Search Results - in+vitro+diagnostics+(old)

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A DNA methylation and genotype specific biomarker of suicide attempt
Novel Biomarkers for Predicting Suicide RiskJHU REF: [C12394]Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting suicide risk. Value Proposition: Almost 30,000 people die of suicide each year in the United States, and 1 million people die worldwide. In the teenage population, it is the second leading cause of...
Published: 3/13/2025   |   Inventor(s): Holly Wilcox, Zachary Kaminsky
Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epigenetic, In Vitro Diagnostics, In Vitro Diagnostics (Old), Methylation, Prognostic Biomarker, Psychiatric Diseases, Suicidal Impulses, Suicide/Suicidal Impulses
Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Clinical and Disease Specializations > Psychiatry > Suicidal Impulses
Urinary Glycoproteins for the Early Detection of Aggressive Prostate Cancer
Unmet NeedAccording to the American Cancer Society, prostate cancer is one of the most commonly diagnosed cancers and is the second leading cause of cancer death in men. However, most patients with prostate cancer have the low-risk, nonaggressive form that does not require invasive intervention or treatment. The gold standard of diagnosing men with...
Published: 3/14/2025   |   Inventor(s): Hui Zhang, Mingming Dong, Tung-Shing Lih
Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prostate Cancer
Category(s): Technology Classifications > Diagnostics > Prognostic Biomarkers, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > In Vitro Diagnostics
Novel Biomarker for Breast Cancer Detection Outcome and Treatment Sensitization to Nucleolin and CDK Inhibitors
Unmet Need: Despite widespread research efforts, breast cancer remains the second leading cause of cancer deaths in women. There is an urgent need to identify novel biomarkers and treatment strategies against aggressive forms of breast cancer to improve prognosis and therapy. Technical Details: Johns Hopkins researchers have identified a novel biomarker...
Published: 3/14/2025   |   Inventor(s): Vanessa Merino, Saraswati Sukumar, Martin Pomper
Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prognostic Biomarker, Prostate Cancer
Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Therapeutic Modalities > Targets
Antigens Derived from Biofilm-like Microcolony Persister Form of Borrelia burgdorferi Improve Serodiagnosis of Lyme Disease
Unmet NeedLyme disease is one of many tick-transmitted diseases. Further investigation has revealed that Lyme disease is caused by the bacterium Borrelia burgdoferi. These bacteria transmit to humans via an infected deer tick and has affected over 25,000 Americans in the United States in 2002. Currently there are estimated to be 300,000 cases a year...
Published: 3/14/2025   |   Inventor(s): Ying Zhang
Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics (Old), Infectious Diseases, Lyme Disease
Category(s): Clinical and Disease Specializations > Infectious Diseases > Lyme Disease, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers
Method to Use Viral and Host Methylation Markers for Cervical Cancer Screening and Triage in Liquid Prep, Serum/plasma, and Urine: PCR and Sequencing Based Process Methods
Novel Method for Cervical Cancer ScreeningJHU REF: C13649Invention novelty: This invention is a diagnostic method for diagnosis and progression monitoring of premalignant lesions in cervical cancer via DNA methylation and quantitative Methylation Specific PCR (qMSP).Value Proposition:Currently, the primary diagnostic for cervical cancer is a Papanicolaou...
Published: 3/13/2025   |   Inventor(s): Rafael Guerrero-Preston, David Sidransky
Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Tool, Disease Indication, Epigenetic, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Diagnostics (Old), Infectious Diseases, Measurement Tool, Methylation, Viral Infections
Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections
EXoO-Tn Tag-n-Pin the Pan-Carcinoma Tn Antigen in Human Proteome
Unmet NeedAberrant glycosylation has been implicated as a mechanism of cancer progression. Accordingly, identifying the differences in glycan structures within clinical specimens, cancer, and normal cells provides a unique opportunity to identify new biomarkers and therapeutic targets. In particular, Tn antigen (Tn) is a simple O-linked glycan structure...
Published: 3/14/2025   |   Inventor(s): Hui Zhang, Weiming Yang
Keywords(s): Analytical Method, Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool, Pancreatic Cancer, Pancreatic ductal adenocarcinoma
Category(s): Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers
Long Noncoding RNAs as Therapeutic and Diagnostic Markers for Childhood Cancer Medulloblastoma
Unmet NeedMedulloblastoma (MB) is the most common pediatric brain tumor and requires aggressive therapy in high-risk cases. MB is frequently resistant to treatment and is associated with high morbidity and mortality in affected individuals. There are four distinct molecular subgroups of MB (WNT, SHH, Group 3, and Group 4), which are characterized by...
Published: 3/14/2025   |   Inventor(s): Ranjan Perera, Keisuke Katsushima
Keywords(s): Biomarker, Cancers, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics (Old), Novel, Predicted Novelty, Target, Therapeutic Matter, Therapeutics
Category(s): Clinical and Disease Specializations > Oncology > Medulloblastoma, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets
An ECL-based Autoantibody Assay for Early Diagnosis of T1D Using a Membrane-spanning ZnT8 Antigenic Domain
Unmet NeedApproximately 1.25 million people in the US have type 1 diabetes (T1D) and the rates of newly diagnosed cases in children are on the rise each year. T1D is caused by the development of an autoimmune reaction to pancreatic β cells. The first detectable sign of β cell autoimmunity is the appearance of diabetes-associated autoantibodies, which...
Published: 3/14/2025   |   Inventor(s): Dax Fu, Chengfeng Merriman, Liping Yu, Yong Gu
Keywords(s): Assay, Biomarker, Clinical Diagnostics, Diabetes, Diagnostic Biomarker, Diagnostic Tool, Disease Indication, In Vitro Diagnostics (Old), Measurement Tool, Metabolic Disorders, Type II Diabetes
Category(s): Clinical and Disease Specializations > Diabetes > Type 1 Diabetes, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > In Vivo Diagnostics, Clinical and Disease Specializations > Diabetes > Type 2 Diabetes, Technology Classifications > Diagnostics > Diagnostic Biomarkers
An Efficient Phage Display Based Protease Activity Profiling Platform
Unmet NeedProtein cleavage is a fundamental molecular process, essential to cellular viability and tissue physiology across all kingdoms of life. Human proteases comprise a diverse set of enzymes with at least 569 members, making up five distinct catalytic classes. Cancer associated protease activities are often dysregulated and usually contribute to...
Published: 3/14/2025   |   Inventor(s): Harry Larman, Gabriel Roman-Melendez, Thiagarajan Venkataraman
Keywords(s): Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool, Research Reagent, Viruses
Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Viruses, Technology Classifications > Diagnostics > In Vitro Diagnostics
Genomic Drivers of Response to Immunotherapy
Unmet NeedTumor mutational burden (TMB) is a measurement of mutations carried by tumor cells and is but one emerging biomarker for some types of cancer, including non-small cell lung cancer.  Currently, there is a lack of standardization for tumor mutational burden calculation and reporting. Different tests may report different measurements, and since...
Published: 3/14/2025   |   Inventor(s): Valsamo Anagnostou, Victor Velculescu, Noushin Niknafs Kermani
Keywords(s): Biomarker, Clinical Diagnostics, In Vitro Diagnostics (Old), Prognostic Biomarker, Risk Stratification
Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Computers, Electronics & Software > Algorithms
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