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A natural sg-tracrRNA for S. pyogenes transcriptional repression and cleavage

Unmet Need:CRISPR-Cas9 from Streptococcus pyogenes is the most commonly used due to Cas9’s ability to act as a singular protein and its high gene cutting activity (see Knott and Nakade). Despite the widespread use of CRISPR-Cas9, limitations remain in the efficiency with which precise genome editing occurs (see Banan). CRISPR-Cas9 creates a double-stranded...

Published: 3/13/2026 | Inventor(s): Joshua Modell

Keywords(s): Cloning Reagents, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids

bio-IB3

Unmet NeedAccording to the CDC, approximately 5.8-million individuals aged 65+ in the United States were living with Alzheimer’s disease in 2020 (see CDC). Alzheimer’s disease leads to memory impairment that progressively affects the ability of individuals to conduct daily tasks and worsens with time. Currently, the diagnosis of Alzheimer’s disease...

Published: 3/12/2026 | Inventor(s): Esther Oh, Stina Tucker, David Borchelt, Juan Troncoso

Keywords(s): Alzheimer's Disease, Antibodies, Biologics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Neurodegeneration, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration

Transposon-Based Reporter Vector for High-Efficiency Regulatory DNA Sequence Screening

Value Proposition· Enhanced germline transmission - Tol2 transposon system provides superior integration efficiency compared to episomal DNA and alternative transposon systems· Streamlined cloning workflow - Gateway cloning system enables rapid insertion of test sequences without traditional restriction/ligation steps· Real-time...

Published: 3/12/2026 | Inventor(s): Elizabeth Grice, Shannon Fisher, Andrew McCallion

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

hPSC-derived Oligodendrocyte Reporter Cell System for Screening of Myelination Enhancing Drugs

Unmet NeedA study in 2017 funded by the National MS Society shows that nearly one million people are living with Multiple sclerosis (MS) in the United States. MS is a degenerative disease with no cure. In MS the central nervous system is damaged by the degradation of the protective sheath, called myelin, around the neurons. The cause is unclear, but...

Published: 3/13/2026 | Inventor(s): Donald Zack, Xitiz Chamling

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Target-based Screening Tool

Category(s): Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Technology Classifications > Research Tools > Human Cell Lines

Shikimate Pathway Inhibitors

Unmet NeedAntimicrobial and antibiotic resistance is rising to dangerously high levels throughout the world, posing a critical threat to human health and security. Each year in the United States, at least 2 million people are infected with antibiotic resistant bacteria, which results in at least 23,000 deaths. Thus, there is a great need to identify...

Published: 3/13/2026 | Inventor(s): Joel Bader, Joseph De Angelo, Jef Boeke, Leslie Mitchell

Keywords(s): Discovery/Research Tools, In Vivo Research Tool

Category(s): Technology Classifications > Research Tools > Yeast Model

Low Cost Regulated Genetic Switch for Saccharomyces Cerevisiae

Low Cost Regulated Genetic Switch for Saccharomyces CerevisiaeJHU REF: C12857 Invention Novelty: This technology is a method of using a low cost regulated system for controlling gene expression in the yeast Saccharomyces cerevisiae. Value Proposition:Budding yeast Saccharomyces cerevisiae is one of the most important organisms in biotechnology. Currently...

Published: 3/12/2026 | Inventor(s): Jef Boeke, Shigehito Ikushima

Keywords(s): Cell Signaling, Discovery/Research Tools, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent, Yeast Model

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Yeast Model

Human LRRK2 cDNA

Studies have shown that mutations in the LRRK2 gene are the most common determinants of late-onset Parkinsons disease (PD) susceptibility. These cDNA vectors comprise wild type LRRK2 cDNA or mutated LRRK2 cDNA that can be expressed in cells to decipher the biochemical pathways and pathology of PD. Other advantages include:• Produced from human source...

Published: 3/12/2026 | Inventor(s): Ted Dawson

Keywords(s): Basic Research Biomarker, Cloning Reagents, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Nucleotide, Parkinson's Disease, Research Reagent

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Biomimetic Platforms to Model Vascular Pathophysiology, Diagnostics, and Therapy

Value Proposition· Biomimetic platform of human pulmonary arterioles that enables researchers and clinicians to better understand pulmonary hypertension.· Precisely engineered, tunable, functional, and anatomically accurate biomimetic human pulmonary microvasculature supports quantitative analysis of endothelial and smooth muscle cell...

Published: 3/12/2026 | Inventor(s): Lewis Romer, David Gracias, Jayson Pagaduan, Anil Bhatta, Xing Chen, Qianru Jin

Keywords(s): Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Lung Disorders, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Immortalized Human DRG Neuronal Cell Line

Unmet NeedPeripheral neuropathy is estimated to affect 20 million people in the U.S. alone. Patients suffer from a number of symptoms including: numbness, tingling, pricking sensations, muscle weakness, abnormal sensitivity to touch, and feelings of burning pain. Two of the most common causes of peripheral neuropathy are the result of diabetes and toxicity...

Published: 3/13/2026 | Inventor(s): Ahmet Hoke, Weiran Chen, Gabsang Lee

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Stem Cells

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Stem Cells

Vascular Endothelial Growth Factor and Substrate Mechanics Regulate Vascular Tubulogenesis

Unmet Need:In recent decades, postnatal vasculogenesis has been considered to be an important mechanism for neovascularization via circulating endothelial progenitor cells (EPCs) derived from marrow. Since then, EPCs have been proposed as a potential tool for treating vascular disease, either through infusion to the site of vascularization or ex vivo...

Published: 3/12/2026 | Inventor(s): Donny Hanjaya-Putra, Sharon Gerecht

Keywords(s): Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

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