Search Results - technology+classifications+%3e+research+tools+%3e+cell+lines

183 Results

Sort By:

A Novel-fate Marking Strategy to Permanently Tag Hypoxic Cancer Cells

Value Proposition· Permanently labels cells that have experienced hypoxia, enabling long-term tracking· Captures tumor evolution by identifying cells with past hypoxia exposure, not just at the time of tissue collection· Enables investigation of metastasis by tracking cells from hypoxic niches that may retain aggressive phenotypes· Supports...

Published: 1/22/2026 | Inventor(s): Daniele Gilkes, Ines Godet

Keywords(s): Breast Cancer, Cancers, Cardiovascular Diseases, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, In Vivo Research Tool, Mouse Model, Translational Research Biomarker

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines

Muscular Dystrophy Cell Lines

Unmet NeedFacioscapulohumeral muscular dystrophy (FSHD) is a complex neuromuscular disorder affecting 1 in 20,000 individuals. The disease is characterized by progressive wasting of facial, upper arm and shoulder girdle muscles. FSHD has variable age of onset, ranging from infant to late adult; and approximately one-third of patients lose the ability...

Published: 1/22/2026 | Inventor(s): Kathryn Wagner

Keywords(s): Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Muscular Dystrophy

Category(s): Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Musculoskeletal > Muscle Atrophy

TH-2A-CreER Mice

Value Proposition· Enhanced labeling efficiency: The TH-2A-CreER mouse line achieves higher labeling efficiency compared to existing mouse lines through the 2A peptide system that ensures elevated CreER expression levels· Multi-population targeting: Enables labeling and functional manipulation of TH-expressing neuronal populations including...

Published: 1/22/2026 | Inventor(s): David Ginty

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Device and Methods for Engineering 3D Complex Tissues

Value Proposition· Precise: Enables precise engineering of complex 3D tissue structures using aligned cell sheets and thermoresponsive scaffolds· Buildable: “tissue origami” platform allows folding, molding, and positioning of tissues in geometrically complex configurations· Flexible: Superior cell sheet detachment via flexible substrate...

Published: 1/22/2026 | Inventor(s): Deok-Ho Kim, Nisa Williams, Alex Jiao

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Medical Devices > Regenerative Medicine

Kinetically controlled methods to prepare concentrated shelf-stable nucleic acid transfection vehicles

Value Proposition:· Technology creates particles optimally size for use as vehicles for cell transfection.· The reagents and processes for particle creation are kinetically controlled and reproducible.· Cationic particles created using these methods can carry larger payloads than current vehicles.· Reagents and nucleic acid-loaded...

Published: 1/22/2026 | Inventor(s): Hai-Quan Mao, Yizong Hu, Jinghan Lin

Keywords(s):

Extracellular Vesicle‐based Agents and Methods for the Treatment of Neuropathic Disorders

Unmet Need:Human induced pluripotent stem cells (hiPSCs), and neurons differentiated from them, have been a powerful tool for modeling neuronal pathophysiologies and preclinical efficacy/toxicity screening of novel therapeutic compounds. However, these cells cultured in vitro typically do not fully recapitulate the physiology of the human nervous system,...

Published: 1/22/2026 | Inventor(s): Deok-Ho Kim, Alec Smith, Changho Chun, Minjae Do

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Cell Lines

K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells

C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...

Published: 1/22/2026 | Inventor(s): Ben Ho Park

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Glucocerebrosidase 1 (GBA1) Knockout SH-SY5Y Cell Line

JHU Ref #: C18058 Value Proposition:GBA1 knockout SH-SY5Y human neuroblastoma cell lineGenerated using CRISPR/Cas9 KO technologyUnavailable from any other sourceNo observable off-target effectsUnmet Need:It has been demonstrated that GBA1 deficiency contributes to the aggregation of α-synuclein (α-syn) and the transition from monomeric α-syn to α-syn...

Published: 1/22/2026 | Inventor(s): Han Seok Ko

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Parkinson’s Disease, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines

Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 1/22/2026 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Cell Lines with Inducible LINE-1

Unmet NeedIn the United States, approximately 1.9-million new cancer cases are projected to be diagnosed with 608,570 cancer deaths in 2021 (see ACS). Early screening initiatives that detect cancer as well as novel therapeutics that target and destroy tumor cells may lead to a future decrease in the number of cancer-related mortality. To improve the...

Published: 1/22/2026 | Inventor(s): Kathleen Burns, Andrew Holland, Daniel Ardeljan

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology

1 2 3 4 5 6 7 8 9 10 ...