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Conditional expression of human SHH mouse

Unmet Need:Every year, approximately 6,000 children are born with Down syndrome worldwide (see CDC). Down syndrome is ubiquitously associated with cognitive delays, and sometimes accompanied by additional neurological defects (see NDSS). Unfortunately, little is known about how these cognitive deficits arise. Some studies suggest that sonic hedgehog...

Published: 3/13/2026 | Inventor(s): Roger Reeves, Donna Klinedinst, Fabian Fernandez, Feng Gao

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices

Use of Non-labeled Sugars in MRI

Value Proposition: ADVANTAGES: • Provides an alternative approach to measure MR contrast sensitive to both metabolic and vascular properties (perfusion and permeability) of tissue. • Uses a natural biodegradable compound that is already available in the clinic, without the need for paramagnetic, magnetic, or radioactive isotope labeling....

Published: 3/12/2026 | Inventor(s): Guanshu Liu, Dmitri Artemov, Yoshinori Kato, Kannie Chan, Michael Mcmahon, Peter van Zijl

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

A handheld steerable curved cutting device

Unmet NeedACL reconstruction surgery requires drilling a straight path past the LCL and along the edge of the tibia. This may result in injury to the LCL and tibia that could be avoided if it were possible for a different drilling path to be taken. This issue of orthopedic drills only being able to create straight pathways appears in many surgeries,...

Published: 3/13/2026 | Inventor(s): Farshid Alambeigi, Mehran Armand

Keywords(s): Interventional and Surgical Systems, Mechanical Cutters/Incision Tools, Surgical Instruments

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices

Endoscopic Accessory Mechanical Vibration/Oscillation Device for Use in Endoscopic Retrograde Cholangiopancreatography (ERCP)

Devices and methods transmit mechanical motion to guidewires and endoscopic tools for controlled access through challenging anatomies, addressing entry challenges and reducing trauma.Unmet Need Medical professionals face challenges in smoothly advancing guidewires and endoscopic accessory tools through challenging patient anatomies due to difficult...

Published: 3/13/2026 | Inventor(s): Kyle Cowdrick, Marc Chelala, Maria Torres, David Gullotti, Amir Soltanianzadeh, George Coles, Youseph Yazdi, Pankaj Pasricha, Sritam Rout, Ryan Wales, Demetri Monovoukas, Favreau John

Keywords(s): Cannulas, Interventional and Surgical Systems, Surgical Instruments, Surgical Tubing

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices

Intra-operative Orthognathic Biomechanical Simulation

Value Proposition· Real-Time Operation Adjustments: The system provides live 3D positioning updates of the donor and recipient anatomies, allowing for instant feedback for surgeons. · Mastication Simulation: The technology spontaneously identifies ideal positioning of the donor face to allow for optimal recipient mastication post-op.· Mid-Surgery...

Published: 3/12/2026 | Inventor(s): Ryan Murphy, Mehran Armand, Peter Liacouras, Gerald Grant, Chad Gordon, Ehsan Basafa

Keywords(s): Integrated Imaging System, Interventional and Surgical Systems, Surgical Navigation

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Surgery, Applied Physics Laboratory > Applied Physics Laboratory, Clinical and Disease Specializations > Transplantation, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Plastic Surgery, Technology Classifications, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Traumatic Injury > Craniomaxillofacial Trauma

Patient-specific Trackable Cutting Guides

Value Proposition· Novel Mechanism: Bone-anchored guide with an attachment device, an integrated cut-location indicator, and an adjustable arm-support that carries a trackable feature.· Disease-Modifying Potential: Increases cut accuracy, reducing malalignment, lowering revision risk, and preserving bone stock through precisely guided resections.· Broad...

Published: 3/12/2026 | Inventor(s): Mehran Armand, Gerald Grant, Peter Liacouras, Ryan Murphy, Chad Gordon

Keywords(s): Interventional and Surgical Systems, Surgical Navigation

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal > Osteoporosis, Applied Physics Laboratory > Applied Physics Laboratory

Unpowered Respiratory Protective Hood

Value Proposition· Reduces contamination risk in doffing procedures: The integrated design of the disclosed technology simplifies the removal of PPE components, reducing doffing errors (self-contamination from mistakes when removing PPE). · Dual-pathway ventilation design: Bilayer check valves direct filtered air across the face shield (preventing...

Published: 3/12/2026 | Inventor(s): Matthew Petney, Patience Osei, Laura Scavo, Youseph Yazdi, William Patterson

Keywords(s): Orthotic Device, Orthotics, Therapeutic Devices, Therapeutics

Category(s): Technology Classifications > Medical Devices > Orthopedic Devices, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices

Methods and Systems for Insertion of a Medical Device during a Medical Imaging Process

Technical Problem Current medical procedures for prostate biopsy and therapy face challenges with inaccurate needle placement due to dynamic tissue deformation and limited access within closed MRI scanners, where traditional robots and mechanical linkages are not compatible and suffer from low signal-to-noise ratio and invasive methods. How it works · Leveraging...

Published: 3/12/2026 | Inventor(s): Gabor Fichtinger, Iulian Iordachita, Louis Whitcomb, Robert Susil, Ergin Atalar, Axel Krieger

Keywords(s): Interventional and Surgical Systems, Surgical Navigation

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices

Patient Triage Using Wearable Devices

JHU Ref #: [C17108, C17833, and C17521]Value Proposition· Wearable, Patch-Based Technology: Designed to autonomously monitor and/or treat biological features, enabling rapid, non-invasive triage and care in emergency settings.· Three Sensing Modalities: A handheld device collects and displays the real-time physiological data of multiple...

Published: 3/13/2026 | Inventor(s): Amir Manbachi, Nicholas Theodore, Aliaksei Pustavoitau

Keywords(s):

Category(s): Technology Classifications > Medical Devices

Apparatus and Method for modular ultrasound and photoacoustic imaging and interactive guidance using a position-tracked modular imaging framework

Value Proposition· Wearable ultrasound system that is adaptable to different patient physiologies and ages.· Allows for longitudinal and non-invasive monitoring of internal organs of critical care patients.· Applicable across a broad range of organ systems and disease indications.· Simulation-aided interactive guidance simplifies...

Published: 3/13/2026 | Inventor(s): Jeeun Kang, Emad Boctor, Ananya Tandri

Keywords(s):

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Imaging

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