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Clinical-Grade Therapeutic Progenitors Generated from Universal Donor Tankyrase/PARP-Inhibited Pluripotent Stem Cell Banks

Unmet Need / Invention Novelty: Regenerative cell therapies with conventional, lineage-primed human induced pluripotent stem cells (hiPSC) are limited by variable differentiation efficiency and poor in vivo functionality. There is an unmet need to establish novel methods for efficiently generating functional and transplantable therapeutic progenitors. Technical...

Published: 9/27/2024 | Inventor(s): Elias Zambidis, Ludovic Zimmerlin

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Research Stem Cells

3D Shell MEAs for Electrically Active Organoids

Value Proposition· 3D shell MEAs is a novel platform for encapsulation, electrical stimulation, and recording of organoids· Electrophysiological measurements of electrically active 3D organoids. · Relevant to brain development, neurological disorders, drug screening; neuromorphic computing and brain-machine interfaces; and organoid...

Published: 9/27/2024 | Inventor(s): David Gracias, Lena Smirnova, Qi Huang

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Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Motor Neuron Diseases, Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Research Stem Cells

SpinΩ – A Multi-well Bioreactor for Culturing 3D Organoids

UNMET NEEDSpinning bioreactors have been used for three-dimensional (3D) cell culture and generation of organ-like tissues (organoids). However, current spinning bioreactors available on the market (e.g. the Corning® disposable spinner flasks) have several major challenges including requiring a large volume of medium and incubator space, large sample-to-sample...

Published: 9/26/2024 | Inventor(s): Hongjun Song, Guo-li Ming, Mingxi Song, Christopher Hadiono, William Jeang, Ha Nam Nguyen, Xuyu Qian

Keywords(s): Bioreactor-based Manufacturing, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Industrial Manufacturing, Research Instrument, Stem Cells

Category(s): Technology Classifications > Research Tools, Technology Classifications > Industrial Tech > Bioreactors, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Bioreactors, Technology Classifications > Engineering Tech > Industrial Manufacturing

Functional Fibers for Ex Vivo Expansion of Stem and Progenitor Cells

NeedUmbilical cord blood is a promising alternative source of hematopoietic stem/progenitor cells (HSPCs) for allogeneic and autologous hematopoietic stem cell transplantation for the treatment of a variety of hematological disorders and as supportive therapy for malignant diseases. However, the low number of HSPCs obtainable from a single donor restricts...

Published: 9/26/2024 | Inventor(s): Kam Leong, Kian-Ngiap Chua, Seeram Ramakrishna, Hai-Quan Mao

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Stem Cells

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools

Induced Pluripotent Stem Cell Lines (BC1 and C7) and Plasmids (pEB-C5, pEB-Tg)

The Material consists of two induced pluripotent stem (iPS) cell lines derived from human bone marrow and cord blood.and plasmids used to create these virus-free and integration-free human iPS cell lines.

Published: 9/26/2024 | Inventor(s): Linzhao Cheng

Keywords(s): Basic Research Biomarker, Cell Model, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Plasmid, Research Reagent, Stem Cells

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

Vascular Progenitors Generated from Tankyrase Inhibitor-Regulated Naïve Diabetic Human iPSC Potentiate Efficient Revascularization of Ischemic Retina

Unmet NeedIn the United States, approximately 14.6 million Americans are estimated to suffer from diabetic retinopathy by the year 2050 (see CDC). Diabetic retinopathy is a debilitating condition defined by the loss of vision due to leaky blood vessels of the retina. The current standard of care includes prevention measures, pharmacological therapies,...

Published: 9/27/2024 | Inventor(s): Elias Zambidis, Tea Soon Park

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Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Ophthalmology > Retinal Ischemia

Generation of heart field-specific progenitor cells from pluripotent stem cells

Unmet Need:Heart disease, the number one killer, frequently occurs in a chamber-restricted fashion. While patient-derived pluripotent stem cells (iPSCs) offer unprecedented opportunities to treat and repair damaged hearts, iPSC-derived heart cells are highly heterogeneous, and it remains unknown if chamber-specific heart cells can be induced and isolated....

Published: 9/26/2024 | Inventor(s): Peter Andersen, Chulan Kwon

Keywords(s): Cardiovascular Diseases, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools

Cancer in Angiogenesis

Unmet NeedIn the United States alone, almost 8.5 million people suffer from peripheral artery disease (PAD). The market for PAD and Peripheral Vascular Disease (PVD) is expected to reach $378.53 million with a CAGR of 7.06% by 2024. Therapeutic angiogenesis are therapies aimed at growing new vessels into compromised tissue. Wound healing, PAD, and coronary...

Published: 9/26/2024 | Inventor(s): Andrew Schulick

Keywords(s): Biologics, Cardiovascular Diseases, Cell Model, Coronary Heart Disease, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Peripheral Artery Disease, Stem Cells, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Whole cell, Wound Healing

Category(s): Technology Classifications > Therapeutic Modalities > Stem Cells, Clinical and Disease Specializations > Wound Healing, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Stem Cells

KA.1;KA.3 (human keratinocyte-iPSC)

Technical Details: Described are induced pluripotent stem cells (iPSC) generated from keratinocytes. Keratinocytes were plucked and cultured from human hair and reprogrammed using non-viral, non-integrating methods. The resulting iPSCs contain no evidence of integrated pluripotency transgenes. Associated Publication: PLoS One. 2012;7(8):e42838.

Published: 9/26/2024 | Inventor(s): Elias Zambidis

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Stem Cells

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

HDL2 iPSCs

Invention Novelty: Generation of three lines of induced pluripotent stem cells derived from fibroblast cell lines developed from patients with Huntington's disease-like 2.Value Proposition: HDL2, discovered and genetically defined by the Margolis group, is a rare, autosomal dominant neurodegenerative disorder, clinically and neuropathologically...

Published: 9/26/2024 | Inventor(s): Russell Margolis, Christopher Ross, Dobrila Rudnicki, Hongjun Song, Sergey Akimov

Keywords(s): Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

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