Search Results - clinical+and+disease+specializations+%3e+neurology+%3e+neuropathy

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Myelin Protein Zero (MPZ)-targeting Compounds and Uses Thereof

Unmet NeedPeripheral nerve injuries require optimally timed intervention to maximize functional recovery and minimize permanent nerve death and negative impacts to quality of life. Current treatment plans rely primarily on monitoring for spontaneous healing or an indication that there must be surgical intervention, an approach that hinges on accurate...

Published: 6/28/2024 | Inventor(s): Martin Pomper, Catherine Foss, Sami Tuffaha, William Padovano, Bei Cheng

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

Combined MAPK and NAMPT Inhibition: Greater Efficacy in Axonal Degeneration

Value PropositionDemonstrates synergistic effect of targeting two biochemical pathways.Offers possible disease-modifying therapy for degenerative diseases of the axons.Possible treatment to minimize damage from acute brain injury.Unmet NeedDegeneration of axons is a hallmark feature of various neurological conditions. Deterioration of axons is observed...

Published: 6/28/2024 | Inventor(s): Vassilis Koliatsos, Athanasios Alexandris, Jiwon Ryu

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neuropathy, Clinical and Disease Specializations > Neurology > Neurodegeneration

3D Shell MEAs for Electrically Active Organoids

Value Proposition· 3D shell MEAs is a novel platform for encapsulation, electrical stimulation, and recording of organoids· Electrophysiological measurements of electrically active 3D organoids. · Relevant to brain development, neurological disorders, drug screening; neuromorphic computing and brain-machine interfaces; and organoid...

Published: 6/28/2024 | Inventor(s): David Gracias, Lena Smirnova, Qi Huang

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Motor Neuron Diseases, Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Research Stem Cells

Long non-coding RNA as therapeutic target for treatment of neuropathic pain

Value Proposition· Identification of a unique therapeutic target for neuropathic pain.· Technology exhibits a clearly defined mechanism for propagation of neuropathic pain. · Expression is widespread and may be implicated in other pathological processes.Technology DescriptionResearchers at Johns Hopkins have identified a therapeutic...

Published: 6/27/2024 | Inventor(s): Yuan-Xiang Tao

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Neuropathy, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities

Novel Triazole Compounds to Treat Nav1.6-related Brain Disorders

Unmet NeedAbnormal behavior of sodium (Nav) channels is linked to a variety of epilepsy syndromes, movement disorders, and neuropathic pain. While researchers continue to elucidate the roles of different Nav channel isoforms within a variety of neurological disorders, current therapeutics influence numerous Nav channel isoforms, resulting in off-target...

Published: 6/27/2024 | Inventor(s): Frank Bosmans, Dimpy Kalia

Keywords(s): Antagonists/Inhibitors, CNS and Neurological Disorders, Disease Indication, Epilepsy, Neuropathy, Non-novel, Novel, Off-the-shelf, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Neuropathy, Clinical and Disease Specializations > Neurology > Epilepsy

Pirt-GCaMP3 Mice

Invention novelty: Primary sensory neurons in the DRG play essential role in initiating somatosensory such as pain, itch, and touch by directly sensing various sensory stimuli like mechanical, chemical, and thermal stimuli. Dysfunction of these neurons often leads to various pathological conditions including chronic pain and itch. Currently, no one...

Published: 6/27/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Itch, Knock In Mouse Model, Mouse Model, Neuropathy

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Itch, Clinical and Disease Specializations > Neurology > Neuropathy

Ethoxyquin and Derivatives for Treatment of Peripheral Neuropathies and Other Neurodegenerative Disorders

Peripheral neuropathies are a group of neurodegenerative disorders affecting the peripheral nerves. Currently there is no effective therapy that prevents nerve degeneration except in cases of autoimmune peripheral neuropathies. Wehave now identified a compound, ethoxyquin (EQ), that prevents nerve degeneration in chemotherapy-induced peripheral neuropathy...

Published: 6/27/2024 | Inventor(s): Weiran Chen, Jing Zhu, Ahmet Hoke

Keywords(s): CNS and Neurological Disorders, Disease Indication, Neuropathy, Non-novel, Off-the-shelf, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities

Medical Device for Treatment of Ulnar Neuropathy

C04545: Medical Device for Treatment of Ulnar Neuropathy Value Proposition: Key Benefits • Stand alone device for treating ulnar neuropathy • Affordable • Safe • Easy to wearTechnical Details: UlnarGuardTM is a non-invasive medical device used for treating pain and disability due to ulnar neuropathy. It is designed to worn under clothing so that...

Published: 6/27/2024 | Inventor(s): Justin Mcarthur, Beth Hogans

Keywords(s): CNS and Neurological Disorders, Disease Indication, Neuropathy, Orthotic Device, Orthotics, Therapeutic Devices, Therapeutics, Ulnar Neuropathy

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neuropathy, Clinical and Disease Specializations > Neurology > Ulnar Neuropathy, Technology Classifications > Medical Devices > Orthopedic Devices, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Neurology