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Novel monoclonal antibody inhibitors targeting potassium channel KCNK9

Unmet Need:KCNK9 is one of 15 mammalian subtypes in the highly conserved family of two-pore domain potassium channels (K2P). Under physiological conditions, KCNK9 is primarily expressed in the brain where it serves to maintain cellular membrane potentials. However, overexpression of KCNK9 has been detected in breast, lung, skin, and other cancers, and...

Published: 6/26/2025 | Inventor(s): John Laterra, Han Sun, Min Li, Amy Fulton

Keywords(s): Antibodies, Biologics, Breast Cancer, Cancers, Disease Indication, Lung Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Lung Cancer

Combined mammography and quantitative ultrasound breast imaging system

Value Proposition· Comprehensive Examination – integrates conventional ultrasound, ultrasound tomography, photoacoustic imaging, and mammography.· Superior Accuracy – multiple imaging modalities deliver comprehensive and precise breast tissue analysis, reducing the risk of overdiagnosis and/or overtreatment. · Improved Early Detection...

Published: 6/27/2025 | Inventor(s): Emad Boctor, Yixuan Wu, Jeeun Kang, Keshuai Xu, Hyunwoo Song, Russell Taylor, Yuxin Chen, Yifan Yin, Joseph Stayman, Mohammad Salehizadeh

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health

Bias in Maternal Health Care: A Measure of Attitudes and Practice

Unmet Need: The quality of health care depends on the competence and motivation of the health workers. However, limits arise due to the inability to properly assess the proximal training outcomes for health care providers and evaluate the effectiveness of implicit bias training. The attitude and biases that maternal care workers hold can significantly...

Published: 6/27/2025 | Inventor(s): Andreea Creanga, Kelly Bower, Nicole Warren, Briana Kramer, Saifuddin Ahmed, Jennifer Callaghan-Koru

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Education Tech, Clinical and Disease Specializations > Women's Health, Clinical and Disease Specializations > Reproductive Health

Methylation Markers that Provide Molecular Diagnosis by Distinguishing Between Benign from Malignant Breast Cancer and Predict Risk

Unmet NeedBreast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in low and middle income countries (LMICs), and is expected to increase in incidence due to longer life expectancies, decreased burden of infectious diseases, and changes in reproductive risk factors. In LMICs, breast cancer mortality rates are as high...

Published: 6/26/2025 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Bradley Downs

Keywords(s): Assay, Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Therapeutic Matter, Therapeutics

Breast Biopsy Needle Guide

Unmet NeedAround 250,000 patients are diagnosed with breast cancer each year, and overall, 1 in 8 women will be diagnosed with breast cancer in her lifetime. In order for proper diagnosis, biopsies must be performed, usually requiring minor, open surgery. The procedures commence with needle localization, where the radiologist inserts a needle into the...

Published: 6/27/2025 | Inventor(s): Andrew Schulick, Devika Singh

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Diagnostics > In Vivo Diagnostics, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health

Method for Cervicovaginal Secretion Transplants to Restore Healthy Vaginal Microbiota

Approximately one-third of all women currently have bacterial vaginosis (BV), a condition where the vaginal microbiota is not dominated by lactobacilli. Another one-third of women have mixed vaginal microbiota (intermediate BV), and only one-third of women have healthy, lactobacilli-dominated microbiota. Women with BV are known to have >2-6-fold...

Published: 6/26/2025 | Inventor(s): Justin Hanes, Richard Cone, Laura Ensign

Keywords(s): Biologics, Disease Indication, Therapeutic Matter, Therapeutic Substance, Therapeutics, Transplant, Transplants, Women's Health

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Microbiome, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities

DNA Methylation Biomarkers of Post Partum Depression Risk

Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting postpartum depression (PPD) risk . Value Proposition: PPD occurs in approximately 10-15% of women and represents a serious health risk to both mothers and their offspring. Increased depression risk in pregnant women is not predicted by hormonal fluctuations. This...

Published: 6/26/2025 | Inventor(s): Zachary Kaminsky, Jennifer Payne, Todd Gould

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Post Partum Depression, Postpartum Depression, Prognostic Biomarker, Psychiatric Diseases

HER2-positive breast cancer cell lines derived from transgenic HuHER2 mouse model

Unmet NeedPreclinical evaluation of therapeutic agents against metastatic breast cancer require cell lines and animal models that recapitulate clinical metastatic breast cancer.Technology OverviewResearchers at Johns Hopkins University extracted primary mammary gland tumors, purified the epithelial breast cancer cells over a number of passages, and...

Published: 6/26/2025 | Inventor(s): George Sgouros, Sunju Park

Keywords(s): Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Exomic sequences of ovarian clear cell carcinomas

Ovarian Clear Cell Carcinoma (OCCC) is an aggressive cancer that is generally resistant to therapy. To gain novel insights into the genetic origin of this tumor type, we determined the exomic sequences of eight tumors after immunoaffinity purification of neoplastic cells. Through comparison to normal cells from the same patients, we identified four...

Published: 6/26/2025 | Inventor(s): Sian Jones, Victor Velculescu, Kenneth Kinzler, Nickolas Papadopoulos, Ie-Ming Shih, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Ovarian Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Oncology

Unique Organ-specific Metastatic Human Breast Cancer Cell Lines

TITLEUnique organ-specific metastatic human breast cancer cell lines CASE NUMBERC13010 ABSTRACTA history of clinical observations has demonstrated that breast cancer metastases are capable of sustained deadly growth in several vital organs, such as, lung, brain, and liver as well as bone/marrow, ovaries, adrenals, lymph nodes, and skin. In order to...

Published: 6/26/2025 | Inventor(s): Venu Raman, Paul Winnard

Keywords(s): Breast Cancer, Cancer Cells, Cancers, Cell Lines, Cell Model, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

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