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A Transgenic Mouse Line for Ablating Cells Positive for Opn4 Expression
TITLE A Transgenic Mouse Line for Ablating Cells Positive for Opn4 Expression CASE NUMBER: C17059 ABSTRACT Rod and cone photoreceptors detect light and relay this information through a multisynaptic pathway to the brain via retinal ganglion cells (RGCs). These retinal outputs support not only...
Published: 3/27/2026   |   Inventor(s): Samer Hattar
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools
GluA2 Y876F Transgenic Mouse Model
Unmet Need:The ability of neurons to alter the strength of their synaptic inputs bidirectionally in response to different stimuli is known as synaptic plasticity. Synaptic plasticity allows the brain to encode and respond to different stimuli such as learning and memory. Synaptic strengthening and weakening are finely tuned by changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic...
Published: 3/27/2026   |   Inventor(s): Richard Huganir
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology
System for Mapping the Fate of Post-Hypoxic Cells In Vivo and In Vitro
Value Proposition·        Permanently labels cells that have experienced hypoxia, enabling long-term tracking·        Captures tumor evolution by identifying cells with past hypoxia exposure, not just at the time of tissue collection·        Enables investigation of metastasis by tracking cells from hypoxic niches that may retain aggressive phenotypes·        Supports...
Published: 3/27/2026   |   Inventor(s): Daniele Gilkes, Ines Godet
Keywords(s): Breast Cancer, Cancers, Cardiovascular Diseases, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, In Vivo Research Tool, Mouse Model, Translational Research Biomarker
Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines
NK1-Cre mice
Invention novelty: Project neurons in the spinal cord play essential role in transmitting and modulating pain and itch signals from the periphery. NK1 is the receptor of the major pain and itch neurotransmitter peptide substance P. NK1 is expressed in the project neurons in the dorsal horn of the spinal cord. Dysfunction of these neurons often leads...
Published: 3/27/2026   |   Inventor(s): Xinzhong Dong
Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools
Tamoxifen-Inducible Mouse Model for Enhanced Labeling of Tyrosine Hydroxylase-Expressing Neurons
Value Proposition·      Enhanced labeling efficiency: The TH-2A-CreER mouse line achieves higher labeling efficiency compared to existing mouse lines through the 2A peptide system that ensures elevated CreER expression levels·      Multi-population targeting: Enables labeling and functional manipulation of TH-expressing neuronal populations including...
Published: 3/27/2026   |   Inventor(s): David Ginty
Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools
Mechanistic insights reveal drug discovery target for lithium responders and non-responders
Value PropositionNew mouse model for mood switching behavior with viability for compound screeningDemonstrated that BK channels in excitatory neurons are involved in cellular pathology of patients by affecting Ca2+ kineticsApplication to both lithium responders and non-responders Unmet NeedBipolar disorder (BPD) has a lifetime prevalence of 4-5% in...
Published: 3/27/2026   |   Inventor(s): Akira Sawa, Rupali Srivastava, Koko Ishizuka
Keywords(s):  
Category(s): Clinical and Disease Specializations > Psychiatry > Bipolar Disorder, Clinical and Disease Specializations > Psychiatry > Mood Disorders, Clinical and Disease Specializations > Psychiatry > Suicidal Impulses, Technology Classifications > Research Tools > Animal Models
Mouse Model for Life-Threatening Pediatric Diarrhea
Value PropositionFirst infantile diarrhea model to capture host immune responses to enteric bacterial infections.Exhibits symptoms for lethal and severe infantile enteropathogenic E. coli infection episodes.Allows for discovery and screening of novel drug targets for E. coli infection-associated lethal diarrhea in infantsUnmet NeedThe WHO Global Burden...
Published: 3/27/2026   |   Inventor(s): Fengyi Wan
Keywords(s):  
Category(s): Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Research Tools > Animal Models
SYNGAP1 Mouse Models
Unmet NeedIt is estimated that there are 177 million people in the world affected by non-syndromic intellectual disability and of that group 1% (or 1.77 million people) have a mutation in the SYNGAP1 gene (see SynGAP Research Fund). The SYNGAP1 gene is essential for mental health, and it is known that mutations in the gene lead to severe intellectual...
Published: 3/27/2026   |   Inventor(s): Richard Huganir
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models
Col3a1G209S heterozygous mice
Unmet Need:Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder. Patients with vEDS present with thin, translucent skin, easy bruising, and a characteristic facial appearance. Most critically, they are at risk for spontaneous rupture of the major arteries, hollow organs, and gravid uterus. Preclinical investigation of...
Published: 3/27/2026   |   Inventor(s): Harry Dietz, Caitlin Bowen, Juan Calderon Giadrosic, Mark Helmers
Keywords(s):  
Category(s): Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models
Col3a1G938D heterozygous mice
Unmet Need:Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder. Patients with vEDS present with thin, translucent skin, easy bruising, and a characteristic facial appearance. Most critically, they are at risk for spontaneous rupture of the major arteries, hollow organs, and gravid uterus. Preclinical investigation of...
Published: 3/27/2026   |   Inventor(s): Harry Dietz, Caitlin Bowen
Keywords(s):  
Category(s): Clinical and Disease Specializations > Genetic Diseases, Technology Classifications, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models
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