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Methods for in situ Detection of DNA Sequence Variation
Value Proposition·        High-throughput·        Assess genetic variants with simultaneous spatial analysis·        Interrogate over 100 variants in a single assayUnmet Need·        Next generation sequencing has led to an ever-proliferating dearth of genetic information. More recent progress in nucleoside tissue analysis has birthed the field of spatial...
Published: 3/14/2025   |   Inventor(s): Reza Kalhor, Soichiro Asami
Keywords(s):  
Category(s): Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids
Composition of Media with Defined Fluid Viscosity for Enhancing Intracellular Delivery of Nanoparticles and Viral Vectors, and Methods of Use
Unmet Need·        Production of gene therapies, cell therapies, and recombinant proteins are largely dependent on efficient transfection using viral vectors or nanoparticle vehicles to deliver genetic cargo. However, although numerous transfection reagents have been developed, many strategies still suffer from low efficiency in particular cell-lines...
Published: 3/14/2025   |   Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Sean Sun, Zhuoxu Ge, Qin Ni
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Viruses, Technology Classifications > Research Tools > Nucleic Acids
Kinetically controlled methods to prepare concentrated shelf-stable nucleic acid transfection vehicles
Value Proposition:·        Technology creates particles optimally size for use as vehicles for cell transfection.·        The reagents and processes for particle creation are kinetically controlled and reproducible.·        Cationic particles created using these methods can carry larger payloads than current vehicles.·        Reagents and nucleic acid-loaded...
Published: 3/14/2025   |   Inventor(s): Hai-Quan Mao, Yizong Hu, Jinghan Lin
Keywords(s):  
Category(s): Technology Classifications > Engineering Tech > Bioreactors, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Industrial Tech > Bioreactors, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Peptides, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms
Targeted capture of custom nucleotide sequences for single-cell sequencing
Value Proposition·      Implementation only requires simple modification of current capture beads.·      Allows for targeting of custom sequences of interest that may be cell-type specific or expressed at low levels.·      Targets RNA molecules without polyA tails.·      Inexpensive modification to existing commercial methods. Technology DescriptionResearchers...
Published: 3/14/2025   |   Inventor(s): Jonathan Ling, Katherine Irwin, Irika Sinha, Philip Wong, Linda Orzolek, Tyler Creamer
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Assays
CRISPR/Cas9 and Tumor-Specific Guide RNAs as a Specific and Selective Cancer Cell Killing Biologic Platform
Value Proposition:Specific targeting of mutations can treat any cancer with the specified mutations.Selective cell killing spares healthy tissue while eliminating cancer cells. Pan-cancer efficacy as guide RNAs are developed to target a wide breadth of cancer-specific mutations.Lack of protospacer adjacent motif (PAM) sites in healthy host cells prevents...
Published: 3/14/2025   |   Inventor(s): James Eshleman, Selina Shiqing Teh, Kirsten Bowland, Nicholas Roberts
Keywords(s):  
Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Pancreatic Ductal Adenocarcinoma, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Research Tools > Nucleic Acids
Compositions of Kinetic Nanoparticles containing Nucleic Acids, Polycations, and Lipids with Defined Sizes, and Methods of Producing the Same
Value Proposition:·        Scalable, efficient, and tunable nanoparticle creation technique that can deliver a variety of payloads·        Polymer-lipid nanoparticles are biodegradable and are being tested for immunogenicity·        Can be used for in vivo gene therapy delivery as well as in vitro cell transfection and research applications Technology...
Published: 3/14/2025   |   Inventor(s): Hai-Quan Mao, Stephany Tzeng, Jordan Green, Yizong Hu, Sashank Reddy, Leonardo Cheng
Keywords(s):  
Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Peptides, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms
Identification of RNF43 Mutations in Pancreatic Cysts
Unmet Need·        One third of diagnoses for surgical resection of pancreatic cysts are incorrect, leading to unnecessary surgery, medical risk, and high costs (Hammel, 2002). The current standard of care for determining pancreatic cyst type is based solely on symptom progression and imaging criteria, and histopathological analysis is only available...
Published: 3/13/2025   |   Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Jian Wu, Anirban Maitra, Ralph Hruban, Marco Dal Molin
Keywords(s): Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, Nucleotide, Pancreatic Cancer, Research Reagent, Translational Research Biomarker
Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers
Repetitive Element Aneuploidy Sequencing Systems (REAL-SeqS)
Unmet NeedAneuploidies are chromosomal alterations that are present in the majority of cancers and associated with numerous genetic disorders. Consequently, the detection of aneuploidy in clinical samples has important applications in prenatal testing and cancer diagnostics. The current, noninvasive methods for detecting aneuploidy in clinical samples...
Published: 3/14/2025   |   Inventor(s): Bert Vogelstein, Kenneth Kinzler, Christopher Douville, Nickolas Papadopoulos, Cristian Tomasetti
Keywords(s): Analytical Method, Discovery/Research Tools, In Vitro Research Tool
Category(s): Technology Classifications > Research Tools > Nucleic Acids
Methods for Payload and Size Characterization of Nucleic Acid Nanoparticles
Polymeric and lipid nanoparticles (NPs) are an effective and safe method for therapeutic delivery. At each of the various steps in nanoparticle development and manufacturing (i.e., research and design, quality assurance), assessing the features of these vehicles is essential. Some features (i.e., packaging characteristics, cargo location, structure...
Published: 3/14/2025   |   Inventor(s): Tza-Huei Wang, Hai-Quan Mao, Sixuan Li, Yizong Hu, Andrew Li
Keywords(s):  
Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids
Solid-phase Synthesis of Oligonucleotides Containing N6-(2-Deoxy-alpha,beta-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy•dG)
Unmet Need: Study of the common DNA damage oxidative lesion Fapy∙dG has been extremely limited due to the lack of tools available to synthesize oligonucleotides containing this lesion.   Technical Details: Johns Hopkins researchers have developed a solid-phase synthetic method to prepare oligonucleotides containing N6-(2-Deoxy-α,β-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine...
Published: 3/14/2025   |   Inventor(s): Marc Greenberg, Haozhe Yang
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Nucleic Acids
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