Search Results - tong-chuan+he

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Conditional Tau Mouse Lines that Faithfully Recapitulate Alzheimer’s Disease-like Pathologies

Value Proposition: Effective therapy for Alzheimer’s disease (AD), the most common form of dementia and a devastating illness for the elderly, remains a great unmet need. For translational research and preclinical drug development, animal models that faithfully mimic the cardinal pathological features of AD are critical. A major limitation of current...

Published: 3/13/2025 | Inventor(s): Philip Wong, Donald Price, Tong Li

Keywords(s): Alzheimer's Disease, Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Broad Spectrum Chemoprotective Activities of Exemstane Against Cancer and Other Chronic Diseases: Synergism with Sulforaphane

Estrogens control the growth and development of the majority of breast cancers, the most prevalent malignancies of women in the developed world. Exemestane, a synthetic steroid commonly used clinically to prevent, delay progression of, and treat breast cancer, was designed to inhibit estrogen biosynthesis by aromatase. We have made the unexpected observation...

Published: 3/13/2025 | Inventor(s): Hua Liu, Paul Talalay

Keywords(s): Antagonists/Inhibitors, Cancers, Chemotherapy/Chemotherapy, Combination, Disease Indication, Natural compounds, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Nicastrin Knockout Mice: A Model for Human Head and Neck Squamous Cell Carcinoma

C10173: Mouse Model of Human Head and Neck Squamous Cell Carcinoma Technical Details: Cancers of the head and neck, the majority of which arise in the squamous cells that line the mucosal surfaces in the head and neck, account for 3% of all malignancies in the United States. Human head and neck squamous cell carcinoma is a clinically aggressive tumor,...

Published: 3/13/2025 | Inventor(s): Donald Price, Tong Li, Philip Wong

Keywords(s): Basic Research Biomarker, Cancers, Discovery/Research Tools, Disease Indication, Head & Neck Cancer, Head and Neck Cancer, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ear, Nose & Throat, Clinical and Disease Specializations > Oncology > Head & Neck Cancer, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Targeting of Stat-3 Signaling in the Hematopoietic System Evokes Multicomponent Therapeutic Antitumor Immunity

C04665: Targeting of Stat-3 Signaling in the Hematopoietic System Evokes Multicomponent Therapeutic Antitumor Immunity Technical Details: The immune system can act as an extrinsic suppressor of tumors. Therefore, tumor progression depends in part on mechanisms that down modulate intrinsic immune surveillance. Identifying these inhibitory pathways...

Published: 3/13/2025 | Inventor(s): Richard Jove, Hua Yu, Marcin Kortylewski, Drew Pardoll

Keywords(s): Biologics, Cancers, Combination, Disease Indication, Gene Therapy/ Immunotherapy, Protein, Single, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Stat3 Antagonists and Their Uses as Vaccines Against Cancer

C04271: Stat3 Antagonists and Their Uses as Vaccines Against Cancer Technical Details: The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression...

Published: 3/13/2025 | Inventor(s): Richard Jove, Hua Yu, Drew Pardoll

Keywords(s): Biologics, Cancers, Disease Indication, Immunotherapy, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Vaccines

A Simplified System for Generating Recombinant Adenoviruses

C03356: A Simplified System for Generating Recombinant Adenoviruses Technical Details: Recombinant adenoviruses provide a versatile system for gene expression studies and therapeutic applications. A strategy, which simplifies the generation and production of such viruses is reported here. A recombinant adenoviral plasmid is generated with a minimum...

Published: 3/13/2025 | Inventor(s): Tong-Chuan He, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Adeno Virus, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Infectious Diseases, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools > Viruses, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools