Search Results - molecular+switches%2freceptors

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C03338: 14-3-3 Mediates a p53-Induced G2 Arrest Technical Details: Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/SDI1, but the basis for the G2 arrest is unknown. Through a quantitative...

Published: 9/26/2024 | Inventor(s): Heiko Hermeking, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Cell Lines, Cell Signaling, Discovery/Research Tools, Disease Indication, Gene Therapy, Human Cell Lines, In Vitro Research Tool, Molecular Switches/Receptors, Pharmakodynamic Biomarker, Research Reagent, Single, Therapeutic Matter, Therapeutics, Therapy Type, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

Molecular Switches and Methods for Making and Using the Same Involving the Circular Permutation of DNA

Technical Details: The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide...

Published: 9/26/2024 | Inventor(s): Gurkan Guntas, Marc Ostermeier

Keywords(s): Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Gene Therapy, Molecular Switches/Receptors, Research Reagent, Single, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Therapy Type

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Gene Therapies

Ankyrin-G and Ion Channel Pathway Cell Model for Testing Psychiatric Therapeutics

TITLE Ankyrin-G and Ion Channel Pathway Cell Model for Testing Psychiatric TherapeuticsCASE NUMBERC13171ABSTRACTL-Type calcium channel loci and the Ankyrin-G locus have emerged from Genome-Wide Association Studies as among the major risk factors for human psychiatric disorders, and Johns Hopkins researchers...

Published: 9/26/2024 | Inventor(s): Shanshan Zhu, Christopher Ross

Keywords(s): Cell Signaling, Discovery/Research Tools, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent, Target-based Screening Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays

NKCC1-pcDNA3-GFP

Invention novelty: This tangible material is a plasmid vector expressing a NKCC1-EGFP fusion protein. Value Proposition: NKCC1 (Na+-K+-Cl- cotransporter 1) regulates cell volume and accumulation of intracellular Cl- and has been shown to promote invasiveness of brain tumor cells by modulating cell adhesion and cell migration. This vector is a tool that...

Published: 9/26/2024 | Inventor(s): Tomas Garzon-Muvdi, Colette Aprhys, Alfredo Quinones-Hinojosa

Keywords(s): Basic Research Biomarker, Brain Cancer, Cancers, Cell Signaling, Cloning Reagents, Discovery/Research Tools, Disease Indication, Glioblastoma, Glioma, Molecular Switches/Receptors, Plasmid, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Brain Cancer

293 ShhN

C12239: Novel Cell Line Used in Hh ligand ProductionNovelty: This tangible material is a 293 ShhN cell line for production of soluble, active Sonic Hh (Shh) ligand.Value Proposition: The most well-known Hh pathway ligand, Sonic Hh (Shh), has been shown to participate in development of the central nervous system. This technology, by enabling production...

Published: 9/26/2024 | Inventor(s): Philip Beachy

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Signaling, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

Artificial Cells of Defined and Dynamic Size and Shape

Invention novelty: This invention is polymer based artificial cells that can be functionalized to induce an immune response or act as stem cells. Value PropositionAntibiotics are the most commonly used treatment for infectious diseases. Unfortunately, overuse and misuse of these compounds is fairly common, and results in the development of antibiotic...

Published: 9/26/2024 | Inventor(s): Joel Sunshine, Karlo Perica, Jonathan Schneck, Jordan Green

Keywords(s): Cancers, Cell Signaling, Cell Therapy, Discovery/Research Tools, Disease Indication, Melanoma, Molecular Switches/Receptors, Research Reagent, Single, Skin Cancer, Therapeutic Matter, Therapeutics, Therapy Type, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Melanoma

Chemically Inducible Dimerization System Using Gibberellin Analogs and their Binding Proteins

C11777: Chemically Inducible Dimerization System for Studying Signal TransductionNovelty: The technology presents a novel research tool for manipulation of signal transduction using dimerization through modified gibberellins.Value Proposition: The technology is a novel system involving use of gibberellins analogs to manipulate and visualize protein...

Published: 9/26/2024 | Inventor(s): David Meyers, Takafumi Miyamoto, Robert Derose, Takanari Inoue

Keywords(s): Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Molecular Switches/Receptors, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Small Peptide Stimulator of NHE3, the Brush Border Epithelial Na/H Exchanger

C11498: Effective Treatment of Acute Diarrhea Using a Novel Peptide Modification Novelty: A peptide derived from the Sodium-Hydrogen Exchanger-3 (NHE-3) protein that increases sodium absorption in the intestine, aiding rehydration and can be used as a therapeutic for acute diarrhea. Value Proposition: The Center for Disease Control recommends...

Published: 9/26/2024 | Inventor(s): Randen Patterson, Damian Van Rossum, Nicholas Zachos, Mark Donowitz

Keywords(s): Acute Diarrhea, Basic Research Biomarker, Biologics, Cell Signaling, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Molecular Switches/Receptors, Peptide, Peptides, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Gastroenterology

Method for Incorporating Internal Polar and Ionizable Groups in Proteins

NOVELTY: This technology comprises a novel method to introduce polar and ionizable groups into the interior of proteins without the loss of protein stability.VALUE PROPOSITION: Currently, the loss of stability related to the introduction of internal ionizable groups has plagued efforts in protein engineering. The disclosed technology overcomes the current...

Published: 9/26/2024 | Inventor(s): Daniel Isom, Bertrand Garcia-Moreno

Keywords(s): Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Molecular Switches/Receptors, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Modulation of ABCG2-mediated Urate Transport to Treat Hyperuricemia and Gout

C10666: Treatment of Hyperuricemia and Gout Technical Details: About 3 million people in U.S. are suffering from insufficiently treated gout. Incidence has more than tripled in the past 20 years, as the disease is correlated with being overweight, drinking too much alcohol, or having diets too high in meat or fish. It is well established that gout...

Published: 9/26/2024 | Inventor(s): Owen Woodward, William Guggino, Josef Coresh, Anna Kottgen, Michael Kottgen

Keywords(s): Biomarker, Cell Signaling, Discovery/Research Tools, Disease Indication, Gout, Inflammatory Disorders, Mechanism-of-action Biomarker, Molecular Switches/Receptors, Research Reagent, Therapeutic Matter, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation > Gout, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Inflammation, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Targets

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