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A method for inhibiting UHRF1 in colorectal cancer

Value PropositionReversal of colorectal cancer-specific DNA hypermethylationmRNA-based strategy for UHRF1 inhibitionA lipid nanoparticle-based delivery platformUnmet Need1 out of 24 people will develop colorectal cancer. Current technologies do not maximize the bodies’ native ability to suppress tumors. Existing therapies lack specificity and cause...

Published: 9/12/2025 | Inventor(s): Stephen Baylin, Srinivasan Yegnasubramanian, Ying Cui, Xiangqian Kong

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Intrinsically Disordered Proteins as Emulsifiers

Value PropositionNatural Emulsification – introduces a new type of flexible protein (MEG proteins) found in cells to naturally keep liquid mixtures stable.Biocompatible and Renewable – MEG proteins are organic, naturally occurring, and renewable, offering a sustainable alternative to synthetic or inorganic emulsifiers.Dual-Phase Stabilization – uniquely...

Published: 9/12/2025 | Inventor(s): Geraldine Seydoux, Andrea Putnam, Andrew Folkmann

Keywords(s):

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Enhanced Fluorescence Signal through the Application of Aromatic Additives onto the Microscopy Sample for Standard Fluorescence, Fluorescence Microscopy, and Combined Fluorescence MALDI Microscopy/imaging

Value Proposition· Enhanced Fluorescence Intensity: Increases signal strength, enabling detection of molecules that are undetectable with traditional fluorescence microscopy and imaging techniques· Improved Efficiency: Requires less dye to achieve strong fluorescence signals and protects the sample from oxidative degradation, reducing reagent...

Published: 9/12/2025 | Inventor(s): Kristine Glunde, Ethan Yang, Caitlin Tressler, Scot Kuo, Hoku Kahele West-Foyle, Xinyi Shen

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Medical Devices > Imaging

Chemically Inducible Hetero-trimerization Tool

Marketing Summary DraftChemically Inducible Hetero-trimerization ToolJHU Ref #: C16287Value Proposition· Chemically Inducible Trimerization (CIT) for introducing a third recruitable component· Addition of rapamycin through rational splitting of FKBP and FRB leads to efficient trimerization· Has robust cellular applications e.g.,...

Published: 9/12/2025 | Inventor(s): Takanari Inoue, Di Wu, Masaki Kikuchi, Onur Dagliyan, Hideki Nakamura, Nikolay Dokholyan, Takashi Umehara

Keywords(s):

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Intracellular actuator that generates and manipulates physical force in living cells

Marketing Summary DraftIntracellular actuator that generates and manipulates physical force in living cellsJHU Ref #: C14896Value PropositionPhysical force generation inside living cells via light irradiation and chemical treatmentThis research tool can be applied to arbitrary intracellular targets in a specific and spatiotemporal mannerSystem is built...

Published: 9/12/2025 | Inventor(s): Takanari Inoue, Hideki Nakamura, Elmer Rho

Keywords(s): Discovery/Research Tools, Peptides, Recombinant Proteins, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Vectors & Plasmids

Bio-engineered enzymes to replace thermal cycler machine in PCR

Unmet NeedThe COVID-19 pandemic underscored the importance of rapid and sensitive testing for infectious material to limit the spread of a virus. The gold standard of testing is detection of viral DNA by polymerase chain reaction (PCR). PCR has long been used in laboratory settings and can reliably detect viral infection at a highly sensitive level...

Published: 9/12/2025 | Inventor(s): Taekjip Ha, Momcilo Gavrilov

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Infectious Diseases

Aptamer Regulated Transcription for In-vitro Sensing and Transduction

Unmet Need: Biomarkers are an incredibly important tool for diagnosing everything from autoimmune diseases, cancer, and metabolic disorders to creating personalized medicine and recommendations for certain treatments such as transplants, chemotherapy, vaccination, etc. Currently, most protein biomarker detection is still done by conventional protein...

Published: 9/12/2025 | Inventor(s): Heon Joon Lee, Rebecca Schulman, Samuel Schaffter

Keywords(s):

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Biocatalytic use of nonheme iron proteins for molecular functionalization

Unmet Need:Enzymes are biocatalysts, which accelerate various biochemical reactions. In the current scenario, enzymes serve as useful biocatalysts for several industrial processes and chemical reactions. Moreover, they play an important role in chemical engineering, food technology, and agriculture. The utilization of enzymes minimizes the cost, reduces...

Published: 9/12/2025 | Inventor(s): Xiongyi Huang, Anthony Huls, Qun Zhao, Jinyan Rui, Zhenhong Chen, James Zhang

Keywords(s):

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Albumin-Flt3L Fusion Protein to Enhance Anti-Tumor Immunity and Antigen-specific T-cell Cytotoxicity

Unmet Need: Active immunotherapy, such as anti-PD-1/PD-L1 and anti-CTLA-4 checkpoint blockage, involves the administration of molecules to mobilize host immune cells to recognize and kill tumors. Proper presentation of tumor antigens through antigen presenting cells is a prerequisite to elicit a potent immune response. Current strategies enhance antigen...

Published: 9/12/2025 | Inventor(s): T.c. Wu, Chien-Fu Hung, Brandon Lam

Keywords(s): Biologics, Cancers, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Research Instrument, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Immunology, Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Targets

Diazen-1-ium-1, 2-diolate Derivatives as New Nitroxyl Donors

Unmet NeedHeart failure is a continuously growing health issue in the United States. According to a study by the CDC, approximately 6.2 million Americans had heart failure between the years 2013-2016, and that number is expected to breach 8 million by 2030 (see AHA). Acute decompensated heart failure (ADHF), a potentially fatal cause of respiratory...

Published: 9/11/2025 | Inventor(s): Christopher Pavlos, Preeya Kapur Boppana, John Toscano

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

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