Search Results - clinical+and+disease+specializations+%3e+neurology

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Multi-Region Brain Organoids (MRBOs)A TechBio platform that pairs the most physiologically faithful human brain tissue with AI-driven computational genomics to generate proprietary CNS drug discovery insights no other system can produce.The ProblemCNS drug development has the highest failure rate of any therapeutic area, and the root cause is computational,...

Published: 4/24/2026 | Inventor(s): Annie Kathuria

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Research Tools

Cell-type specific technique for neuron projection mapping

Value Proposition• Able to target specific populations of neurons in connectome profiling • High-throughput projection mapping at the single-neuron level• Can discriminate molecular or connectomic cell types among targeted neurons• Sequencing-based approach enables fast and accurate results Unmet NeedUnderstanding the mechanisms by which neurons establish...

Published: 4/24/2026 | Inventor(s): Justus Kebschull, Hyopil Kim, Huihui Qi

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Bioinformatics

GluA2 Y876F Transgenic Mouse Model

Unmet Need:The ability of neurons to alter the strength of their synaptic inputs bidirectionally in response to different stimuli is known as synaptic plasticity. Synaptic plasticity allows the brain to encode and respond to different stimuli such as learning and memory. Synaptic strengthening and weakening are finely tuned by changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic...

Published: 4/24/2026 | Inventor(s): Richard Huganir

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology

A Machine Learning Framework for Tagged MRI Analysis

Value Proposition: The BRITE framework operates on tagged MRI data to significantly improve the accuracy and efficiency of evaluating motion and strain in tissues. This advancement enables clinicians to make more informed decisions regarding patient care, particularly in diagnosing cardiovascular conditions and analyzing brain mechanics, ultimately...

Published: 4/24/2026 | Inventor(s): Zhangxing Bian, Jerry Prince, Shuwen Wei, Ahmed Alshareef, Jiachen Zhuo

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

Leucine-Rich Repeat Kinase 2 (LRRK2) cDNA Vectors Research Reagent

Studies have shown that mutations in the LRRK2 gene are the most common determinants of late-onset Parkinsons disease (PD) susceptibility. These cDNA vectors comprise wild type LRRK2 cDNA or mutated LRRK2 cDNA that can be expressed in cells to decipher the biochemical pathways and pathology of PD. Other advantages include:• Produced from human source...

Published: 4/23/2026 | Inventor(s): Ted Dawson

Keywords(s): Basic Research Biomarker, Cloning Reagents, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Nucleotide, Parkinson's Disease, Research Reagent

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Immortalized Human DRG Neuronal Cell Line

Unmet NeedPeripheral neuropathy is estimated to affect 20 million people in the U.S. alone. Patients suffer from a number of symptoms including: numbness, tingling, pricking sensations, muscle weakness, abnormal sensitivity to touch, and feelings of burning pain. Two of the most common causes of peripheral neuropathy are the result of diabetes and toxicity...

Published: 4/24/2026 | Inventor(s): Ahmet Hoke, Weiran Chen, Gabsang Lee

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Stem Cells

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Stem Cells

3D Live Modeling of Facial Transplantation Surgery to Maximize Patient Outcomes

Value Proposition· Real-Time Operation Adjustments: The system provides live 3D positioning updates of the donor and recipient anatomies, allowing for instant feedback for surgeons. · Mastication Simulation: The technology spontaneously identifies ideal positioning of the donor face to allow for optimal recipient mastication post-op.· Mid-Surgery...

Published: 4/23/2026 | Inventor(s): Ryan Murphy, Mehran Armand, Peter Liacouras, Gerald Grant, Chad Gordon, Ehsan Basafa

Keywords(s): Integrated Imaging System, Interventional and Surgical Systems, Surgical Navigation

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Surgery, Applied Physics Laboratory > Applied Physics Laboratory, Clinical and Disease Specializations > Transplantation, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Plastic Surgery, Technology Classifications, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Traumatic Injury > Craniomaxillofacial Trauma

GsMTx-4 as a Treatment for Schwannomatosis-Induced Pain

Value Proposition:· First Non-Surgical Therapy for Schwannomatosis Pain: Introduces the first targeted, injectable, mechanism-based treatment for schwannoma-associated pain, replacing the current reliance on tumor resection for pain control.· Mechanosensitive Ion Channel (MSC) Inhibition: GsMTx-4 uniquely blocks mechanosensitive ion channels...

Published: 4/24/2026 | Inventor(s): Kimberly Ostrow

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Neuropathy, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Neuropathic Pain, Clinical and Disease Specializations > Neurology > Hyperalgesia, Technology Classifications > Therapeutic Modalities > Peptides

Smart Phantom for Neurosurgical Training and Evaluation

Value Proposition:· Provides a realistic, low-risk training alternative to patient-based neurosurgery education, ultimately improving patient safety and clinical outcomes.· Offers a flexible, patient-specific training platform that can replicate both normal and pathological anatomy using CT scan data.· Features an optical measurement...

Published: 4/24/2026 | Inventor(s): Peter Kazanzides, Ehsan Azimi, Zhiyuan Niu

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Computers, Electronics & Software > Robotics

A method to conditionally deliver effector proteins to plasma and endosomal membranes to treat chronic pain

Value Proposition· Effective & Targeted: Harnesses endogenous pain signaling via receptor tyrosine kinases to conditionally deliver effector proteins to the plasma membrane, enabling suppression of chronic pain under pathological conditions· Broadly Applicable: Enables modular, tunable therapy tailored to the prevailing pathological...

Published: 4/24/2026 | Inventor(s): Michael Caterina, Stephen Gould, Shang-Jui Tsai

Keywords(s):

Category(s): Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Therapeutic Modalities > Proteins, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology

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