Search Results - brian+minnillo

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ENGINEERED CELLS EXPRESSING PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) OR A MODIFIED FORM THEREOF AND RELATED METHODS

Unmet NeedProstate cancer is the second leading cause of cancer related death in American men and it is estimated that approximately 164,690 new cases will be diagnosed in 2018. Various treatment strategies, including surgery, radiation and chemotherapy, exist for prostate cancer but their success depends on the stage of the cancer at diagnosis. Novel...

Published: 6/27/2024 | Inventor(s): Martin Pomper, David Huss, Hyam Levitsky, Il Minn

Keywords(s): Biologics, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Large Animal Cell Lines, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Whole cell

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies

Compositionally Defined Plasmid DNA/Polycation Nanoparticles and Methods for Making the Same

Unmet NeedGene therapy can be a cure-all for genetic disorders, and can be a promising therapy for diseases such as cancer, neurodegenerative diseases, neurological disorders, heart disease or diabetes. The success of gene therapy is dependent on the safety, efficacy, and specificity of the treatment. The delivery vehicle, also known as a vector, is...

Published: 6/28/2024 | Inventor(s): Hai-Quan Mao, Yizong Hu, Martin Pomper, Heng-wen Liu, Il Minn, Christopher Ullman, Christine Carrington

Keywords(s): Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Therapeutic Modalities > Gene Therapies, Clinical and Disease Specializations > Oncology

Compositions of nucleic acid-containing nanoparticles for in vivo delivery

Unmet NeedGene therapy has the potential to offer a one-time cure for severe, debilitating diseases that were previously untreatable or required chronic therapy. While a few viral-based gene therapies have recently received FDA approval, safety concerns around viral-based gene therapies continue to limit their clinical development. Non-viral strategies...

Published: 6/27/2024 | Inventor(s): Hai-Quan Mao, Il Minn, Yong Ren, Jose Santos, John-Michael Williford, Maani Archang, Martin Pomper

Keywords(s): Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Transcriptionally Targeted and CPG-free Plasmid for Theranostic Gene Therapy

Unmet NeedHepatocellular carcinoma (HCC) is the third leading cancer in the US with a ~twenty percent (20%) survival rate. HCC develops typically in the inflammatory environment of the liver caused by infections or liver disease. Therefore, it is essential to have highly targeted anti-cancer therapies to achieve clinical efficacy. Currently, viral gene...

Published: 6/27/2024 | Inventor(s): Jordan Green, Martin Pomper, Camila Gadens Zamboni, Hannah Vaughan, Il Minn

Keywords(s): Biologics, Cancers, Disease Indication, Gene Therapy, Hepatocellular Carcinoma, Liver Cancer, Nucleic Acid, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology > Hepatocellular Carcinoma

Competitive PSMA Binding Agents for Reduction of Non-target Organ Uptake of Radiolabeled PSMA Inhibitors for PSMA Positive Tumor Imaging and Radiopharmaceutical Therapy

Unmet NeedProstate cancer is the second leading cause of cancer related death in American men and it is estimated that approximately 164,690 new cases will be diagnosed in 2018. Elevated prostate-specific membrane antigen (PSMA) serves as a biomarker for prostate cancer and as well as primary clear cell renal carcinoma (ccRCC). However, PSMA is also...

Published: 6/27/2024 | Inventor(s): Martin Pomper, Ronnie Mease, Sangeeta Ray, Il Minn

Keywords(s): Cancers, Combination, Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Prostate Cancer, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Oncology > Prostate Cancer, Clinical and Disease Specializations > Men's Health, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets

PSMA-based Molecular-genetic Reporter System

PSMA-based Molecular-genetic Reporter SystemJHU REF: C12881Invention Novelty: A method of using the prostate-specific membrane antigen (PSMA) in combination with molecular reporting systems as an expression system to deliver the PSMA gene for diagnosis and imaging of prostate cancer.Value Proposition:PSMA is ideally suited to becoming a reporter because...

Published: 6/27/2024 | Inventor(s): Martin Pomper, Shawn Lupold, Mark Castanares, Il Minn

Keywords(s): Antigens, Basic Research Biomarker, Cancers, Cell Signaling, Discovery/Research Tools, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Positron Emission Tomography (PET), Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Medical Devices, Technology Classifications > Research Tools

Visualization of Registered Subsurface Anatomy

C11159: Visualization of Registered Subsurface Anatomy Value Proposition: This technology uses a near-infrared imager, suitable for use in pre-clinical trials and a system capable of providing real-time fused visualizations of the urinary tract in robotic surgery. Technical Details: Johns Hopkins University inventors disclose details for...

Published: 6/27/2024 | Inventor(s): Russell Taylor, Hiep Nguyen, Thiusius Savarimuthu, Brian Minnillo, Rajesh Kumar

Keywords(s): Interventional and Surgical Systems, Surgical Navigation

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices