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Johns Hopkins Atlas of Ovarian Tumor Pathology iPad App

Unmet NeedOvarian cancer is the most common cancer in women and is the fifth leading cause of cancer death in women. Every year, a quarter of a million women around the world are diagnosed with ovarian cancer. The treatment for ovarian cancer is most effective when the cancer is caught early. In order to improve early diagnosis of ovarian cancer, residents,...

Published: 6/20/2024 | Inventor(s): Ralph Hruban, Emanuela Veras, Ayse Ayhan, Tsui-Lien Mao, Marissa White, Norman Barker, Toby Cornish

Keywords(s): Cancers, Disease Indication, Ovarian Cancer, Trademark

Category(s): Clinical and Disease Specializations > Oncology > Ovarian Cancer, Technology Classifications > Computers, Electronics & Software > Education Tech, Trademark

Biomarkers of Therapeutic Response in Ovarian Cancer

Unmet NeedOvarian cancer is the most common cause of death among gynecological cancers and is associated with poor outcomes and low overall survival rates. The current standard of care involves surgical resection of the solid tumor, followed by chemotherapy. This type of therapy has limited success among women with advanced disease, and often results...

Published: 6/20/2024 | Inventor(s): Victor Velculescu, Robert Scharpf, Eniko Papp, Dorothy Hallberg, Dennis Slamon, Gottfried Konecny

Keywords(s): Cancers, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Ovarian Cancer, Target-based Screening Tool

Category(s): Clinical and Disease Specializations > Oncology > Ovarian Cancer

Exomic sequences of ovarian clear cell carcinomas

Ovarian Clear Cell Carcinoma (OCCC) is an aggressive cancer that is generally resistant to therapy. To gain novel insights into the genetic origin of this tumor type, we determined the exomic sequences of eight tumors after immunoaffinity purification of neoplastic cells. Through comparison to normal cells from the same patients, we identified four...

Published: 6/20/2024 | Inventor(s): Sian Jones, Victor Velculescu, Kenneth Kinzler, Nickolas Papadopoulos, Ie-Ming Shih, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Ovarian Cancer

Creation of Murine Ovarian Cancer Cell Line Suitable for Non-Invasive Imaging

Trackable Murine Ovarian Cancer Cell LineJHU REF: [C12340]Invention novelty: This tangible material is a transgenic murine ovarian cancer cell line expressing luciferase for non-invasive monitoring of tumor load in a mouse bearing this cell line. Value Proposition: There is a need for cancer cell lines that can be monitored/detected non-invasively....

Published: 6/20/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung

Keywords(s): Animal Imaging Tools, Assay, Basic Research Biomarker, Cancers, Cell Lines, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Ovarian Cancer

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Technology Classifications > Diagnostics > Diagnostic Imaging

Human Mesothelin Expressing ID8-Defb29 Vegf/Luc (ID8-Defb29 Vegf-Luc/Hmeso)

ABSTRACTCancer immunotherapy targeting mesothelin represents a potentially plausible approach for the control of ovarian cancer as most ovarian cancers express high levels of mesothelin. In the current study, JHU researchers created a mesothelin-positive luciferase-expressing ovarian cancer model, ID8-Defb29 Vegf /luc. ID8-Defb29 Vegf –luc was infected...

Published: 6/20/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung

Keywords(s): Animal Imaging Tools, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, In Vivo Research Tool, Ovarian Cancer

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology > Ovarian Cancer

Small Molecule Inhibitors Targeting PBX1-DNA Binding to Treat Drug Resistant Cancers

Invention novelty: Panel of newly-synthesized small molecule antagonists of PBX1-DNA interaction for the treatment of different cancers and other non-neoplastic diseases. Value Proposition: Pre-B-cell leukemia homeobox-1 (PBX1) is a homeodomain transcription factor that interacts with DNA and other proteins to regulate a variety of biological processes...

Published: 6/20/2024 | Inventor(s): Tian-Li Wang, Ie-Ming Shih, Jin Jung, Mark Vaal, Alexander Stoeck

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Novel, Ovarian Cancer, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Ovarian Cancer

Selectively Targeted Coating of Tumor Cells with Foreign Antigenic Peptide Renders Tumor Cells Susceptible to Antigen-specific CD8+ T Cell-mediated Killing

C11613: Novel Immunotherapy for Ovarian CancerNovelty: This invention is an immunotherapy that coats tumor cells with foreign antigenic peptide thereby rendering the coated tumor cells susceptible to immune recognition and elimination.Value Proposition: Cancer is the second most common cause of death in the industrialized world. Ovarian cancer is the...

Published: 6/20/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung

Keywords(s): Antigens, Biologics, Cancers, Disease Indication, Immunotherapy, Ovarian Cancer, Peptide, Protein, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Proteins, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Technology Classifications > Therapeutic Modalities > Peptides

Ovarian Cancer Methylome and Its Potential as Biomarker

C10640: Methylation Based Biomarkers for Ovarian Cancer Value Proposition: ADVANTAGES: • Biomarkers for early detection/diagnosis of ovarian cancer • Predictive biomarkers for risk of developing ovarian cancer • Biomarkers for the prediction of therapy response • Biomarkers to determine preventative interventions •...

Published: 6/20/2024 | Inventor(s): Leonel Maldonado Gonzalez, Mariana Brait Rodrigues De Oliveira, Mohammad Hoque

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Ovarian Cancer, Prognostic Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers

BRCA2 KO Lines for Drug Discovery

C05188: BRCA2 KO Lines for Drug Discovery Technical Details: BRACA2 is a DNA repair gene. Mutations in BRACA2 cause an inherited risk of breast, ovarian and pancreatic cancers. The cancer cell lines are engineered to lack BRACA2 and are useful screening tools for chemotherapeutic or chemopreventative agentsLooking for Partners: The BRACA2 KO cell...

Published: 6/20/2024 | Inventor(s): Thomas Hucl, Scott Kern

Keywords(s): Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Ovarian Cancer, Pancreatic Cancer, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines

Human BARX2 Genes

C03545: Human BARX2 Gene Technical Details: Surprisingly, it has been found that the Barx2 gene is mutated in ovarian cancer. The invention provides methods of diagnosis, prognosis and treatment of cancer related to the Barx2 gene. Looking for Partners: This technology could be commercialized as diagnostic and prognostic kits and therapeutics...

Published: 6/20/2024 | Inventor(s): Barry Nelkin, Alan Krasner

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Natural compounds, Non-novel, Ovarian Cancer, Predicted Novelty, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities