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Search Results - technology+classifications+%3e+research+tools+%3e+human+cell+lines
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K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells
C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...
Published: 3/13/2025
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Inventor(s):
Ben Ho Park
Keywords(s):
Basic Research Biomarker
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Cell Lines
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Cell Model
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Discovery/Research Tools
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Epithelial Cells
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Human Cell Lines
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In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools > Human Cell Lines
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Technology Classifications > Research Tools
Multi-Compartment Fallopian Tube Organoid Model
Unmet Need: Existing organoid models of the fallopian tube are architecturally simplified compared to the intricate epithelial-lumen interface in scale and structure, and there remains a need in the art for multi-compartment fallopian tube organoids that architecturally simulate the intricate architecture of the epithelial-lumen interface in structural...
Published: 3/14/2025
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Inventor(s):
Meng Horng Lee
,
Gabriella Russo
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Denis Wirtz
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Ashleigh Crawford
,
Wenxuan Du
Keywords(s):
Category(s):
Technology Classifications
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Technology Classifications > Medical Devices
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Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools > Human Cell Lines
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Technology Classifications > Research Tools > Research Stem Cells
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Technology Classifications > Research Tools > Microfluidics
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Clinical and Disease Specializations > Oncology
3D Shell MEAs for Electrically Active Organoids
Value Proposition· 3D shell MEAs is a novel platform for encapsulation, electrical stimulation, and recording of organoids· Electrophysiological measurements of electrically active 3D organoids. · Relevant to brain development, neurological disorders, drug screening; neuromorphic computing and brain-machine interfaces; and organoid...
Published: 3/14/2025
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Inventor(s):
David Gracias
,
Lena Smirnova
,
Qi Huang
Keywords(s):
Category(s):
Clinical and Disease Specializations > Autoimmunity
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Clinical and Disease Specializations > Neurology
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Clinical and Disease Specializations > Neurology > Motor Neuron Diseases
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Clinical and Disease Specializations > Neurology > Multiple Sclerosis
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Clinical and Disease Specializations > Neurology > Neurodegeneration
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Clinical and Disease Specializations > Neurology > Neuropathy
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Technology Classifications
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Technology Classifications > Research Tools > Stem Cells
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Technology Classifications > Research Tools > Assays
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Technology Classifications > Research Tools > Human Cell Lines
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Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools > Research Stem Cells
Monoclonal Antibodies Specific to AGK, for Research Purposes
Unmet Need: Acylglycerol kinase, AGK, is a protein in the TIMM22 translocon and is postulated to be important in cardiolipin biogenesis. Mutations in the gene encoding for AGK also can result in human disease, making the study of the protein important in understanding disease pathogenesis. Currently there are no validated human AGK specific antibodies,...
Published: 3/14/2025
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Inventor(s):
Steven Claypool
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Antibodies
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Technology Classifications > Research Tools > Research Antibodies
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Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools > Human Cell Lines
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Clinical and Disease Specializations > Metabolic Diseases
Monoclonal Antibody Specific to Human ANT1, for Research Purposes
Unmet Need: ANT1, also known as solute carrier family 25 member 4 (SLC25A4), is a protein important for mitochondrial energy production and is relevant in the research of human mitochondrial diseases. Mutations in the gene encoding for ANT1 also can result in human disease, making the study of the protein important in understanding disease pathogenesis....
Published: 3/14/2025
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Inventor(s):
Steven Claypool
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools > Human Cell Lines
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Technology Classifications > Research Tools > Research Antibodies
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Technology Classifications > Research Tools > Antibodies
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Clinical and Disease Specializations > Metabolic Diseases
Isogenic SF3B1 cell lines for drug discovery
SF3B1 mutations are present in a number of cancers. These mutations cause abnormal splicing within human cells and can lead to genomic alterations that confer cancerous phenotypes. Our research has led to the creation of isogenic cell lines that have specific mutations within the SF3B1 gene, thus mimicking human cancer mutations. In addition, we have...
Published: 3/13/2025
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Inventor(s):
Ben Ho Park
,
William Dalton
Keywords(s):
Cell Lines
,
Discovery/Research Tools
,
Human Cell Lines
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In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools > Human Cell Lines
Partitioning of Human Mesenchymal Stem Cells based on CD107a Expression
JHU Ref #: C15392Value PropositionImproved Stem Cell Isolation: Enables efficient and scalable separation of stem cells predisposed to fat or bone tissue regeneration.Clinically Feasible: Uses magnetic-activated cell sorting (MACS), a cost-effective and translational alternative to fluorescence-activated cell sorting (FACS).Enhanced Therapy Potential: Optimized...
Published: 3/14/2025
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Inventor(s):
Aaron James
Keywords(s):
Cell Lines
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Discovery/Research Tools
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Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Human Cell Lines
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Technology Classifications > Research Tools > Research Stem Cells
R-3327-AT6.3
Unmet NeedThere is increasing evidence supporting that ‘loss of function’ of metastasis suppressor genes plays an important role in cancer metastases. To help identify metastasis suppressor genes on human chromosomes, Johns Hopkins researchers have transferred individual human chromosomes into metastatic rat prostate cancer cells. Technology OverviewTo...
Published: 3/13/2025
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Inventor(s):
John Isaacs
Keywords(s):
Basic Research Biomarker
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Cancers
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Cell Lines
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Discovery/Research Tools
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Disease Indication
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Human Cell Lines
,
In Vitro Research Tool
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Prostate Cancer
Category(s):
Clinical and Disease Specializations
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Clinical and Disease Specializations > Men's Health
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Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools > Human Cell Lines
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Clinical and Disease Specializations > Oncology
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Technology Classifications > Research Tools
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Clinical and Disease Specializations > Oncology > Prostate Cancer
ESR1 Mutations in Human Breast Cancer Cells
TITLE ESR1 mutations in human breast cancer cells CASE NUMBER C13950 ABSTRACT Newly discovered mutations in the estrogen receptor alpha gene, ESR1, are thought to predict for resistance to certain endocrine therapies in breast cancers that express hormone receptors. FEATURES Johns...
Published: 3/13/2025
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Inventor(s):
David Chu
,
Ben Ho Park
Keywords(s):
Cell Lines
,
Discovery/Research Tools
,
Human Cell Lines
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In Vitro Research Tool
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Target-based Screening Tool
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Translational Research Biomarker
Category(s):
Technology Classifications > Research Tools
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Technology Classifications > Research Tools > Human Cell Lines
KA.1;KA.3 (human keratinocyte-iPSC)
Technical Details: Described are induced pluripotent stem cells (iPSC) generated from keratinocytes. Keratinocytes were plucked and cultured from human hair and reprogrammed using non-viral, non-integrating methods. The resulting iPSCs contain no evidence of integrated pluripotency transgenes. Associated Publication: PLoS One. 2012;7(8):e42838.
Published: 3/13/2025
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Inventor(s):
Elias Zambidis
Keywords(s):
Basic Research Biomarker
,
Cell Model
,
Discovery/Research Tools
,
In Vitro Research Tool
,
Stem Cells
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Stem Cells
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Human Cell Lines
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