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Device and Methods for Engineering 3D Complex Tissues

Value Proposition· Precise: Enables precise engineering of complex 3D tissue structures using aligned cell sheets and thermoresponsive scaffolds· Buildable: “tissue origami” platform allows folding, molding, and positioning of tissues in geometrically complex configurations· Flexible: Superior cell sheet detachment via flexible substrate...

Published: 9/12/2025 | Inventor(s): Deok-Ho Kim, Nisa Williams, Alex Jiao

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Medical Devices > Regenerative Medicine

3D-printed Calcium Peroxide-Polycaprolactone (CPO-PCL) Scaffold

Value Proposition:· Controlled Oxygen Release: The CPO-PCL scaffolds provide a long-term, controlled release of oxygen for up to 22 days, enhancing cellular viability in ischemic conditions without causing burst release, which minimizes cytotoxicity risks. · Enhanced Osteogenesis: Promotes early and sustained osteogenic differentiation of...

Published: 9/12/2025 | Inventor(s): Warren Grayson, Naboneeta Sarkar, Jingtong Zhao

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Orthopedic Devices, Technology Classifications > Medical Devices > Regenerative Medicine

Biodegradable Nanofiber Conical Conduits for Targeted Muscle Reinnervation

Unmet NeedThere are 2 million amputees in the United States, with limb loss attributed to diabetes mellitus, vascular disease, trauma, and malignancy of bone and joints (Amputee Coalition, 2021 and Ziegler-Graham, et al., 2008). Living with an amputation and the adoption of assistive devices like prosthetics can be challenging, with chronic pain especially...

Published: 9/12/2025 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Ahmet Hoke, Michael Lan, Bruce Enzmann, Anson Zhou, Alison Wong, Erica Lee, Sai Pinni

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Orthopedic Devices

Nanofiber Hydrogel Composite Gel to Prevent Scarring and Adhesion of Peripheral Nerves

JHU Ref #: [C17294] Value Proposition:· Application of composite hydrogel to mechanically irritated nerves can reduce perineural adhesions and scar formation.· Improves patient outcomes following peripheral nerve surgery. Technology Description· Researchers at Johns Hopkins have developed a nanofiber-hydrogel composite (NHC) material...

Published: 9/12/2025 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Sashank Reddy, Visakha Suresh, Thomas Harris, Chenhu Qiu

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Medical Devices > Plastic Surgery, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Dynamic Hydrogels

Unmet NeedOrgan/tissue regeneration remains a major area of research with few viable clinical products. A major barrier is the development of biologically accurate tissue constructs, with vascularization being a primary component. Classic static hydrogels have non-reversible crosslinks such that network is elastic at the macro-scale but limited in response...

Published: 9/12/2025 | Inventor(s): Sharon Gerecht, Rahel Schnellmann, Zhao Wei, Eugenia Volkova

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Tissue Substrates, Clinical and Disease Specializations > Wound Healing, Clinical and Disease Specializations > Cardiovascular > Vascular Diseases

A Natural Anti-inflammatory Treatment to Reduce Corneal Scarring and Dry Eye

Unmet Need:According to the WHO, approximately 4.9 million people globally are affected by bacteria that leads to corneal scarring of the eye (WHO). Additionally, in the United States alone 4.88 million people age 50 and older suffer from dry eye, which may lead to scarring of the cornea (Healthline). The cornea serves as a window to the eye, and transparency...

Published: 9/12/2025 | Inventor(s): Jennifer Elisseeff, Liam Chung, Xiaokun Wang

Keywords(s):

Category(s): Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Dry Eye Syndrome, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Medical Devices > Regenerative Medicine

A Bioinspired Composite with Mechanically Adaptable and Self-Healable Attributes

Unmet NeedEvery year millions of people are diagnosed with a variety of severe oral/bone diseases including periodontitis, large bone defects, and alveolar bone degradation. These diseases often result in the loss of bone cells in affected areas which can lead to several other complications such as osteoporosis and tooth loss. Such complications impede...

Published: 9/12/2025 | Inventor(s): Sung Hoon Kang, Santiago Orrego

Keywords(s): Industrial Manufacturing, Manufacturing Method, Microfabrication

Category(s): Technology Classifications > Industrial Tech > Materials, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Engineering Tech > Industrial Manufacturing

Artificial Corneal Device

Unmet NeedCorneal blindness affects an estimated 10 million people worldwide, particularly prevalent in the underdeveloped world. Currently, only about 10% of patients receive a corneal transplant due to a shortage of human donor corneas and difficulty in preserving the tissues. Meanwhile, even in countries with a sufficient donor supply, some patients...

Published: 9/12/2025 | Inventor(s): Esen Akpek, Gopalan Balaji, Thomas Schmiedel, Anuraag Singh

Keywords(s): Carriers/Appliers, Disease Indication, Eye Disorders, Implantation Method, Implants, Interventional and Surgical Systems, Surgical Instruments, Therapeutic Devices, Therapeutics

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Ophthalmology

Cationic Biodegradable Polymer Compositions of Biomimetic Particles including Artificial Antigen Presenting Cells

Unmet NeedOver the past decade, a myriad of immune cell therapies based on the infusion of allogeneic immune cells into patients have been tested and progressed in clinical applications. Despite continual advances, immune cell therapy via antigen presenting cells is relatively expensive and time consuming, so biomimetic materials have been applied to...

Published: 9/12/2025 | Inventor(s): Jordan Green, Jonathan Schneck, Alyssa Kosmides Galaro, Randall Meyer, John Hickey, Kelly Rhodes

Keywords(s): Autoimmune Diseases, Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics, Whole cell

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Immunotherapies, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Autoimmunity

Multiphase Transitioning Peptride Hydrogel for Use in Vascular Anastamosis

Unmet NeedThe formation of vascular anastomosis, the joining of two blood vessels, is a fairly common procedure utilized by many surgeons. All vascular bypass operations and solid organ transplants require anastomoses. However, as the vessels being anastomosed become smaller or less firm, surgeons have exponentially increasing rates of failure. In...

Published: 9/11/2025 | Inventor(s): Daniel Smith, Johanna Grahammer, Joel Schneider, Gerald Brandacher, Gabriel Brat

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

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