Search Results - clinical+and+disease+specializations+%3e+dermatology

17 Results

Sort By:

Activating Mutations in GNAQ Sensitive to Antibiotic; Novel Molecular Pathway and Treatment Target for Capillary Malformations and Related Syndromes

Value Proposition: · Antibiotic treatment strategy for capillary malformations and Sturge-Weber Syndrome. · Selectively targets endothelial cells with the pathogenic GNAQ mutations using puromycin · Inhibits cell proliferation and reduces cell survival via activation of TRP6/NFAT signaling pathway · Compatible with various drug...

Published: 9/26/2024 | Inventor(s): Anne Comi, Jonathan Pevsner, Zhenhua Huang, Douglas Marchuk

Keywords(s): Biomarker, Disease Indication, Genetic Disorders, Mechanism-of-action Biomarker, Skin Disorders, Sturge-Weber Syndrome, Sturge-Weber Syndrome (SWS), Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Dermatology, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Dermatology > Sturge-Weber Syndrome

Orally Administered Metformin to Treat Hair Loss in Central Centrifugal Cicatricial Alopecia

Value Proposition:Potential first-in-class treatment for CCCA, a condition impacting a substantial proportion of Black women. Repurposes metformin, a well-studied and naturally available compound with an established safety profile and a low cost of manufacturing.Oral administration as a simple, self-managed treatment. Unmet Need:Central centrifugal...

Published: 9/27/2024 | Inventor(s): Crystal Aguh

Keywords(s):

Category(s): Clinical and Disease Specializations > Dermatology > Alopecia, Clinical and Disease Specializations > Dermatology, Technology Classifications > Therapeutic Modalities > Repurposed Drugs

Oil based formulation to treat hair loss.

Value Proposition· Non-irritating formulation of minoxidil to treat hair loss· Increased efficacy and tolerance of minoxidil· Suitable for individuals with curly hair· Ointment or oil-based formulation eliminates the need to dissolve minoxidil in irritating vehicleUnmet NeedMinoxidil, which is the only approved medication...

Published: 9/27/2024 | Inventor(s): Crystal Aguh

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology

Compositions and Methods for Treating Melanoma--Further Modifications

Unmet NeedTherapeutic cancer vaccines aim to activate the antitumor T cell response. These vaccines are designed to prime naïve antitumor T cells, by activating antigen presenting cells, particularly dendritic cells (DCs). DNA-based cancer vaccines are a particularly promising approach, partially due to the ease with which they can be manufactured....

Published: 9/26/2024 | Inventor(s): Richard Markham, James Gordy

Keywords(s): Biologics, Cancers, Combination, Disease Indication, Melanoma, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Vaccine

Category(s): Clinical and Disease Specializations > Oncology > Melanoma, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines

A system and methods for the detection of the LD rash and other skin conditions

Unmet NeedThe direct medical costs associated with Lyme disease in the United States are estimated at 2.5 billion dollars annually. Precise diagnosis from laboratory results are only most accurate if taken within a few weeks of being infected. The problem is the symptoms are wide varying and come and go. In addition, one test ELISA (enzyme-linked immunosorbent...

Published: 9/26/2024 | Inventor(s): John Aucott, Philippe Burlina, Neil Joshi, Seth Billings, Elise Ng

Keywords(s): Disease Indication, Image Processing Software, Imaging and Sensing Systems, In Vivo Medical Imaging, Infectious Diseases, Lyme Disease, Pattern Recognition Software, Skin Disorders

Category(s): Clinical and Disease Specializations > Infectious Diseases > Lyme Disease, Clinical and Disease Specializations > Dermatology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Diagnostics > Diagnostic Imaging

Screening Method to Identify Scleroderma Immune Responses with Anti-cancer Activity, and Induction of such Immune Responses for Cancer Therapy

Unmet NeedEpidemiological studies have shown that patients with scleroderma, a type of autoimmune rheumatic disease affecting the skin and connective tissues, have an increased risk of developing cancer relative to the general population. The exact etiology of scleroderma is still unknown. The Scleroderma Foundation estimates about 100,000 to 300,000...

Published: 9/26/2024 | Inventor(s): Ami Shah, Livia Casciola-Rosen, Antony Rosen, Takeru Igusa, Marikki Laiho

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Risk Stratification, Scleroderma, Skin Disorders, Skin Fibrosis, Therapeutic Matter, Therapeutic Substance, Therapeutics

Novel biocompatible wireless monitoring device for the prevention of pressure ulcers

INVENTION NOVELTY The Mercury Patch is the first low-cost, wireless wound care product that provides both a monitoring and therapeutic function to help prevent pressure ulcer development within a hospital setting. VALUE PROPOSITION Existing pressure monitoring devices focus on expensive mattress overlay systems, which are cost-prohibitive and impractical...

Published: 9/26/2024 | Inventor(s): Matthew Nojoomi, Kelly Lacob, Madeline Wilson, Alison Wong, Samuel Zschack, Justin Sacks

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Disease Indication, Implanted Device, Implants, Interventional and Surgical Systems, Measurement Tool, Pressure Ulcer, Skin Disorders, Surgical Intervention Method, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology > Pressure Ulcer, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Dermatology, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices

Fibrillin 1 Mutant Mice (W1572C Mutant Strain) and (D1545E Mutant Strain)

TITLE: Fibrillin 1 Mutant Mice (W1572C Mutant strain) and (D1545E Mutant Strain)CASE NUMBER: C13499ABSTRACTFibrillin1 D1545E Mutant StrainThese mice carry a D1545E mutation in the mouse Fbn1 gene and serve as a model of human stiff skin syndrome with increased collagen deposition in the dermis, decreased subcutaneous fat, and circulating anti-nuclear...

Published: 9/26/2024 | Inventor(s): Harry Dietz, Elizabeth Gerber

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Cell Lines, Mouse Model, Skin Disorders, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Dermatology

Hyperspectral Imaging for Skin Cancer Detection

Invention novelty: This technology is a novel device. It can measure quantitative data, record spectral signature, and screen skin tissue for abnormalities. This hyperspectral video surveillance system can determine and assess the skin’s constitutive elements spatially and temporally, ultimately detecting abnormalities and the potential presence...

Published: 9/26/2024 | Inventor(s): Saurabh Vyas, Philippe Burlina, Amit Banerjee, Luis Garza

Keywords(s): Cancers, Clinical Diagnostics, Diagnostic Tool, Disease Indication, Measurement Tool, Skin Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

dsRNA Analogues to Promote Skin Regeneration

Invention novelty: This invention is a method to increase skin regeneration and wound healing. It relies on activation of the innate immune response involving Toll-like receptor 3 (TLR3). Value Proposition: Current approaches to wound healing and skin regeneration are limited in that they do not lead to scar free wounds. This technology relies on activation...

Published: 9/26/2024 | Inventor(s): Amanda Nelson, Luis Garza

Keywords(s): Biologics, Disease Indication, Follicular Neogenesis, Follicular neogenesis, Hair Disorders, Nucleic Acid, Therapeutic Matter, Therapeutic Substance, Therapeutics, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology > Follicular Neogenesis, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Clinical and Disease Specializations > Dermatology, Technology Classifications > Therapeutic Modalities

1 2