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INCERTS Methodology for Multiplexing Single Cell Analyses via cDNA Barcoding

A method for integrating cellular phenotype with T cell receptor analysisJHU Ref #: C17820 Value Proposition:· Paired TCR sequencing and phenotypic analysis· High throughput and resolution· Enables pooling of samples Unmet NeedCharacterization of the adaptive immune response has been advanced by single cell RNA-sequencing (scRNA-seq)...

Published: 1/22/2026 | Inventor(s): Harry Larman, Janelle Montagne, Sahana Jayaraman

Keywords(s):

Category(s): Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Incorporation of Lysine Tags as a Universal System for Controlling Protein Expression

Value Proposition· Precise and Tunable Protein Translation Control: Poly(A) track length can be varied from 1-12 AAA codons, providing precise and adjustable control over protein output.· Minimal Complexity: This technology offers predictable, graded control of protein expression using only a short DNA sequence insert—no external inducers,...

Published: 1/22/2026 | Inventor(s): Dorothy Green, Sergej Djuranovic

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Nucleotide, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

A method for inhibiting UHRF1 in colorectal cancer

Value PropositionReversal of colorectal cancer-specific DNA hypermethylationmRNA-based strategy for UHRF1 inhibitionA lipid nanoparticle-based delivery platformUnmet Need1 out of 24 people will develop colorectal cancer. Current technologies do not maximize the bodies’ native ability to suppress tumors. Existing therapies lack specificity and cause...

Published: 1/22/2026 | Inventor(s): Stephen Baylin, Srinivasan Yegnasubramanian, Ying Cui, Xiangqian Kong

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Method for Continuous, Sub-second-resolved, Drift-free and Real-time Interrogation of DNA-based Electrochemical Sensors based on Cyclic Voltammetry

Value Proposition:· Improves temporal stability, reducing batch-to-batch as well as day-to-day variability in sensor performance. · Is drift-free and calibration-free, unlike traditional pulse voltammetry. · Provides additional sensor capacitance information that can report on monolayer stability over time.· Allows for continuous...

Published: 1/22/2026 | Inventor(s): Netzahualcoyotl (Netz) Arroyo-Curras, Miguel Aller Pellitero, Jonathan Mahlum, Samuel Curtis

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays

Short Viral RNAs (svRNAs) with Theragnostic Potential in Infection with SARS-CoV-2 and Related Viruses

Value PropositionNovel Biomarkers for Diagnosis & PrognosisInsights into viral immune evasion mechanism Identify key host pathways targeted by svRNAs Novel Therapeutic TargetsIdentified pathways enable the development of immune-modulating therapies. Unmet NeedStudies have show than SARS-CoV-2 employs various mechanisms to evade the host’s innate...

Published: 1/22/2026 | Inventor(s): Kenneth Witwer, Tom Driedonks, Andrey Turchinovich

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Infectious Diseases

Light-controllable Helicases

Value Proposition· Enhanced accuracy: These enzymes may be used to more accurately sequence DNA · Study control: light activated enzymes may be used for precise manipulation of helicases to be used for in-cell studies.Unmet Need· The enzymatic activity for DNA transcription and translation is frequently used in research and commercial...

Published: 1/22/2026 | Inventor(s): Taekjip Ha, Dmitriy Bobrovnikov, Yann Chemla, Monika Makurath

Keywords(s):

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays

Methods for in situ Detection of DNA Sequence Variation

Value Proposition· High-throughput· Assess genetic variants with simultaneous spatial analysis· Interrogate over 100 variants in a single assayUnmet Need· Next generation sequencing has led to an ever-proliferating dearth of genetic information. More recent progress in nucleoside tissue analysis has birthed the field of spatial...

Published: 1/22/2026 | Inventor(s): Reza Kalhor, Soichiro Asami

Keywords(s):

Category(s): Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids

Composition of Media with Defined Fluid Viscosity for Enhancing Intracellular Delivery of Nanoparticles and Viral Vectors, and Methods of Use

Unmet Need· Production of gene therapies, cell therapies, and recombinant proteins are largely dependent on efficient transfection using viral vectors or nanoparticle vehicles to deliver genetic cargo. However, although numerous transfection reagents have been developed, many strategies still suffer from low efficiency in particular cell-lines...

Published: 1/22/2026 | Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Sean Sun, Zhuoxu Ge, Qin Ni

Keywords(s):

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Viruses, Technology Classifications > Research Tools > Nucleic Acids

Kinetically controlled methods to prepare concentrated shelf-stable nucleic acid transfection vehicles

Value Proposition:· Technology creates particles optimally size for use as vehicles for cell transfection.· The reagents and processes for particle creation are kinetically controlled and reproducible.· Cationic particles created using these methods can carry larger payloads than current vehicles.· Reagents and nucleic acid-loaded...

Published: 1/22/2026 | Inventor(s): Hai-Quan Mao, Yizong Hu, Jinghan Lin

Keywords(s):

Organo-phosphate Modified Metal Organic Frameworks and Applications

Marketing Summary Draft #C17480 Organo-phosphate Modified Metal Organic Frameworks and ApplicationsInventors: Michael Tsapatsis, Efrosini Kokkoli, Danyu WangUnmet NeedThere is a continuously growing need for new and better asymmetric catalysts, as is evidenced by the fact that the 2021 Nobel Prize in Chemistry went to two scientists for development...

Published: 1/22/2026 | Inventor(s): Michael Tsapatsis, Efrosini Kokkoli, Danyu Wang

Keywords(s):

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

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