Search Results - technology+classifications+%3e+research+tools+%3e+microfluidics

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A mRNA Lipid Nanoparticle Incorporated Nanofiber-hydrogel Composite to Generate a Local Immunostimulatory Niche for Immunotherapy
Value Proposition:·        Creates a programmable immunostimulatory niche.·        Allows for tailor-made immune responses to vaccines and antigens.·        Flexible drug delivery platform enables mRNA therapeutics for infectious diseases and cancers.·        Applicable to existing mRNA vaccines for improved efficacy. ·        Can be utilized for novel...
Published: 3/14/2025   |   Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Zhicheng Yao, Christine Wei
Keywords(s):  
Category(s): Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Research Tools > Microfluidics
Organ-On-A-Chip Mold with Microfluidics System
Value Proposition:3D printed mold that will allow for the rapid production of chips. Improved mold design allows microfluidics between multiple cell types.Multiple organoids enable physiologically relevant therapeutic testing.Technology DescriptionResearchers at Johns Hopkins have developed a organ on a chip model to test organ interactions, pathological...
Published: 3/14/2025   |   Inventor(s): Mark Ranek, Marcus Williams, Vivek Jani, Brian Lin
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools
Digital High Resolution Melt Microfluidic Platform and Assay for Assessing Locus-specific Molecular Heterogeneity of DNA Methylation
Value Proposition·      Simple, low-cost microfluidic tool that evaluates DNA methylation using non-invasive liquid biopsy samples. ·      Allows for sensitive, specific evaluation of epigenetic biomarkers for early detection of cancer. ·      Includes software and algorithms for improved diagnostic interpretation of DNA methylation analyses. Unmet...
Published: 3/14/2025   |   Inventor(s): Tza-Huei Wang, Christine O'Keefe, Thomas Pisanic
Keywords(s):  
Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Blood & Tissue Samples
Multi-Compartment Fallopian Tube Organoid Model
Unmet Need: Existing organoid models of the fallopian tube are architecturally simplified compared to the intricate epithelial-lumen interface in scale and structure, and there remains a need in the art for multi-compartment fallopian tube organoids that architecturally simulate the intricate architecture of the epithelial-lumen interface in structural...
Published: 3/14/2025   |   Inventor(s): Meng Horng Lee, Gabriella Russo, Denis Wirtz, Ashleigh Crawford, Wenxuan Du
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Stem Cells, Technology Classifications > Research Tools > Microfluidics, Clinical and Disease Specializations > Oncology
Multiplexed, Continuous-Flow, Droplet-Based Platform for High-Throughput Genetic Detection
Unmet NeedMaintaining levels of crop production has become increasingly critical amidst growing populations and other emerging challenges for the $300 billion global crop market. Traditional crossbreeding of plants for desirable phenotypic traits is being improved by genetic marker assisted selection (MAS), where known genetic markers associated with...
Published: 3/13/2025   |   Inventor(s): Tza-Huei Wang, Kuangwen Hsieh, Helena Zec, Lingshu Liu, Aniruddha Kaushik, Yue Yun
Keywords(s): Assay, Clinical Diagnostics, Crop Management, In Vitro Diagnostics, Microfluidic, Operations Management
Category(s): Technology Classifications > Industrial Tech > Agriculture, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Diagnostics, Technology Classifications > Industrial Tech, Technology Classifications > Research Tools, Technology Classifications > Engineering Tech > Agriculture
High-throughput microfluidic platform for high-density immobilization and parallelized quantitative real-time measurements of droplets
Unmet Need:Droplet platforms, which compartmentalize samples into encapsulated droplets for high-throughput analysis, have been used to detect and analyze diverse molecules, including nucleic acids, proteins, and single cells, at a higher sensitivity than traditional methods. Despite advantages in sensitivity and throughput, most existing droplet analysis...
Published: 3/14/2025   |   Inventor(s): Tza-Huei Wang, Christine O'Keefe, Aniruddha Kaushik
Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics (Old), In Vitro Research Tool, Microfluidic, Target-based Screening Tool
Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays
Streamlined Platform for Bacterial Identification and Antimicrobial Susceptibility Test
Unmet NeedFor managing dangerous infections, clinicians need to know what bacteria strain(s) is/are causing the infections, the bacterial loads, and the antibiotic resistance profile of the bacteria.  Without knowing this vital information in a timely manner, it is impossible to begin using narrow-spectrum antibiotics that can effectively treat the...
Published: 3/13/2025   |   Inventor(s): Tza-Huei Wang, Pornpat Athamanolap, Liben Chen, Kuangwen Hsieh
Keywords(s): Assay, Bacterial Infections, Clinical Diagnostics, Diagnostic Tool, Disease Indication, In Vitro Diagnostics, Measurement Tool, Microfluidic
Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools
Parallelization of Fission and Fusion Operations for High Throughput Generation of Combinatorial Droplets
Recent research in digital microfluidics has burgeoned as droplets can function as miniaturized reactors in biological and chemical applications. Droplet microfluidic platforms boast the ability to generate many reactions within short time periods. However, most droplet platforms digitize samples into discrete droplets and are limited to the analysis...
Published: 3/13/2025   |   Inventor(s): Helena Zec, Tushar Rane, Tza-Huei Wang
Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Microfluidic, Target-based Screening Tool
Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Microfluidics
Multiplexed Screening of a Large Library of Biological Samples Through On-demand Droplet Generation and Fusion
A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection...
Published: 3/13/2025   |   Inventor(s): Tushar Rane, Wen-Chy Chu, Helena Zec, Tza-Huei Wang
Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Microfluidic, Target-based Screening Tool
Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Microfluidics
Microfluidic Settling Velocity Based Separation of Synthetic and Biological Particles
Novel Microfluidic Blood Fractionation DeviceJHU REF: [C11659]Invention novelty: Separation of components of blood by microfluidic device without damaging its morphology. Value PropositionThe proposed invention possesses several advantages over the current technologies employed for blood fractionation as follows: Reduction in infrastructure costs and...
Published: 3/13/2025   |   Inventor(s): Chengxun Liu, German Drazer, Liesbet Lagae, Jorge Bernate
Keywords(s): Clinical Diagnostics, In Vitro Diagnostics, Sample Prep Method
Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Specimen Handling, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Microfluidics
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