Search Results - clinical+and+disease+specializations+%3e+autoimmunity

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Method of enhancing anti-inflammatory properties of extracellular vesicles

Value Proposition· Promotes adenosine production to inhibit proinflammatory cytokine release· Promotes regulatory T cells expansion· Suppresses effector immune responses· Amplifies a natural, local anti-inflammatory signal, which lowers risk of unintended side effects· Targets specific inflammatory microenvironments to minimize...

Published: 1/15/2026 | Inventor(s): Kenneth Witwer, Matias Ostrowski, Paula Soledad Perez, Tomas Grosso, Martina Fabiano

Keywords(s):

Category(s): Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Inflammation > Chronic Inflammatory Diseases

Gas6-functionalized extracellular vesicles for treatment of inflammatory conditions

Value Proposition· Superior Anti-Inflammatory Potency: This membrane-associated GAS6 demonstrates over 10-fold higher anti-inflammatory activity compared to equivalent amounts of soluble recombinant GAS6 proteins. · Dual Mechanism of Action: Inhibits pro-inflammatory cytokine production and concurrently stimulates anti-inflammatory responses,...

Published: 1/15/2026 | Inventor(s): Kenneth Witwer, Matias Ostrowski, Martina Fabiano, Alan Adamczyk

Keywords(s):

Anti- TFAM Antibody Detection Assay Predicting Lethal Cardiovascular Events, damage accrual and malignancy in Lupus Patients

Value Proposition:· Specific biomarker for the detection of major adverse events, including thrombosis, in systemic lupus patients.· Serum samples are easily accessible for biomarker detection.· High specificity for thrombotic (clotting) event risk, malignancy and death.· Leverages common laboratory tests for detection for smooth...

Published: 1/15/2026 | Inventor(s): Felipe Andrade, Jose de Jesus Eduardo Gomez-Bañuelos

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity > Systemic Lupus Erythematosus, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Inflammation > Chronic Inflammatory Diseases, Clinical and Disease Specializations > Research Tools > Assays, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics

Novel Therapeutic Drug for Multiple Sclerosis

INVENTION NOVELTY This molecule, through its action on a unique target that is different from current therapeutic treatments for MS, has both immunosuppressive and neuromodulatory properties that will better prevent the progression of MS and repair the neuronal damage caused by the immune cells in MS. Currently, there are no MS drugs in the market...

Published: 1/15/2026 | Inventor(s): Paul Kim, Michael Kornberg, Peter Calabresi, Solomon Snyder

Keywords(s): Chronic Inflammatory Diseases, CNS and Neurological Disorders, Disease Indication, Multiple Sclerosis, Multiple Sclerosis (MS), Neurodegeneration, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Polymeric Nanoparticle Genetic Vaccines

Value PropositionVersatile immunotherapy platform with the ability to specifically target antigen presenting cells (APCs) ) following systemic delivery and without requiring targeting ligands to improve treatment efficacy. Flexibility to modulate the immune system through activation or inducing tolerance.Useful as a preventative strategy or therapeutic...

Published: 1/15/2026 | Inventor(s): Jordan Green, Elana Ben-Akiva, Johan Karlsson, Stephany Tzeng, Kelly Rhodes, Sarah Neshat

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

3D Shell MEAs for Electrically Active Organoids

Value Proposition· 3D shell MEAs is a novel platform for encapsulation, electrical stimulation, and recording of organoids· Electrophysiological measurements of electrically active 3D organoids. · Relevant to brain development, neurological disorders, drug screening; neuromorphic computing and brain-machine interfaces; and organoid...

Published: 1/15/2026 | Inventor(s): David Gracias, Lena Smirnova, Qi Huang

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Motor Neuron Diseases, Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Research Stem Cells

Profiling of Interferon signaling to diagnose autoimmune disorders

Unmet Need / Invention Novelty: Diagnosing an autoimmune disease using standard laboratory tests is challenging and often requires secondary validation due to high rates of false positives and overlapping biological signatures with other diseases. There is a critical need for an improved method to detect autoimmune disease signatures in tissue collected...

Published: 1/15/2026 | Inventor(s): Livia Casciola-Rosen, Antony Rosen, John Hall

Keywords(s): Autoimmune Diseases, Basic Research Biomarker, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Inflammatory Disorders, Research Instrument

Category(s): Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Biomarkers, Clinical and Disease Specializations > Autoimmunity

Sialylation of TLR2 Recognized by Siglec15 Initiates Cell-Fusion of Osteoclasts

Unmet Need:According to the NIH, up to 24 million Americans suffer from autoimmune disease and the prevalence is rising. Additionally, by 2020 one in two Americans over age 50 are expected to be at risk for developing osteoporosis of the hip and even more will be at risk developing osteoporosis at any site in the skeleton. Research is ongoing to hinder...

Published: 1/15/2026 | Inventor(s): Xu Cao

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity

Engineered Tolerogenic Artificial Antigen-presenting Cells for Specific Expansion of Regulatory T Cells

Unmet NeedGlobal incidence of autoimmune disease is on the rise, and currently one in twelve Americans (including one in 9 women) suffer from autoimmune disease. Particularly, Type 1 Diabetes (T1D) represents a highly prevalent autoimmune disease, affecting over 20 million people. These diseases occur when the body’s immune system incorrectly attacks...

Published: 1/15/2026 | Inventor(s): Jordan Green, Jamie Spangler, Stephany Tzeng, Kelly Rhodes, Giorgio Raimondi, Marcos Iglesias Lozano, Jakub Tomala, Derek VanDyke, Randall Meyer

Keywords(s): Autoimmune Diseases, Biologics, Discovery/Research Tools, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Transplantation, Clinical and Disease Specializations > Diabetes > Type 1 Diabetes, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Cell Therapies

Cationic Biodegradable Polymer Compositions of Biomimetic Particles including Artificial Antigen Presenting Cells

Unmet NeedOver the past decade, a myriad of immune cell therapies based on the infusion of allogeneic immune cells into patients have been tested and progressed in clinical applications. Despite continual advances, immune cell therapy via antigen presenting cells is relatively expensive and time consuming, so biomimetic materials have been applied to...

Published: 1/15/2026 | Inventor(s): Jordan Green, Jonathan Schneck, Alyssa Kosmides Galaro, Randall Meyer, John Hickey, Kelly Rhodes

Keywords(s): Autoimmune Diseases, Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics, Whole cell

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Immunotherapies, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Autoimmunity

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