Search Results - clinical+and+disease+specializations+%3e+neurology

157 Results

Sort By:

GluR2 Y876F mouse line

Unmet Need:The ability of neurons to alter the strength of their synaptic inputs bidirectionally in response to different stimuli is known as synaptic plasticity. Synaptic plasticity allows the brain to encode and respond to different stimuli such as learning and memory. Synaptic strengthening and weakening are finely tuned by changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic...

Published: 3/13/2026 | Inventor(s): Richard Huganir

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology

bio-IB3

Unmet NeedAccording to the CDC, approximately 5.8-million individuals aged 65+ in the United States were living with Alzheimer’s disease in 2020 (see CDC). Alzheimer’s disease leads to memory impairment that progressively affects the ability of individuals to conduct daily tasks and worsens with time. Currently, the diagnosis of Alzheimer’s disease...

Published: 3/12/2026 | Inventor(s): Esther Oh, Stina Tucker, David Borchelt, Juan Troncoso

Keywords(s): Alzheimer's Disease, Antibodies, Biologics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Neurodegeneration, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration

A Machine Learning Framework for Tagged MRI Analysis

Value Proposition: The BRITE framework operates on tagged MRI data to significantly improve the accuracy and efficiency of evaluating motion and strain in tissues. This advancement enables clinicians to make more informed decisions regarding patient care, particularly in diagnosing cardiovascular conditions and analyzing brain mechanics, ultimately...

Published: 3/13/2026 | Inventor(s): Zhangxing Bian, Jerry Prince, Shuwen Wei, Ahmed Alshareef, Jiachen Zhuo

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

Human LRRK2 cDNA

Studies have shown that mutations in the LRRK2 gene are the most common determinants of late-onset Parkinsons disease (PD) susceptibility. These cDNA vectors comprise wild type LRRK2 cDNA or mutated LRRK2 cDNA that can be expressed in cells to decipher the biochemical pathways and pathology of PD. Other advantages include:• Produced from human source...

Published: 3/12/2026 | Inventor(s): Ted Dawson

Keywords(s): Basic Research Biomarker, Cloning Reagents, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Nucleotide, Parkinson's Disease, Research Reagent

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Immortalized Human DRG Neuronal Cell Line

Unmet NeedPeripheral neuropathy is estimated to affect 20 million people in the U.S. alone. Patients suffer from a number of symptoms including: numbness, tingling, pricking sensations, muscle weakness, abnormal sensitivity to touch, and feelings of burning pain. Two of the most common causes of peripheral neuropathy are the result of diabetes and toxicity...

Published: 3/13/2026 | Inventor(s): Ahmet Hoke, Weiran Chen, Gabsang Lee

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Stem Cells

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Stem Cells

Intra-operative Orthognathic Biomechanical Simulation

Value Proposition· Real-Time Operation Adjustments: The system provides live 3D positioning updates of the donor and recipient anatomies, allowing for instant feedback for surgeons. · Mastication Simulation: The technology spontaneously identifies ideal positioning of the donor face to allow for optimal recipient mastication post-op.· Mid-Surgery...

Published: 3/12/2026 | Inventor(s): Ryan Murphy, Mehran Armand, Peter Liacouras, Gerald Grant, Chad Gordon, Ehsan Basafa

Keywords(s): Integrated Imaging System, Interventional and Surgical Systems, Surgical Navigation

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Surgery, Applied Physics Laboratory > Applied Physics Laboratory, Clinical and Disease Specializations > Transplantation, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Plastic Surgery, Technology Classifications, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Traumatic Injury > Craniomaxillofacial Trauma

GsMtx-4 as a Treatment of Schwannomatosis Induced Pain

Value Proposition:· First Non-Surgical Therapy for Schwannomatosis Pain: Introduces the first targeted, injectable, mechanism-based treatment for schwannoma-associated pain, replacing the current reliance on tumor resection for pain control.· Mechanosensitive Ion Channel (MSC) Inhibition: GsMTx-4 uniquely blocks mechanosensitive ion channels...

Published: 3/13/2026 | Inventor(s): Kimberly Ostrow

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Neuropathy, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Neuropathic Pain, Clinical and Disease Specializations > Neurology > Hyperalgesia, Technology Classifications > Therapeutic Modalities > Peptides

Smart Phantom for Neurosurgical Training and Evaluation

Value Proposition:· Provides a realistic, low-risk training alternative to patient-based neurosurgery education, ultimately improving patient safety and clinical outcomes.· Offers a flexible, patient-specific training platform that can replicate both normal and pathological anatomy using CT scan data.· Features an optical measurement...

Published: 3/13/2026 | Inventor(s): Peter Kazanzides, Ehsan Azimi, Zhiyuan Niu

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Computers, Electronics & Software > Robotics

A Method to Conditionally Deliver Effector Proteins to Plasma and Endosomal Membranes in Response to Tyrosine Kinase Signaling

Value Proposition· Effective & Targeted: Harnesses endogenous pain signaling via receptor tyrosine kinases to conditionally deliver effector proteins to the plasma membrane, enabling suppression of chronic pain under pathological conditions· Broadly Applicable: Enables modular, tunable therapy tailored to the prevailing pathological...

Published: 3/13/2026 | Inventor(s): Michael Caterina, Stephen Gould, Shang-Jui Tsai

Keywords(s):

Category(s): Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Therapeutic Modalities > Proteins, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology

Nanofiber Nerve Cuffs to Inhibit Neuroma Formation

JHU Ref #: C17593Value Proposition:· This device can be used to cap the end of a severed nerve to prevent unwanted nerve growth through a combination of physical and biochemical mechanisms.· This device is more effective than existing nerve caps and cuffs, due to the inclusion of bioactive agents that biochemically influence nerve growth.Technology...

Published: 3/13/2026 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Ahmet Hoke, Anson Zhou, Bruce Enzmann, Michael Lan, Erica Lee, Ruifa Mi, Russell Martin

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic Devices

1 2 3 4 5 6 7 8 9 10 ...