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Digital High Resolution Melt Microfluidic Platform and Assay for Assessing Locus-specific Molecular Heterogeneity of DNA Methylation

Value Proposition· Simple, low-cost microfluidic tool that evaluates DNA methylation using non-invasive liquid biopsy samples. · Allows for sensitive, specific evaluation of epigenetic biomarkers for early detection of cancer. · Includes software and algorithms for improved diagnostic interpretation of DNA methylation analyses. Unmet...

Published: 6/28/2024 | Inventor(s): Tza-Huei Wang, Christine O'Keefe, Thomas Pisanic

Keywords(s):

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Blood & Tissue Samples

Multi-Compartment Fallopian Tube Organoid Model

Unmet Need: Existing organoid models of the fallopian tube are architecturally simplified compared to the intricate epithelial-lumen interface in scale and structure, and there remains a need in the art for multi-compartment fallopian tube organoids that architecturally simulate the intricate architecture of the epithelial-lumen interface in structural...

Published: 6/28/2024 | Inventor(s): Meng Horng Lee, Gabriella Russo, Denis Wirtz, Ashleigh Crawford, Wenxuan Du

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Stem Cells, Technology Classifications > Research Tools > Microfluidics, Clinical and Disease Specializations > Oncology

Multiplexed, Continuous-Flow, Droplet-Based Platform for High-Throughput Genetic Detection

Unmet NeedMaintaining levels of crop production has become increasingly critical amidst growing populations and other emerging challenges for the $300 billion global crop market. Traditional crossbreeding of plants for desirable phenotypic traits is being improved by genetic marker assisted selection (MAS), where known genetic markers associated with...

Published: 6/27/2024 | Inventor(s): Tza-Huei Wang, Kuangwen Hsieh, Helena Zec, Lingshu Liu, Aniruddha Kaushik, Yue Yun

Keywords(s): Assay, Clinical Diagnostics, Crop Management, In Vitro Diagnostics, Microfluidic, Operations Management

Category(s): Technology Classifications > Industrial Tech > Agriculture, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Diagnostics, Technology Classifications > Industrial Tech, Technology Classifications > Research Tools, Technology Classifications > Engineering Tech > Agriculture

High-throughput microfluidic platform for high-density immobilization and parallelized quantitative real-time measurements of droplets

Unmet Need:Droplet platforms, which compartmentalize samples into encapsulated droplets for high-throughput analysis, have been used to detect and analyze diverse molecules, including nucleic acids, proteins, and single cells, at a higher sensitivity than traditional methods. Despite advantages in sensitivity and throughput, most existing droplet analysis...

Published: 6/28/2024 | Inventor(s): Tza-Huei Wang, Christine O'Keefe, Aniruddha Kaushik

Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics (Old), In Vitro Research Tool, Microfluidic, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays

Streamlined Platform for Bacterial Identification and Antimicrobial Susceptibility Test

Unmet NeedFor managing dangerous infections, clinicians need to know what bacteria strain(s) is/are causing the infections, the bacterial loads, and the antibiotic resistance profile of the bacteria. Without knowing this vital information in a timely manner, it is impossible to begin using narrow-spectrum antibiotics that can effectively treat the...

Published: 6/27/2024 | Inventor(s): Tza-Huei Wang, Pornpat Athamanolap, Liben Chen, Kuangwen Hsieh

Keywords(s): Assay, Bacterial Infections, Clinical Diagnostics, Diagnostic Tool, Disease Indication, In Vitro Diagnostics, Measurement Tool, Microfluidic

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Parallelization of Fission and Fusion Operations for High Throughput Generation of Combinatorial Droplets

Recent research in digital microfluidics has burgeoned as droplets can function as miniaturized reactors in biological and chemical applications. Droplet microfluidic platforms boast the ability to generate many reactions within short time periods. However, most droplet platforms digitize samples into discrete droplets and are limited to the analysis...

Published: 6/27/2024 | Inventor(s): Helena Zec, Tushar Rane, Tza-Huei Wang

Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Microfluidic, Target-based Screening Tool

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Microfluidics

Multiplexed Screening of a Large Library of Biological Samples Through On-demand Droplet Generation and Fusion

A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection...

Published: 6/27/2024 | Inventor(s): Tushar Rane, Wen-Chy Chu, Helena Zec, Tza-Huei Wang

Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Microfluidic, Target-based Screening Tool

Microfluidic Settling Velocity Based Separation of Synthetic and Biological Particles

Novel Microfluidic Blood Fractionation DeviceJHU REF: [C11659]Invention novelty: Separation of components of blood by microfluidic device without damaging its morphology. Value PropositionThe proposed invention possesses several advantages over the current technologies employed for blood fractionation as follows: Reduction in infrastructure costs and...

Published: 6/27/2024 | Inventor(s): Chengxun Liu, German Drazer, Liesbet Lagae, Jorge Bernate

Keywords(s): Clinical Diagnostics, In Vitro Diagnostics, Sample Prep Method

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Specimen Handling, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Microfluidics

Microfluidic Solution for High-throughput, Droplet-based Single Molecule Analysis with Low Reagent Consumption

A microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with...

Published: 6/27/2024 | Inventor(s): Christopher Puleo, Kelvin Liu, Tushar Rane, Tza-Huei Wang

Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Microfluidic, Research Instrument

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Microfluidics

Microfluidic Device for High-throughput Cellular Gradient and Dose Response Studies

C04813: Microfluidic Device for High-throughput Cellular Gradient and Dose Response Studies Technical Details: This invention is a microfluidic device made of a silicone elastomer (PDMS) that can be used for dose response, gradient detection, and chemostatic growth studies of most cell types, particularly non-adherent cells. The gradient is generated...

Published: 6/27/2024 | Inventor(s): Alexander Groisman, Andre Levchenko, Saurabh Paliwal

Keywords(s): Assay, Basic Research Biomarker, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Microfluidic, Research Instrument

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Microfluidics