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Device and Methods for Engineering 3D Complex Tissues

Value Proposition· Precise: Enables precise engineering of complex 3D tissue structures using aligned cell sheets and thermoresponsive scaffolds· Buildable: “tissue origami” platform allows folding, molding, and positioning of tissues in geometrically complex configurations· Flexible: Superior cell sheet detachment via flexible substrate...

Published: 9/12/2025 | Inventor(s): Deok-Ho Kim, Nisa Williams, Alex Jiao

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Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Medical Devices > Regenerative Medicine

Kinetically controlled methods to prepare concentrated shelf-stable nucleic acid transfection vehicles

Value Proposition:· Technology creates particles optimally size for use as vehicles for cell transfection.· The reagents and processes for particle creation are kinetically controlled and reproducible.· Cationic particles created using these methods can carry larger payloads than current vehicles.· Reagents and nucleic acid-loaded...

Published: 9/12/2025 | Inventor(s): Hai-Quan Mao, Yizong Hu, Jinghan Lin

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Extracellular Vesicle‐based Agents and Methods for the Treatment of Neuropathic Disorders

Unmet Need:Human induced pluripotent stem cells (hiPSCs), and neurons differentiated from them, have been a powerful tool for modeling neuronal pathophysiologies and preclinical efficacy/toxicity screening of novel therapeutic compounds. However, these cells cultured in vitro typically do not fully recapitulate the physiology of the human nervous system,...

Published: 9/12/2025 | Inventor(s): Deok-Ho Kim, Alec Smith, Changho Chun, Minjae Do

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Category(s): Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Cell Lines

K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells

C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...

Published: 9/11/2025 | Inventor(s): Ben Ho Park

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Glucocerebrosidase 1 (GBA1) Knockout SH-SY5Y Cell Line

JHU Ref #: C18058 Value Proposition:GBA1 knockout SH-SY5Y human neuroblastoma cell lineGenerated using CRISPR/Cas9 KO technologyUnavailable from any other sourceNo observable off-target effectsUnmet Need:It has been demonstrated that GBA1 deficiency contributes to the aggregation of α-synuclein (α-syn) and the transition from monomeric α-syn to α-syn...

Published: 9/12/2025 | Inventor(s): Han Seok Ko

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Category(s): Clinical and Disease Specializations > Neurology > Parkinson’s Disease, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines

Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 9/11/2025 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Cell Lines with Inducible LINE-1

Unmet NeedIn the United States, approximately 1.9-million new cancer cases are projected to be diagnosed with 608,570 cancer deaths in 2021 (see ACS). Early screening initiatives that detect cancer as well as novel therapeutics that target and destroy tumor cells may lead to a future decrease in the number of cancer-related mortality. To improve the...

Published: 9/12/2025 | Inventor(s): Kathleen Burns, Andrew Holland, Daniel Ardeljan

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Category(s): Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology

Multi-Compartment Fallopian Tube Organoid Model

Unmet Need: Existing organoid models of the fallopian tube are architecturally simplified compared to the intricate epithelial-lumen interface in scale and structure, and there remains a need in the art for multi-compartment fallopian tube organoids that architecturally simulate the intricate architecture of the epithelial-lumen interface in structural...

Published: 9/12/2025 | Inventor(s): Meng Horng Lee, Gabriella Russo, Denis Wirtz, Ashleigh Crawford, Wenxuan Du

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Category(s): Technology Classifications, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Stem Cells, Technology Classifications > Research Tools > Microfluidics, Clinical and Disease Specializations > Oncology

Inducible OGT Knockout Cell Line

Marketing Summary DraftInducible OGT Knock-out Cell LineJHU Ref #: C17974Value Proposition· Mouse embryonic fibroblast cell line· Rapid and reproducible depletion of essential OGT gene· Enables O-GlcNAc modification studiesUnmet Need· O-GlcNAcylation (O-GlcNAc) is a nutrient- and stress-responsive post-translational modification...

Published: 9/12/2025 | Inventor(s): Natasha Zachara, Hana Chang, Michael Wolfgang, Zahra Kazemi

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Category(s): Technology Classifications, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines

Clinical-Grade Therapeutic Progenitors Generated from Universal Donor Tankyrase/PARP-Inhibited Pluripotent Stem Cell Banks

Unmet Need / Invention Novelty: Regenerative cell therapies with conventional, lineage-primed human induced pluripotent stem cells (hiPSC) are limited by variable differentiation efficiency and poor in vivo functionality. There is an unmet need to establish novel methods for efficiently generating functional and transplantable therapeutic progenitors. Technical...

Published: 9/12/2025 | Inventor(s): Elias Zambidis, Ludovic Zimmerlin

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Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Research Stem Cells

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