Search Results - clinical+and+disease+specializations+%3e+dermatology

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Value Proposition· Flexibility to be combined with various types of topical medications or delivery mechanisms· Easily manufactured key ingredients Unmet Need· Chronic wounds persist for long periods of time without adequate healing response. They may take various forms, such as vascular ulcers, diabetic foot ulcers, or sacral pressure...

Published: 3/13/2026 | Inventor(s): Luis Garza, Gaofeng Wang

Keywords(s):

Category(s): Clinical and Disease Specializations > Dermatology > Pressure Ulcer, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Wound Healing

MRGPRX4 Targeted Therapeutics and Research Tools for Melanoma Diagnosis, Modeling, and Treatment

Unmet NeedMelanoma incidence continues to rise sharply, and current therapies remain inadequate for many patient populations, especially those lacking drug‑targetable mutations such as BRAF. A major limitation in melanoma research and drug discovery is the absence of models and targets that reflect the biology of non‑BRAF‑driven melanoma. Recent findings...

Published: 3/13/2026 | Inventor(s): Xinzhong Dong, Naina Gour

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Melanoma, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Dermatology

Orthotopic Models of Acral Melanoma to Screen Therapy Strategies

Value Proposition· The first orthotopic model of acral melanoma (AM) that replicates the anatomical, transcriptional, and metastatic hallmarks of human disease.· Replicates the plasticity of AM-specific cell states, which has not been demonstrated in any other orthotopic model of AM.· Demonstrates that the microenvironment of plantar...

Published: 3/13/2026 | Inventor(s): Vito Rebecca

Keywords(s):

Category(s): Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Melanoma, Clinical and Disease Specializations > Research Tools

Activating Mutations in GNAQ Sensitive to Antibiotic; Novel Molecular Pathway and Treatment Target for Capillary Malformations and Related Syndromes

Value Proposition: · Antibiotic treatment strategy for capillary malformations and Sturge-Weber Syndrome. · Selectively targets endothelial cells with the pathogenic GNAQ mutations using puromycin · Inhibits cell proliferation and reduces cell survival via activation of TRP6/NFAT signaling pathway · Compatible with various drug...

Published: 3/12/2026 | Inventor(s): Anne Comi, Jonathan Pevsner, Zhenhua Huang, Douglas Marchuk

Keywords(s): Biomarker, Disease Indication, Genetic Disorders, Mechanism-of-action Biomarker, Skin Disorders, Sturge-Weber Syndrome, Sturge-Weber Syndrome (SWS), Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Dermatology, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Dermatology > Sturge-Weber Syndrome

Orally Administered Metformin to Treat Hair Loss in Central Centrifugal Cicatricial Alopecia

Value Proposition:Potential first-in-class treatment for CCCA, a condition impacting a substantial proportion of Black women. Repurposes metformin, a well-studied and naturally available compound with an established safety profile and a low cost of manufacturing.Oral administration as a simple, self-managed treatment. Unmet Need:Central centrifugal...

Published: 3/13/2026 | Inventor(s): Crystal Aguh

Keywords(s):

Category(s): Clinical and Disease Specializations > Dermatology > Alopecia, Clinical and Disease Specializations > Dermatology, Technology Classifications > Therapeutic Modalities > Repurposed Drugs

Oil based formulation to treat hair loss.

Value Proposition· Non-irritating formulation of minoxidil to treat hair loss· Increased efficacy and tolerance of minoxidil· Suitable for individuals with curly hair· Ointment or oil-based formulation eliminates the need to dissolve minoxidil in irritating vehicleUnmet NeedMinoxidil, which is the only approved medication...

Published: 3/13/2026 | Inventor(s): Crystal Aguh

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology

Scalable, Event-based Sensing Using Wireless Sensor Elements Embedded in Flexible Elastomer

JHU Ref #: C16118Technology Description· Researchers at Johns Hopkins have developed an e-skin tactile sensor with improved sensitivity to pressure events both in time and space. · Event-based sensing approach allows for enhanced spatial and temporal resolution of stimuli and efficient data collection. · Events are transmitted to...

Published: 3/13/2026 | Inventor(s): Ariel Slepyan

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Clinical and Disease Specializations > Dermatology

Compositions and Methods for Treating Melanoma--Further Modifications

Unmet NeedTherapeutic cancer vaccines aim to activate the antitumor T cell response. These vaccines are designed to prime naïve antitumor T cells, by activating antigen presenting cells, particularly dendritic cells (DCs). DNA-based cancer vaccines are a particularly promising approach, partially due to the ease with which they can be manufactured....

Published: 3/13/2026 | Inventor(s): Richard Markham, James Gordy

Keywords(s): Biologics, Cancers, Combination, Disease Indication, Melanoma, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Vaccine

Category(s): Clinical and Disease Specializations > Oncology > Melanoma, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines

A system and methods for the detection of the LD rash and other skin conditions

Unmet NeedThe direct medical costs associated with Lyme disease in the United States are estimated at 2.5 billion dollars annually. Precise diagnosis from laboratory results are only most accurate if taken within a few weeks of being infected. The problem is the symptoms are wide varying and come and go. In addition, one test ELISA (enzyme-linked immunosorbent...

Published: 3/13/2026 | Inventor(s): John Aucott, Philippe Burlina, Neil Joshi, Seth Billings, Elise Ng

Keywords(s): Disease Indication, Image Processing Software, Imaging and Sensing Systems, In Vivo Medical Imaging, Infectious Diseases, Lyme Disease, Pattern Recognition Software, Skin Disorders

Category(s): Clinical and Disease Specializations > Infectious Diseases > Lyme Disease, Clinical and Disease Specializations > Dermatology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Diagnostics > Diagnostic Imaging

Screening Method to Identify Scleroderma Immune Responses with Anti-cancer Activity, and Induction of such Immune Responses for Cancer Therapy

Unmet NeedEpidemiological studies have shown that patients with scleroderma, a type of autoimmune rheumatic disease affecting the skin and connective tissues, have an increased risk of developing cancer relative to the general population. The exact etiology of scleroderma is still unknown. The Scleroderma Foundation estimates about 100,000 to 300,000...

Published: 3/13/2026 | Inventor(s): Ami Shah, Livia Casciola-Rosen, Antony Rosen, Takeru Igusa, Marikki Laiho

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Risk Stratification, Scleroderma, Skin Disorders, Skin Fibrosis, Therapeutic Matter, Therapeutic Substance, Therapeutics

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