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Olfactory Receptor Trafficking in Mammalian Cells

Invention novelty: The invention is a method and composition to ensure the cell surface expression of olfactory receptors (ORs) in heterologous systems.Value Proposition: Olfactory receptors are difficult to express in cell systems from which they are not derived. The ORs tend to remain intracellular in such systems, and use of these systems to identify...

Published: 3/13/2025 | Inventor(s): Jennifer Pluznick, Blythe Shepard, Niranjana Natarajan

Keywords(s): Discovery/Research Tools, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Antibodies to Visual Pigment Proteins, Transcription Factor Sox17, and Multimerized Epitope Tags

Unmet Need:Canonical Wnt signaling is one of the major pathways involved in embryonic development and tissue regeneration. Recent studies suggest that canonical Wnt signaling is vital for brain angiogenesis and the acquisition of barrier properties by the microvasculature. There is a need in the field for the development of reagents that allow for the...

Published: 3/14/2025 | Inventor(s): Jeremy Nathans

Keywords(s): Antibodies, Discovery/Research Tools, Labels/Markers, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Research Antibodies

Ratiometric Fluorescence Coding Method for Multiplex Nucleic Acid Amplification Assays

Unmet NeedNucleic acid amplification testing (NAAT) is a powerful analytic method that involves the amplification of genetic material, DNA or RNA, for the detection and identification of infectious microbial and viral pathogens like HIV, hepatitis B and C, as well as, oncogene mutations and genetic disorders. One example of its global importance is...

Published: 3/14/2025 | Inventor(s): Tza-Huei Wang, Ye Zhang

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Know-how, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays

New fluorinated DREADD actuators and ligands suitable for PET imaging

Unmet NeedChemogenetics is defined as a method by which proteins are made to interact with small molecules, typically neurological molecules, as they have never been interacted with before. There is a powerful and versatile approach for remote and momentary manipulation of cellular activity called Designer Receptors Exclusively Activated by Designer...

Published: 3/14/2025 | Inventor(s): Andrew Horti, Martin Pomper, Michael Michaelides, Jordi Bonaventura, Feng Hu, Juan Luis Gomez, Marta Sanchez-Soto

Keywords(s): Biologics, Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Labels/Markers, Radioisotope Therapy, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Enzymatic labeling of poly(ADP-ribose) polymer and ADP-ribosylated proteins

Unmet NeedDysregulation of ADP-ribosylation, the process of adding ADP-ribose groups onto proteins, has been implicated in the pathogenesis of cancer, viral infection, and neurodegeneration. To date, three drugs that inhibit polyADP-ribose polymerases (PARP) have been approved by the FDA to treat ovarian and other cancers. Though a promising new therapeutic...

Published: 3/13/2025 | Inventor(s): Anthony Leung, Yoshinari Ando, Robert McPherson, Elad Elkayam, Mohsen Badiee

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Anastasis Biosensor CaspaseTracker rtTA

Anastasis Biosensor CaspaseTracker rtTA – C15014 Unmet NeedAnastasis, Greek for "rising to life", is a newly discovered cell recovery phenomenon by which a cell undergoes reversal of apoptosis or programmed cell death. Research has shown that even cells that exhibit the hallmarks of late-stage cell death such as activation of executioner caspases...

Published: 3/13/2025 | Inventor(s): Ho Lam Tang, Ho Man Holly Tang

Keywords(s): Animal Imaging Tools, apoptosis, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vitro Diagnostics, In Vivo Medical Imaging, In Vivo Research Tool, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers

The CS Tag: A More Sensitive and Specific Protein Tag

Protein tags are short linear sequences that are added onto proteins in order to facilitate their detection. The most commonly used tags are FLAG, Myc, HA and His ). Tagging proteins has two primary uses. The first is for protein expression in heterologous systemsand the second use is in localization studies. . We and others have found that antibodies...

Published: 3/13/2025 | Inventor(s): Photini Sinnis, Fidel Zavala

Keywords(s): Discovery/Research Tools, Labels/Markers, Proteomics/Immunoassays, Research Reagent

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics

Radiolabeled Triazole Conjugated Ureas (YC-88)

Prostate-specific membrane antigen (PSMA) is a type II integral membrane protein expressed on the surface of prostate tumors, particularly in castrate-resistant, advanced and metastatic disease. PSMA is also expressed in neovascular endothelium of most solid tumors, such as lung, colon, pancreatic, renal carcinoma and skin melanoma, but not in normal...

Published: 3/13/2025 | Inventor(s): Martin Pomper, Ronnie Mease, Ying Chen, Sangeeta Ray, Xing Yang

Keywords(s): Antagonists/Inhibitors, Cancers, Discovery/Research Tools, Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Labels/Markers, Novel, Predicted Novelty, Research Reagent, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics > Diagnostic Imaging

C11872: Novel Method to Visualize Cells that Undergo Apoptosis Reversal

Value Proposition: This biosensor may be used to identify anastasis events in animals or cells, in screens to identify genes/protein/RNAs that modulate anastasis or in screens for small molecules that potentiate or inhibit anastasis. Technology advantages: - This biosensor can be used to label cells in vivo or in vitro. - This technology permanently...

Published: 3/13/2025 | Inventor(s): Ho Lam Tang, Denise Montell

Keywords(s): Discovery/Research Tools, Fly Model, Imaging and Sensing Systems, In Vitro Research Tool, In Vivo Medical Imaging, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Technology Classifications > Research Tools

A Method to Increase Availability of Specific Membrane Lipids (termed "lipid liberation")

C11757: Cell Membrane Lipid “Liberation” for Research UseNovelty: This invention is a method of manipulating the availability of lipids in the plasma membrane on a timescale of seconds.Value Proposition: Currently, there is no technique to effectively change the lipid availability (lipid liberation) in the plasma membrane on a timescale of seconds....

Published: 3/13/2025 | Inventor(s): Tasuku Ueno, Bjorn Falkenburger, Takanari Inoue

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Labels/Markers, Research Instrument, Research Reagent

Category(s): Technology Classifications > Research Tools

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