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Nanofiber Nerve Cuffs to Inhibit Neuroma Formation

Nanofiber Nerve Cuff to Inhibit Neuroma FormationJHU Ref #: [C17593]Value Proposition:· This device can be used to cap the end of a severed nerve to prevent unwanted nerve growth through a combination of physical and biochemical mechanisms.· This device is more effective than existing nerve caps and cuffs, due to the inclusion of bioactive...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Ahmet Hoke, Anson Zhou, Bruce Enzmann, Michael Lan, Erica Lee, Ruifa Mi, Russell Martin

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic Devices

Method to Inhibit Toxic Pathways Activated in Genetic ALS/FTD

Value PropositionTreatment readily acts via subcutaneous injection and crosses the blood-brain barrier without extra formulation or drug delivery mechanism.Treatment significantly reduces pathological and behavioral phenotypes from toxic proteins coded by genetic defects in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which...

Published: 3/14/2025 | Inventor(s): Shuying Sun, Zhe Zhang

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Motor Neuron Diseases, Clinical and Disease Specializations > Neurology > Dementia, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics > Biomarkers

Epigenetic Changes in Sperm are Associated with Paternal and Child Quantitative Autistic Traits in an Autism-enriched Cohort

Value Proposition· Predictive Power: Provides an early non-invasive method to assess an offspring’s risk of autism before birth using paternal semen· Personalized Insight: Adapts risk prediction to individual genetic and epigenetic profiles· Environmental Sensitivity: Accounts for the impact of environmental factors on ASD risk· Platform-Agnostic:...

Published: 3/14/2025 | Inventor(s): Andrew Feinberg, Heather Volk, Jason Feinberg, Rose Schrott

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Category(s): Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology

18F-Labeled PET Radiotracers for Imaging Neuroinflammation in the Brain

Value Proposition:· Quantification and PET imaging of microglial cells in the brain· Diagnostic for neuroinflammatory disorders – Alzheimer’s and MS· Favorable compound half-life enables shipping· Potential for non-CNS applications Technology DescriptionResearchers at Johns Hopkins have developed a series of Positron Emission Tomography...

Published: 3/14/2025 | Inventor(s): Martin Pomper, Deepankar Das, Andrew Horti, Wojciech Lesniak

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

Discovery of Small Molecule Inhibitors of Neutral Sphingomyelinase 2 (nSMase2) for the Treatment of Neurodegenerative Diseases

Unmet NeedIn the brain, neutral sphingomyelinase 2 (nSMase2) is expressed in neurons and increased activity and expression of this enzyme has been associated with pro-inflammatory conditions observed in Alzheimer’s disease, multiple sclerosis and human immunodeficiency virus (HIV-1) patients. Inhibition of human nSMase2 may preserve neuronal function...

Published: 3/13/2025 | Inventor(s): Barbara Slusher, Camilo Rojas, Ajit Thomas, Radim Nencka, Michal Sala, Hubert Hrebabecky, Norman Haughey

Keywords(s): Alzheimer's Disease, Antagonists/Inhibitors, Assay, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Non-novel, Off-the-shelf, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease

Diagnostic and therapeutic target for primary dysautonomia

Value Proposition:· Diagnostic target for broad primary dysautonomia screening.· Broadly applicable therapeutic target for symptom relief in primary and secondary dysautonomia patients.Technology DescriptionResearchers at Johns Hopkins have identified a potential diagnostic and therapeutic target for patients with primary dysautonomia....

Published: 3/14/2025 | Inventor(s): Malcolm Brock, Frank Bosmans

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Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities > Small Molecules

Gene therapy for SYNGAP1 encephalopathy and SYNGAP1-related disorders

Unmet Need: SYNGAP1-related Intellectual Disability (SRID, MRD5) is a severe neurodevelopmental disorder (NDD) characterized by encephalopathy, intellectual disability (ID), autism spectrum disorder (ASD), and epilepsy and accounts for 0.5-1% of all NDDs and ~1% of the ~200 million ID cases worldwide (SYNGAP Research Fund, 2020). Supportive management...

Published: 3/14/2025 | Inventor(s): Richard Huganir, Ingie Hong, Yoichi Araki, Richard Johnson

Keywords(s):

Category(s): Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Gene Therapies

Cell-Permeable Protein Therapeutic for Pain and Itch

Novelty:Identification of a mutant peptide with strong inhibitory effect on nociceptor TRPA1, useful for the prevention and treatment of chronic and acute pain and itch.Value Proposition:Dysregulation of ion channels is associated with various debilitating conditions, including chronic pain and itch. Transient receptor potential ankyrin 1 (TRPA1), an...

Published: 3/13/2025 | Inventor(s): Hao-Jui Weng, Xinzhong Dong

Keywords(s): Biologics, Biomarker, Chronic Pain, CNS and Neurological Disorders, Disease Indication, Mechanism of Action Biomarker, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Pain > Chronic Pain

DOPA and Caffeic Acid Analogs as Novel GCPII Inhibitors

Unmet NeedGlutamate is the primary excitatory neurotransmitter in the human brain [1]. Excessive glutamate signaling can disrupt calcium homeostasis, leading to mitochondrial dysfunction, the overproduction of reactive oxygen species, and neuron loss via necrotic or apoptotic pathways [2]. This phenomenon, known as excitotoxicity, contributes to disease...

Published: 3/14/2025 | Inventor(s): Barbara Slusher, Rana Rais, Takashi Tsukamoto

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Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules

Controlling homeostatic regulatory circuitry in hypothalamus

Value Proposition· Identifies targets for modulation of tanycyte-derived neurogenesis.· Demonstrates efficacy of small molecule induction of tanycyte-derived neurogenesis.· Combines viral constructs and small molecules to generate specific subtypes of tanycyte-derived neurons.· Applicable to a broad range of hypothalamic...

Published: 3/14/2025 | Inventor(s): Seth Blackshaw, Sooyeon Yoo, Leighton Duncan

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Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Stem Cells

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