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Cancer in Angiogenesis

Unmet NeedIn the United States alone, almost 8.5 million people suffer from peripheral artery disease (PAD). The market for PAD and Peripheral Vascular Disease (PVD) is expected to reach $378.53 million with a CAGR of 7.06% by 2024. Therapeutic angiogenesis are therapies aimed at growing new vessels into compromised tissue. Wound healing, PAD, and coronary...

Published: 3/13/2025 | Inventor(s): Andrew Schulick

Keywords(s): Biologics, Cardiovascular Diseases, Cell Model, Coronary Heart Disease, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Peripheral Artery Disease, Stem Cells, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Whole cell, Wound Healing

Category(s): Technology Classifications > Therapeutic Modalities > Stem Cells, Clinical and Disease Specializations > Wound Healing, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Stem Cells

Three-dimensional Vascular Network Assembly from Diabetic Patient-derived Induced Pluripotent Stem Cells

In diabetics, hyperglycemia results in deficient endothelial progenitors and cells, leading to cardiovascular complications. We aim to engineer three-dimensional (3D) vascular networks in synthetic hydrogels from type-1 diabetes (T1D) patient-derived human induced pluripotent stem cells (hiPSCs), thus serving as a transformative autologous vascular...

Published: 3/13/2025 | Inventor(s): Sharon Gerecht, Xin Yi Chan, Quinton Smith, Yu-I Shen

Keywords(s): Biologics, Cell Model, Diabetes, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Metabolic Disorders, Stem Cells, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Translational Research Biomarker, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Stem Cells

Smooth-muscle-like-cells (SMLCs) Derived from Human Embryonic Stem Cells (hESCs) Support Cord-like Structure in vitro

This invention relates, e.g., to a method for differentiating mammalian (e.g., human) pluripotent stem cells (PSCs) into smooth muscle-like cells (SMLCs) in vitro, comprising a) plating a single-cell suspension of PSCs that are smaller than 50 μm at a seeding concentration of about 5×104 cells/cm2-about 1×105 cells/cm2 onto a suitable surface, and culturing...

Published: 3/13/2025 | Inventor(s): Sharon Gerecht, Maureen Wanjare, Elaine Vo, Donny Hanjaya-Putra

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Human Cell Lines, Implanted Device, Implants, In Vitro Research Tool, Stem Cells, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Stem Cells, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Human Cell Lines

Methods to Accelerate Healing of Injured Tissues via Stem Cells in Nanofiber Patches

C12353: Stem Cell Developed Patches for Accelerated AngiogenesisNovelty: This technology describes compositions and methods of use of certain patches, with infused stem cells and/or derived growth factors, used for accelerated healing of tissue injuries.Value Proposition: Existing therapeutic angiogenesis techniques that employ individual growth factors...

Published: 3/13/2025 | Inventor(s): Xiomara Calderon-Colon, Zhiyong Xia, Chao-Wei Hwang, Peter Johnston, Virginia Bogdan

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Stem Cells, Technology Classifications > Medical Devices