Search Results - xingchi+he

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Intra/Inter-Molecular Hydrogen Bonding Stabilized, Amino Acid/peptide Modified Redox-active Sorbents for Electrochemical Carbon Dioxide Separation

High Affinity, Redox-Active Sorbents for Electrochemical Carbon Capture JHU Ref #: C17628 Unmet Need In recent years, global carbon emissions have increased dramatically. Even with renewable energy sources, carbon capture is seen as the only practical method to reduce industrial emissions to meet short term criteria for preventing global warming....

Published: 6/28/2024 | Inventor(s): Yayuan Liu, Xing Li

Keywords(s):

Category(s): Technology Classifications > Industrial Tech, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Engineering Tech > Energy, Infrastructure & Environment, Technology Classifications > Engineering Tech > Industrial Manufacturing, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Industrial Tech > Materials, Technology Classifications > Engineering Tech

Delayed Lagging Strand Synthesis Promotes Male Fertility during Aging

Inhibition-based Method for Stem Cells Induction from Non-Stem Cells Value Proposition:· Induces stem cells from non-stem cells through modification of gene expression or function. · Relies on influencing a single DNA replication component rather than multiple molecular factors.· Successfully rescues both male and female fertility in...

Published: 6/28/2024 | Inventor(s): Xin Chen, Brendon Davis, Rajesh Ranjan

Keywords(s):

Category(s): Clinical and Disease Specializations > Reproductive Health > Fertility, Clinical and Disease Specializations > Wound Healing

Large-scale Epigenomic Reprogramming Links Anabolic Glucose Metabolism to Distant Metastasis during the Evolution of Pancreatic Cancer Progression

Unmet NeedPancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer death in the western world by 2020. Subclonal populations that emerge and drive metastatic progression of the disease are associated with high mortality rates among patients. Blocking the tumorigenic potential of metastatic sites is key to improving...

Published: 6/27/2024 | Inventor(s): Andrew Feinberg, Xin Li, Christine Iacobuzio-Donahue, Oliver McDonald

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Pancreatic Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer

A Sensorized Ophthalmic Endo-illuminator for Intraocular Surgery

Unmet Need Lack of force sensing is one of the most formidable technical challenges in retinal microsurgery. Incorporating high sensitivity force sensing into the ophthalmic tools has the potential to provide the surgeon useful force feedback and to enable safe robotic assistance. Forces exerted in retinal microsurgery are generally well below the...

Published: 6/27/2024 | Inventor(s): Iulian Iordachita, Xingchi He, Yuki Horise, Russell Taylor, Peter Gehlbach

Keywords(s): Disease Indication, Eye Disorders, Interventional and Surgical Systems, Probes, Surgical Instruments

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices

Discovery of 2,6-Dimethoxy-4-(5-Phenyl-4-Thiophen-2-yl-1H-Imidazol-2-yl)-Phenol (DPTIP) a Small Molecule Inhibitor of Neutral Sphingomyelinase 2 (nSMase2) for the Treatment of Neurodegenerative and Oncologic Diseases

Unmet NeedAlzheimer’s disease (AD) is the most common form of dementia, affecting approximately 5.7 million people in the United States in 2018. Yet, no cure exists for AD, and AD therapeutics presently on the market fail to treat the disease’s underlying causes. Recent studies in mice reveal that exosomes released from glial cells contribute to the...

Published: 6/27/2024 | Inventor(s): Barbara Slusher, Camilo Rojas, Ajit Thomas, Norman Haughey, Marc Ferrer, Xin Hu

Keywords(s): Antagonists/Inhibitors, Cancers, CNS and Neurological Disorders, Disease Indication, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules

A Miniaturized Triaxial Force Sensor with Independent Axial and Transverse Force Sensing

Unmet Need Lack of force sensing is one of the most formidable technical challenges in retinal microsurgery. Incorporating high sensitivity force sensing into the ophthalmic tools has thepotential to provide the surgeon useful force feedback and to enable safe robotic assistance. Forces exerted in retinal microsurgery are generally well below the human...

Published: 6/27/2024 | Inventor(s): Iulian Iordachita, Xingchi He, Russell Taylor, James Handa, Peter Gehlbach

Keywords(s): Disease Indication, Eye Disorders, Interventional and Surgical Systems, Robotic Surgical System Sensing, Surgical Navigation

Category(s): Technology Classifications > Computers, Electronics & Software > Robotics, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Ophthalmology

Miniature Dexterous Manipulator for Therapeutic and Diagnostic Procedures in the Clinical Setting where Tool Access is Limited

Unmet Need: Next-generation surgical tools.Technology Overview: The technology is a dexterous manipulator less than 1 mm in diameter and 3 mm in length. It can be used as a procedural platform that can access narrow, tight, constrained or otherwise inaccessible spaces in the body in order to provide high dexterity that permits: the performance of...

Published: 6/27/2024 | Inventor(s): Xingchi He, Vincent Van Geirt, Peter Gehlbach, Russell Taylor, Iulian Iordachita

Keywords(s): Interventional and Surgical Systems, Surgical Instruments

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices

Radiolabeled Triazole Conjugated Ureas (YC-88)

Prostate-specific membrane antigen (PSMA) is a type II integral membrane protein expressed on the surface of prostate tumors, particularly in castrate-resistant, advanced and metastatic disease. PSMA is also expressed in neovascular endothelium of most solid tumors, such as lung, colon, pancreatic, renal carcinoma and skin melanoma, but not in normal...

Published: 6/27/2024 | Inventor(s): Martin Pomper, Ronnie Mease, Ying Chen, Sangeeta Ray, Xing Yang

Keywords(s): Antagonists/Inhibitors, Cancers, Discovery/Research Tools, Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Labels/Markers, Novel, Predicted Novelty, Research Reagent, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics > Diagnostic Imaging

Salicylic Acid-based Polymeric CEST Contrast Agents for Molecular Imaging of Prostate-specific Membrane Antigen

We have discovered that a salicylic acid (SA) analog when grafted on a polymeric platform is able to produce significantly enhanced contrast in MR images detectable through chemical exchange saturation transfer (CEST). That SA modified polymeric platform (SA PolyCEST), has been further modified with Glu-Lysine urea, an inhibitor of Prostate-specific...

Published: 6/27/2024 | Inventor(s): Xing Yang, Michael Mcmahon, Sangeeta Ray, Xiaolei Song, Martin Pomper

Keywords(s): Cancers, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

New Scaffolds and Multifunctional Intermediates for Imaging PSMA

The prostate-specific membrane antigen (PSMA) is increasingly recognized as an important target for cancer imaging and therapy. Current PSMA inhibitors based on a urea scaffold have shown good results for imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) in human subjects. The urea scaffold has...

Published: 6/27/2024 | Inventor(s): Martin Pomper, Ying Chen, Sangeeta Ray, Ronnie Mease, Xing Yang, Georgio Attardo

Keywords(s): Cancers, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Positron Emission Tomography (PET), Prostate Cancer

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