Biocompatible Cellulose Hydrogel Membranes and Methods of Use Thereof

Unmet NeedCorneal lacerations are a common type of eye injury. These can occur in varying degrees of severity, and in many cases the wound is non-self-sealing. This type of injury requires significant intervention including sutures and, in some cases, many layers of grafts. During the course of treatment patients are required to wear bandages that can...

Published: 9/26/2024 | Inventor(s): Jennifer Elisseeff, Daniel Mulreany, Qiongyu Guo, Morgana Trexler, Jennifer Breidenich, Jeffrey Maranchi, Iossif Strehin, Jemin Chae, Oliver Schein, Russel Mccally, Jenna Graham, Julia Patrone, Marcia Patchan, Xiomara Calderon-Colon

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Outgassing of Hyperbarically Loaded Polymeric Materials for Biomedical Applications

Unmet NeedTherapeutic gas delivery remains one of the greatest challenges in tissue engineering. Consequently many technologies and approaches have been developed but all lackeffective ways to deliver sufficient therapeutic gas, such as oxygen, to targeted regions within deeper tissue. This invention introduces a means of delivering therapeutic gases...

Published: 9/26/2024 | Inventor(s): Warren Grayson, Colin Cook

Keywords(s): Disease Indication, Drug Delivery Vehicle, Implantation Method, Implanted Device, Implants, Therapeutic Devices, Therapeutic Matter, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Wound Healing

A Microfabricated Multiple Actuation Device for Mechanical Conditioning of 3D Microtissues

We have recently demonstrated an approach that enables mechanical stimulation of microtissues via magnetic actuation of magnetic microspheres bonded to one of the cantilevers in each device (ALL THREE ZHAO REFS). This has notably allowed measurement of the mechanical stiffness of such constructs, and hence analysis of the relative contribution of cells...

Published: 9/26/2024 | Inventor(s): Fan Xu, Ruogang Zhao, Tristin Metz, Alan Liu, Yu Shi, Daniel Reich

Keywords(s): Implanted Device, Implants, Therapeutic Devices, Therapeutic Method, Therapeutics, Tissue Engineering/Regenerative Devices

Nanofiber wraps and sheaths to minimize inflammation and scarring

This invention describes a novel semi-permeable nanofiber construct in the form of a wrap or sheath that can prevent inflammatory scarring at primary nerve or vessel repair site. The wrap/sheath consists of a nanofiber mesh with thickness ranging from 50 to 500 m and pore size of less than 10 m, and can be used in the form of a sheet wrapping around...

Published: 9/26/2024 | Inventor(s): Zuhaib Ibrahim, Hai-Quan Mao, Kellin Krick, Russell Martin, Gerald Brandacher, Karim Sarhane

Keywords(s): Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

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