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A Natural Anti-inflammatory Treatment to Reduce Corneal Scarring and Dry Eye

Unmet Need:According to the WHO, approximately 4.9 million people globally are affected by bacteria that leads to corneal scarring of the eye (WHO). Additionally, in the United States alone 4.88 million people age 50 and older suffer from dry eye, which may lead to scarring of the cornea (Healthline). The cornea serves as a window to the eye, and transparency...

Published: 6/28/2024 | Inventor(s): Jennifer Elisseeff, Liam Chung, Xiaokun Wang

Keywords(s):

Category(s): Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Dry Eye Syndrome, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Medical Devices > Regenerative Medicine

A Bioinspired Composite with Mechanically Adaptable and Self-Healable Attributes

Unmet NeedEvery year millions of people are diagnosed with a variety of severe oral/bone diseases including periodontitis, large bone defects, and alveolar bone degradation. These diseases often result in the loss of bone cells in affected areas which can lead to several other complications such as osteoporosis and tooth loss. Such complications impede...

Published: 6/27/2024 | Inventor(s): Sung Hoon Kang, Santiago Orrego

Keywords(s): Industrial Manufacturing, Manufacturing Method, Microfabrication

Category(s): Technology Classifications > Industrial Tech > Materials, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Engineering Tech > Industrial Manufacturing

Hollow, Perfusable Small-Diameter Tissue Engineered Vascular Grafts

Unmet NeedCardiovascular disease, often called “heart disease,” refers to conditions that involve narrowed or blocked blood vessels that can lead to a heart attack. Approximately 43% of all cardiovascular disease cases involve coronary artery disease (CAD) and require coronary artery bypass surgery. Implantation of vascular grafts is the most common...

Published: 6/27/2024 | Inventor(s): Sharon Gerecht, Morgan Elliott, Brian Ginn, Sebastian Barreto Ortiz, Hai-Quan Mao

Keywords(s): Cardiovascular Diseases, Coronary Heart Disease, Disease Indication, Implanted Device, Implants, Peripheral Artery Disease, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Vascular Diseases

Category(s): Clinical and Disease Specializations, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Cardiovascular > Coronary Heart Disease, Clinical and Disease Specializations > Cardiovascular > Peripheral Artery Disease, Clinical and Disease Specializations > Cardiovascular > Vascular Diseases

Artificial Corneal Device

Unmet NeedCorneal blindness affects an estimated 10 million people worldwide, particularly prevalent in the underdeveloped world. Currently, only about 10% of patients receive a corneal transplant due to a shortage of human donor corneas and difficulty in preserving the tissues. Meanwhile, even in countries with a sufficient donor supply, some patients...

Published: 6/27/2024 | Inventor(s): Esen Akpek, Gopalan Balaji, Thomas Schmiedel, Anuraag Singh

Keywords(s): Carriers/Appliers, Disease Indication, Eye Disorders, Implantation Method, Implants, Interventional and Surgical Systems, Surgical Instruments, Therapeutic Devices, Therapeutics

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Ophthalmology

Cationic Biodegradable Polymer Compositions of Biomimetic Particles including Artificial Antigen Presenting Cells

Unmet NeedOver the past decade, a myriad of immune cell therapies based on the infusion of allogeneic immune cells into patients have been tested and progressed in clinical applications. Despite continual advances, immune cell therapy via antigen presenting cells is relatively expensive and time consuming, so biomimetic materials have been applied to...

Published: 6/27/2024 | Inventor(s): Jordan Green, Jonathan Schneck, Alyssa Kosmides Galaro, Randall Meyer, John Hickey, Kelly Rhodes

Keywords(s): Autoimmune Diseases, Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics, Whole cell

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Immunotherapies, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Autoimmunity

Multiphase Transitioning Peptride Hydrogel for Use in Vascular Anastamosis

Unmet NeedThe formation of vascular anastomosis, the joining of two blood vessels, is a fairly common procedure utilized by many surgeons. All vascular bypass operations and solid organ transplants require anastomoses. However, as the vessels being anastomosed become smaller or less firm, surgeons have exponentially increasing rates of failure. In...

Published: 6/27/2024 | Inventor(s): Daniel Smith, Johanna Grahammer, Joel Schneider, Gerald Brandacher, Gabriel Brat

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

A Compliant, Strong, Suturable Collagen-based Biomaterial

Unmet NeedTissue engineering and regenerative medicine hold immense promise for the future as new ways to regenerate and regrow biological tissues. An ideal tissue engineering scaffold is able to completely approximate the biochemical and mechanical properties of the tissue it is replacing, fully absorb into the body after new tissue has been established,...

Published: 6/27/2024 | Inventor(s): Anirudha Singh

Keywords(s): Industrial Manufacturing, Interventional and Surgical Systems, Novel Materials, Surgical Instruments, Suture Insertion/Removal

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine

Retinal Implantation Device

Unmet NeedMillions of people around the world suffer from retinal degenerative diseases at varying degrees of vision loss. Common to all retinal degenerative diseases is the damage to photoreceptor cells of the retina, which malfunction and disappear. Current treatments can begin with trying to “rescue” remaining photoreceptors. Unfortunately this strategy...

Published: 6/27/2024 | Inventor(s): Mandeep Singh, Kevin Wolfe, Jin Kang, Kathleen Perrino, Andrea Timm

Keywords(s): Disease Indication, Eye Disorders, Implanted Device, Implants, Macular Degeneration, Retinal Degeneration, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Retinal Degeneration, Technology Classifications > Medical Devices > Regenerative Medicine

Extracellular Matrix Scaffolds for Combination Immunotherapy

Unmet NeedThe critically important goal of regenerative medicine is the stimulation of in vivo wound healing and the production of functional tissue to repair or replace tissues loss to injury or disease. Extracellular matrix (ECM) materials are acellular tissue derived scaffolds commonly used in tissue regeneration following malignant or benign tumor...

Published: 6/27/2024 | Inventor(s): Jennifer Elisseeff, Matthew Wolf

Keywords(s): Cancers, Cell Therapy/Immunotherapy, Combination, Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutic Matter, Therapeutics, Therapy Type, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Medical Devices > Regenerative Medicine

Self-organized Vascular Networks from Human Pluripotent Stem Cells in a Synthetic Matrix

Unmet NeedTissue regeneration is a large part of a huge market for redeveloping tissues that have been damaged or have lost functionality. The success of tissue regenerative therapies is dependent on functional and multicellular vasculature within the redeveloping tissue. The problem with human endothelial cells (EC), which line the vasculature’s inner...

Published: 6/27/2024 | Inventor(s): Sharon Gerecht, Sravanti Kusuma

Keywords(s): Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

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