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A natural sg-tracrRNA for S. pyogenes transcriptional repression and cleavage

Unmet Need:CRISPR-Cas9 from Streptococcus pyogenes is the most commonly used due to Cas9’s ability to act as a singular protein and its high gene cutting activity (see Knott and Nakade). Despite the widespread use of CRISPR-Cas9, limitations remain in the efficiency with which precise genome editing occurs (see Banan). CRISPR-Cas9 creates a double-stranded...

Published: 3/13/2026 | Inventor(s): Joshua Modell

Keywords(s): Cloning Reagents, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids

Bicistronic Genes and Fusion Proteins for Immune Activation

Value Proposition:· Dual specific targeting for improved full T-cell and amplification.· Interchangeable protein components can be customized for cancer, infectious disease, and autoimmune disorder therapies.· Deliverable by nanoparticles into cells in vivo, in vitro, and ex vivo for immune activation.Unmet Need:Immunotherapy is a rapidly...

Published: 3/13/2026 | Inventor(s): Jordan Green, Joanna Yang, Stephany Tzeng, Jamie Spangler

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Nucleic Acids

Methods for High-throughput Identification of Genomic Harbors for Transgene Expression in Cells

Value Proposition:· High-throughput screening of loci for exogenous gene insertion · Quantifies expression level of exogenous genes in cell type of interest Unmet Need· Exogenous or synthetic genes that are inserted into the genome serve various purposes, depending on the context and goals of the genetic modification. This includes...

Published: 3/13/2026 | Inventor(s): Reza Kalhor, Jinwoo Jun, Kathleen Leeper

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Gene Therapies

Multi-temperature Fluorometric Measurement for Multiplex Analyte Detection with Digital PCR Systems

Multiplex digital PCR diagnostic systemJHU Ref #: C18050Value Proposition:· The use of color-specific and temperature-specific probes allows for unique molecular signals during digital PCR reaction· Can detect low abundance disease biomarkers in a variety of disease settings· Enhanced throughput and sensitivity compared to current...

Published: 3/13/2026 | Inventor(s): Tza-Huei Wang, Fan-En Chen, Yang Zhao, Weiwen Cui, Jiumei Hu

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics > In Vitro Diagnostics

Method to Use a DNA Oligonucleotide to Bind and Unbind Functional DNA Origami Structures for Applications in Biological Sensing, Transport and Self-assembly

Unmet NeedMolecular assemblies inside cells often undergo structural reconfiguration in response to stimuli to alter their function. Adaptive reconfiguration of cytoskeletal networks, for example, enables cellular shape change, movement, and cargo transport and plays a key role in driving complex processes such as division and differentiation. The cellular...

Published: 3/13/2026 | Inventor(s): Rebecca Schulman, Samuel Schaffter, Joanna Schneider, Yi Li, Daniel Siegal

Keywords(s):

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays, Technology Classifications > Therapeutic Modalities > Targets

Human LRRK2 cDNA

Studies have shown that mutations in the LRRK2 gene are the most common determinants of late-onset Parkinsons disease (PD) susceptibility. These cDNA vectors comprise wild type LRRK2 cDNA or mutated LRRK2 cDNA that can be expressed in cells to decipher the biochemical pathways and pathology of PD. Other advantages include:• Produced from human source...

Published: 3/12/2026 | Inventor(s): Ted Dawson

Keywords(s): Basic Research Biomarker, Cloning Reagents, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Nucleotide, Parkinson's Disease, Research Reagent

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Spatial Analysis of RNA Using Probe Ligation and Amplification in situ

Unmet NeedTraditional gene expression methods that use bulk RNA analysis lack the ability to resolve transcript location, and thus fail to capture the inherent cellular heterogeneity present in virtually every tissue. Abundance and localization of RNA transcripts mapped to specific regions of tissue can complement histological analysis, providing an...

Published: 3/13/2026 | Inventor(s): Harry Larman, Joel Credle

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

INCERTS Methodology for Multiplexing Single Cell Analyses via cDNA Barcoding

A method for integrating cellular phenotype with T cell receptor analysisJHU Ref #: C17820 Value Proposition:· Paired TCR sequencing and phenotypic analysis· High throughput and resolution· Enables pooling of samples Unmet NeedCharacterization of the adaptive immune response has been advanced by single cell RNA-sequencing (scRNA-seq)...

Published: 3/13/2026 | Inventor(s): Harry Larman, Janelle Montagne, Sahana Jayaraman

Keywords(s):

Category(s): Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Incorporation of Lysine Tags as a Universal System for Controlling Protein Expression

Value Proposition· Precise and Tunable Protein Translation Control: Poly(A) track length can be varied from 1-12 AAA codons, providing precise and adjustable control over protein output.· Minimal Complexity: This technology offers predictable, graded control of protein expression using only a short DNA sequence insert—no external inducers,...

Published: 3/12/2026 | Inventor(s): Dorothy Green, Sergej Djuranovic

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Nucleotide, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

A method for inhibiting UHRF1 in colorectal cancer

Value PropositionReversal of colorectal cancer-specific DNA hypermethylationmRNA-based strategy for UHRF1 inhibitionA lipid nanoparticle-based delivery platformUnmet Need1 out of 24 people will develop colorectal cancer. Current technologies do not maximize the bodies’ native ability to suppress tumors. Existing therapies lack specificity and cause...

Published: 3/13/2026 | Inventor(s): Stephen Baylin, Srinivasan Yegnasubramanian, Ying Cui, Xiangqian Kong

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

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